Search Results - "GROSSMAN, Robert B"

Research Progress of Polycyclic Polyprenylated Acylphloroglucinols by Yang, Xing-Wei, Grossman, Robert B, Xu, Gang

“…Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products sharing the mevalonate/methylerythritol phosphate and polyketide…”
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Structural Revision of Garcinielliptin Oxide and Garcinielliptone E by Grossman, Robert B, Yang, Xing-Wei

“…Previously, Lin et al. reported the isolation and structural determination of two triterpenoids, garcinielliptin oxide (GO) and garcinielliptone E (GE). Their…”
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Evidence for Modulation of Oxygen Rebound Rate in Control of Outcome by Iron(II)- and 2‑Oxoglutarate-Dependent Oxygenases by Pan, Juan, Wenger, Eliott S, Matthews, Megan L, Pollock, Christopher J, Bhardwaj, Minakshi, Kim, Amelia J, Allen, Benjamin D, Grossman, Robert B, Krebs, Carsten, Bollinger, J. Martin

“…Iron­(II)- and 2-oxoglutarate-dependent (Fe/2OG) oxygenases generate iron­(IV)-oxo (ferryl) intermediates that can abstract hydrogen from aliphatic carbons…”
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Installation of the Ether Bridge of Lolines by the Iron- and 2‑Oxoglutarate-Dependent Oxygenase, LolO: Regio- and Stereochemistry of Sequential Hydroxylation and Oxacyclization Reactions by Pan, Juan, Bhardwaj, Minakshi, Zhang, Bo, Chang, Wei-chen, Schardl, Christopher L, Krebs, Carsten, Grossman, Robert B, Bollinger, J. Martin

“…The core of the loline family of insecticidal alkaloids is the bicyclic pyrrolizidine unit with an additional strained ether bridge between carbons 2 and 7…”
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Enzymes from fungal and plant origin required for chemical diversification of insecticidal loline alkaloids in grass-Epichloë symbiota by Pan, Juan, Bhardwaj, Minakshi, Nagabhyru, Padmaja, Grossman, Robert B, Schardl, Christopher L

“…The lolines are a class of bioprotective alkaloids that are produced by Epichloë species, fungal endophytes of grasses. These alkaloids are saturated…”
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1,2-Diamination of Alkenes via 1,3-Dipolar Cycloaddition with Azidium Ions or Azides by Saryazdi, Setareh, Parkin, Sean, Grossman, Robert B.

“…We describe two new methods for the 1,2-diamination of alkenes. First, either an azidium ion (ArNN+NAr) undergoes 1,3-dipolar cycloaddition with an alkene to…”
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Polycyclic Polyprenylated Acylphloroglucinols by Ciochina, Roxana, Grossman, Robert B

“…Investigation of the chemical activity of plants used in herbal medicine, such as St John's Wort and hops, have revealed a class of compounds, polycyclic…”
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Revision of the Structure of Hypatulone A by NMR, Computations, and Biosynthetic Considerations by Yang, Xing-Wei, Grossman, Robert B

“…Recently, a paper in this journal reported the isolation and structure determination of hypatulone A. Several features of the proposed structure and…”
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Structure Revision of Type B Polycyclic Polyprenylated Acylphloroglucinols Fused to a Partly Reduced Furan Ring by Qiu, Yu-Feng, Grossman, Robert B., Yang, Xing-Wei

“…Four previous papers reported the isolation and structural determination of 10 polycyclic polyprenylated acylphloroglucinols (PPAPs), uraliones F, G, K, and O,…”
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Total synthesis and structural reassignment of garcinielliptone FC, a polycyclic polyprenylated acylphloroglucinol with diverse bioactivity by Luo, Yang, Grossman, Robert B, Nie, Xiao-Bin, Yang, Xing-Wei

“…Garcinielliptone FC (GFC) was assigned to be a type A polycyclic polyprenylated acylphloroglucinol (PPAP) and was found to exhibit diverse biological…”
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A Conformationally Restricted Gold(III) Complex Elicits Antiproliferative Activity in Cancer Cells by Gukathasan, Sailajah, Obisesan, Oluwatosin A., Saryazdi, Setareh, Ratliff, Libby, Parkin, Sean, Grossman, Robert B., Awuah, Samuel G.

“…Diamine ligands are effective structural scaffolds for tuning the reactivity of transition-metal complexes for catalytic, materials, and phosphorescent…”
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Polycyclic Polyprenylated Acylphloroglucinols Bearing a Lavandulyl-Derived Substituent from Garcinia xanthochymus Fruits by Xu, Zhi-Hong, Grossman, Robert B., Qiu, Yu-Feng, Luo, Yang, Lan, Tian, Yang, Xing-Wei

“…Many type B polycyclic polyprenylated acylphloroglucinols (PPAPs) bear a lavandulyl-derived substituent, and the configurational assignment of this side chain…”
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A New Synthetic Approach to the Polycyclic Polyprenylated Acylphloroglucinols by Ciochina, Roxana, Grossman, Robert B

“…The three-carbon α,α‘-annulation of a sterically hindered cyclic β-keto ester can be achieved by alkynylation with 3,3-diethoxypropyne, syn reduction of the…”
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An Unusual Ferryl Intermediate and Its Implications for the Mechanism of Oxacyclization by the Loline-Producing Iron(II)- and 2‑Oxoglutarate-Dependent Oxygenase, LolO by Pan, Juan, Wenger, Eliott S., Lin, Chi-Yun, Zhang, Bo, Sil, Debangsu, Schaperdoth, Irene, Saryazdi, Setareh, Grossman, Robert B., Krebs, Carsten, Bollinger, J. Martin

“…N-Acetylnorloline synthase (LolO) is one of several iron­(II)- and 2-oxoglutarate-dependent (Fe/2OG) oxygenases that catalyze sequential reactions of different…”
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Synthesis of 6,6‐ and 7,7‐Difluoro‐1‐acetamidopyrrolizidines and Their Oxidation Catalyzed by the Nonheme Fe Oxygenase LolO by Panth, Nabin, Wenger, Eliott S., Krebs, Carsten, Bollinger, J. Martin, Grossman, Robert B.

“…LolO, a 2‐oxoglutarate‐dependent nonheme Fe oxygenase, catalyzes both the hydroxylation of 1‐exo‐acetamidopyrrolizidine (AcAP), a pathway intermediate in the…”
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Structural Revision of Hyperibrin B and Hyperscabrones H and I by Biosynthetic Considerations, NMR Analysis, and Chemical Synthesis by Wang, Xiaohui, Nie, Xiao-Bin, Grossman, Robert B, Ji, Teng-Fei, Yang, Xing-Wei

“…Previously, Gao et al. reported the isolation and structural determination of three natural products, hyperibrin B (HB), hyperscabrone H (HH), and…”
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Loline alkaloids: Currencies of mutualism by Schardl, Christopher L., Grossman, Robert B., Nagabhyru, Padmaja, Faulkner, Jerome R., Mallik, Uma P.

“…Increasingly, fungal endophytes are recognized for their roles in plant protection. Several seed-borne endophytes of grasses (Poaceae) produce lolines, which…”
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Insights into the substrate specificity of plant peptide deformylase, an essential enzyme with potential for the development of novel biotechnology applications in agriculture by Dirk, Lynnette M A, Schmidt, Jack J, Cai, Yiying, Barnes, Jonathan C, Hanger, Katherine M, Nayak, Nihar R, Williams, Mark A, Grossman, Robert B, Houtz, Robert L, Rodgers, David W

“…The crystal structure of AtPDF1B [Arabidopsis thaliana PDF (peptide deformylase) 1B; EC 3.5.1.88], a plant specific deformylase, has been determined at a…”
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Ether bridge formation in loline alkaloid biosynthesis by Pan, Juan, Bhardwaj, Minakshi, Faulkner, Jerome R., Nagabhyru, Padmaja, Charlton, Nikki D., Higashi, Richard M., Miller, Anne-Frances, Young, Carolyn A., Grossman, Robert B., Schardl, Christopher L.

“…The LolO non-heme iron oxygenase is required to form the ether bridge of loline alkaloids. •Genomes were sequenced for four fungi with three different loline…”
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An unusually short inter-molecular N-H⋯N hydrogen bond in crystals of the hemi-hydro-chloride salt of 1- exo -acetamido-pyrrolizidine by Bhardwaj, Minakshi, Ai, Qianxiang, Parkin, Sean R, Grossman, Robert B

“…The title compound [systematic name: (1 *, 8 )-2-acetamidoocta-hydro-pyrrol-izin-4-ium chloride- -[(1 , 8 )-hexa-hydro-1 -pyrrolizin-2-yl)acetamide (1/1)], 2(C…”
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