Search Results - "GROUNDS, M. D"

Two-tiered hypotheses for Duchenne muscular dystrophy by Grounds, M. D

“…New approaches to understanding and designing treatments for Duchenne muscular dystrophy (DMD) may emerge from two hypotheses outlined here. The proposal that…”
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Macrophage function in the elderly and impact on injury repair and cancer by Duong, L, Radley, H G, Lee, B, Dye, D E, Pixley, F J, Grounds, M D, Nelson, D J, Jackaman, C

“…Older age is associated with deteriorating health, including escalating risk of diseases such as cancer, and a diminished ability to repair following injury…”
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Effects of loaded voluntary wheel exercise on performance and muscle hypertrophy in young and old male C57Bl/6J mice by Soffe, Z., Radley-Crabb, H. G., McMahon, C., Grounds, M. D., Shavlakadze, T.

“…This study compared the capacity of young and old male C57Bl/6J mice to exercise with increasing resistance over 10 weeks, and its impact on muscle mass. Young…”
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Strength at the extracellular matrix-muscle interface by Grounds, M. D., Sorokin, L., White, J.

“…Mechanical force is generated within skeletal muscle cells by contraction of specialized myofibrillar proteins. This paper explores how the contractile force…”
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Impact of fasting on the rhythmic expression of myogenic and metabolic factors in skeletal muscle of adult mice by Shavlakadze, T, Anwari, T, Soffe, Z, Cozens, G, Mark, P J, Gondro, C, Grounds, M D

“…Circadian rhythms and metabolism are tightly integrated, and rhythmic expression of metabolic factors is common in homeostatic processes. We measured the…”
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What is the mechanism for in vivo loss of skeletal muscle function in elderly women? by Grounds, M. D., Pinniger, G. J.

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Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in mice by McMahon, C. D., Chai, R., Radley-Crabb, H. G., Watson, T., Matthews, K. G., Sheard, P. W., Soffe, Z., Grounds, M. D., Shavlakadze, T.

“…The age‐related loss of skeletal muscle mass and function is termed sarcopenia and has been attributed to a decline in concentrations of insulin‐like growth…”
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Evans Blue Dye as an in vivo marker of myofibre damage: optimising parameters for detecting initial myofibre membrane permeability by Hamer, P. W., McGeachie, J. M., Davies, M. J., Grounds, M. D.

“…Evans Blue Dye (EBD) is widely used to study cellular membrane permeability and has recently been utilised in mdx mice to identify permeable skeletal myofibres…”
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The Role of Tumor Necrosis Factor-alpha (TNF-α) in Skeletal Muscle Regeneration: Studies in TNF-α(-/-) and TNF-α(-/-)/LT-α(-/-) Mice by Collins, Rachel A., Grounds, Miranda D.

“…The role of tumor necrosis factor-alpha (TNF-α), an important mediator of the inflammatory response after injury, was investigated in regenerating skeletal…”
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New horizons in the pathogenesis, diagnosis and management of sarcopenia by Sayer, Avan Aihie, Robinson, Sian M, Patel, Harnish P, Shavlakadze, Tea, Cooper, Cyrus, Grounds, Miranda D

“…Sarcopenia is the age-related loss of skeletal muscle mass and function. It is now recognised as a major clinical problem for older people and research in the…”
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Blockade of TNF in vivo using cV1q antibody reduces contractile dysfunction of skeletal muscle in response to eccentric exercise in dystrophic mdx and normal mice by Piers, A.T, Lavin, T, Radley-Crabb, H.G, Bakker, A.J, Grounds, M.D, Pinniger, G.J

“…Abstract This study evaluated the contribution of the pro-inflammatory cytokine, tumour necrosis factor (TNF) to the severity of exercise-induced muscle damage…”
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The role of macrophages in skeletal muscle regeneration with particular reference to chemotaxis by Robertson, T A, Maley, M A, Grounds, M D, Papadimitriou, J M

“…The results from this investigation suggest that chemotactic factor(s) from damaged myofibers attract polymorphonuclear leukocytes (PML) and macrophages to the…”
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Why do cultured transplanted myoblasts die in vivo? DNA quantification shows enhanced survival of donor male myoblasts in host mice depleted of CD4+ and CD8+ cells or Nk1.1+ cells by Hodgetts, S I, Beilharz, M W, Scalzo, A A, Grounds, M D

“…Overcoming the massive and rapid death of injected donor myoblasts is the primary hurdle for successful myoblast transfer therapy (MTT), designed as a…”
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Myotube Formation is Delayed but not Prevented in MyoD-deficient Skeletal Muscle: Studies in Regenerating Whole Muscle Grafts of Adult Mice by White, Jason D, Scaffidi, Amelia, Davies, Marilyn, McGeachie, John, Rudnicki, Michael A, Grounds, Miranda D

“…We compared the time course of myogenic events in vivo in regenerating whole muscle grafts in MyoD(−/−) and control BALB/c adult mice using…”
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Macrophages and dendritic cells in normal and regenerating murine skeletal muscle by Pimorady-Esfahani, Arjang, Grounds, Miranda D., McMenamin, Paul G.

“…Mononuclear phagocytes and MHC class II+ dendritic cells (DC) were identified in frozen sections of skeletal muscle using a panel of pan‐specific…”
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Duchenne muscular dystrophy: Focus on pharmaceutical and nutritional interventions by Radley, H.G., De Luca, A., Lynch, G.S., Grounds, M.D.

“…Duchenne muscular dystrophy is a lethal X-linked muscle disease resulting from a defect in the muscle membrane protein dystrophin. The absence of dystrophin…”
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A novel role for non-muscle γ-actin in skeletal muscle sarcomere assembly by Lloyd, C.M, Berendse, M, Lloyd, D.G, Schevzov, G, Grounds, M.D

“…Existing models describing sarcomere assembly have arisen primarily from studies using cardiac muscle. In contrast to cardiac muscle, skeletal muscle…”
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Towards understanding skeletal muscle regeneration by Grounds, M D

“…Factors which effect proliferation and fusion of muscle precursor cells have been studied extensively in tissue culture, although little is known about these…”
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Exposure to tissue culture conditions can adversely affect myoblast behavior in vivo in whole muscle grafts: implications for myoblast transfer therapy by Smythe, G M, Grounds, M D

“…The effects of tissue culture conditions on the viability of myoblasts in whole muscles transplanted in vivo were investigated. Whole male (SJL/J) donor…”
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Absence of desmin slightly prolongs myoblast proliferation and delays fusion in vivo in regenerating grafts of skeletal muscle by Smythe, G M, Davies, M J, Paulin, D, Grounds, M D

“…The expression of desmin, a muscle-specific intermediate filament protein, is upregulated during skeletal myogenesis, but its role in the myogenic process is…”
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