Search Results - "GROSSNIKLAUS, HANS E."

Vimentin Is Required for Lung Adenocarcinoma Metastasis via Heterotypic Tumor Cell-Cancer-Associated Fibroblast Interactions during Collective Invasion by Richardson, Alessandra M, Havel, Lauren S, Koyen, Allyson E, Konen, Jessica M, Shupe, John, Wiles, 4th, W G, Martin, W David, Grossniklaus, Hans E, Sica, Gabriel, Gilbert-Ross, Melissa, Marcus, Adam I

“…Vimentin is an epithelial-to-mesenchymal transition (EMT) biomarker and intermediate filament protein that functions during cell migration to maintain…”
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Animal models of choroidal and retinal neovascularization by Grossniklaus, Hans E., Kang, Shin J., Berglin, Lennart

“…There have been numerous types of animal models of choroidal neovascularization (CNV) and retinal neovascularization (RNV). Understanding the pathobiology of…”
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Age-related retinopathy in NRF2-deficient mice by Zhao, Zhenyang, Chen, Yan, Wang, Jian, Sternberg, Paul, Freeman, Michael L, Grossniklaus, Hans E, Cai, Jiyang

“…Cumulative oxidative damage is implicated in the pathogenesis of age-related macular degeneration (AMD). Nuclear factor erythroid 2-related factor 2 (NRF2) is…”
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Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma by Dong, Lei, You, Shuo, Zhang, Qing, Osuka, Satoru, Devi, Narra S, Kaluz, Stefan, Ferguson, Jalisa H, Yang, Hua, Chen, Guoliang, Wang, Binghe, Grossniklaus, Hans E, Van Meir, Erwin G

“…Uveal melanoma (UM) is the most prevalent and lethal intraocular malignancy in adults. Here, we examined the importance of hypoxia in UM growth and tested the…”
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Estimation of the timing of BAP1 mutation in uveal melanoma progression by Uner, Ogul E., See, Thonnie Rose O., Szalai, Eszter, Grossniklaus, Hans E., Stålhammar, Gustav

“…Uveal melanoma is the most common primary intraocular malignancy. A vast majority of metastasizing tumors have mutations in the BAP1 gene. Here, we investigate…”
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Orbital Lymphoma—An International Multicenter Retrospective Study by Olsen, Tine Gadegaard, Holm, Frederik, Mikkelsen, Lauge Hjorth, Rasmussen, Peter Kristian, Coupland, Sarah E., Esmaeli, Bita, Finger, Paul T., Graue, Gerardo F., Grossniklaus, Hans E., Honavar, Santosh G., Khong, Jwu Jin, McKelvie, Penelope A., Mulay, Kaustubh, Sjö, Lene Dissing, Vemuganti, Geeta K., Thuro, Bradley A., Heegaard, Steffen

“…To investigate and characterize the clinical features of subtype-specific orbital lymphoma. Retrospective, interventional case series. The study included 7…”
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Spontaneous Corneal Clearing after Descemet's Stripping without Endothelial Replacement by Shah, Rupa D., MD, Randleman, J. Bradley, MD, Grossniklaus, Hans E., MD, MBA

“…Purpose To report spontaneous corneal clearing with improved visual acuity and central endothelial cell repopulation after Descemet's stripping without…”
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Expression of immune checkpoint receptors Indoleamine 2,3‐dioxygenase and T cell Ig and ITIM domain in metastatic versus nonmetastatic choroidal melanoma by Stålhammar, Gustav, Seregard, Stefan, Grossniklaus, Hans E.

“…Background Survival in metastasized cutaneous melanoma (CM) has been improved with the advent of inhibitors of immune checkpoints CTLA4 and PD‐1. In contrast,…”
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Ophthalmic Pathology: History, Accomplishments, Challenges, and Goals by Grossniklaus, Hans E., MD

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Evaluation for High-risk HPV in Squamous Cell Carcinomas and Precursor Lesions Arising in the Conjunctiva and Lacrimal Sac by Afrogheh, Amir H, Jakobiec, Frederick A, Hammon, Rebecca, Grossniklaus, Hans E, Rocco, James, Lindeman, Neal I, Sadow, Peter M, Faquin, William C

“…High-risk human papilloma virus (HR-HPV) is a well-established causative agent of oropharyngeal squamous cell carcinoma (SCC). In addition, HR-HPV has…”
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Analysis of Varicella-Zoster Virus in Temporal Arteries Biopsy Positive and Negative for Giant Cell Arteritis by Nagel, Maria A, White, Teresa, Khmeleva, Nelly, Rempel, April, Boyer, Philip J, Bennett, Jeffrey L, Haller, Andrea, Lear-Kaul, Kelly, Kandasmy, Balasurbramaniyam, Amato, Malena, Wood, Edward, Durairaj, Vikram, Fogt, Franz, Tamhankar, Madhura A, Grossniklaus, Hans E, Poppiti, Robert J, Bockelman, Brian, Keyvani, Kathy, Pollak, Lea, Mendlovic, Sonia, Fowkes, Mary, Eberhart, Charles G, Buttmann, Mathias, Toyka, Klaus V, Meyer-ter-Vehn, Tobias, Petursdottir, Vigdis, Gilden, Don

“…Giant cell arteritis (GCA) is the most common systemic vasculitis in elderly individuals. Diagnosis is confirmed by temporal artery (TA) biopsy, although…”
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Anatomic alterations in aging and age-related diseases of the eye by Grossniklaus, Hans E, Nickerson, John M, Edelhauser, Henry F, Bergman, Louise A M K, Berglin, Lennart

“…We described anatomic age-related changes in the human eye to determine potential areas of investigation that may lead to identifying eyes at risk for…”
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Natural killer cells and pigment epithelial-derived factor control the infiltrative and nodular growth of hepatic metastases in an Orthotopic murine model of ocular melanoma by Jones, Nyasia M, Yang, Hua, Zhang, Qing, Morales-Tirado, Vanessa M, Grossniklaus, Hans E

“…Metastases account for 90% of all cancer-related deaths, becoming a therapeutic problem. Approximately 50% of all uveal melanoma (UM) patients will develop…”
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Metastatic Ocular Melanoma to the Liver Exhibits Infiltrative and Nodular Growth Patterns by Grossniklaus, Hans E., MD, Zhang, Qing, MD, PhD, You, Shuo, MD, PhD, McCarthy, Conni, DrSc, MSc, BSc, Heegaard, Steffen, MD, DMSc, Coupland, Sarah E., MBBS, PhD

“…We examined liver specimens from 15 patients with uveal melanoma (UM) who had succumbed to their disseminated disease. We found two distinct growth patterns of…”
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Langerhans Cell Histiocytosis of the Orbit: Five Clinicopathologic Cases and Review of the Literature by Herwig, Martina C., MD, Wojno, Ted, MD, Zhang, Qing, MD, Grossniklaus, Hans E., MD, MBA

“…Abstract Langerhans cell histiocytosis (LCH) is a proliferation of Langerhans cells intermixed with inflammatory cells, in particular eosinophils, that may…”
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Protein MRI contrast agent with unprecedented metal selectivity and sensitivity for liver cancer imaging by Xue, Shenghui, Yang, Hua, Qiao, Jingjuan, Pu, Fan, Jiang, Jie, Hubbard, Kendra, Hekmatyar, Khan, Langley, Jason, Salarian, Mani, Long, Robert C., Bryant, Robert G., Hu, Xiaoping Philip, Grossniklaus, Hans E., Liu, Zhi-Ren, Yang, Jenny J.

“…Significance Primary and metastatic liver cancers that are associated with high mortality rates and poor treatment responses are only diagnosed at late stages,…”
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BRAF, NRAS, and GNAQ Mutations in Conjunctival Melanocytic Nevi by Francis, Jasmine H, Grossniklaus, Hans E, Habib, Larissa A, Marr, Brian, Abramson, David H, Busam, Klaus J

“…To evaluate BRAF, NRAS, and GNAQ mutations in surgical specimens of common and blue conjunctival melanocytic nevi. Surgical specimens from 25 conjunctival…”
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So-called massive retinal gliosis: A critical review and reappraisal by Jakobiec, Frederick A., MD, DSc, Thanos, Aristomenis, MD, Stagner, Anna M., MD, Grossniklaus, Hans E., MD, Proia, Alan D., MD, PhD

“…Abstract Massive retinal gliosis, a nonneoplastic retinal glial proliferation, was first described in detail over 25 years ago, before the era of…”
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Development of a unique small molecule modulator of CXCR4 by Liang, Zhongxing, Zhan, Weiqiang, Zhu, Aizhi, Yoon, Younghyoun, Lin, Songbai, Sasaki, Maiko, Klapproth, Jan-Michael A, Yang, Hua, Grossniklaus, Hans E, Xu, Jianguo, Rojas, Mauricio, Voll, Ronald J, Goodman, Mark M, Arrendale, Richard F, Liu, Jin, Yun, C Chris, Snyder, James P, Liotta, Dennis C, Shim, Hyunsuk

“…Metastasis, the spread and growth of tumor cells to distant organ sites, represents the most devastating attribute and plays a major role in the morbidity and…”
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Histopathologic Grading of Anaplasia in Retinoblastoma by Mendoza, Pia R, Specht, Charles S, Hubbard, G. Baker, Wells, Jill R, Lynn, Michael J, Zhang, Qing, Kong, Jun, Grossniklaus, Hans E

“…Purpose To determine whether the degree of tumor anaplasia has prognostic value by evaluating its correlation with high-risk histopathologic features and…”
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