Search Results - "GROSS, Michael L"

Mass Spectrometry-Based Protein Footprinting for Higher-Order Structure Analysis: Fundamentals and Applications by Liu, Xiaoran Roger, Zhang, Mengru Mira, Gross, Michael L

“…Proteins adopt different higher-order structures (HOS) to enable their unique biological functions. Understanding the complexities of protein higher-order…”
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The Application of Fluorine‐Containing Reagents in Structural Proteomics by Cheng, Ming, Guo, Chunyang, Gross, Michael L.

“…Structural proteomics refers to large‐scale mapping of protein structures in order to understand the relationship between protein sequence, structure, and…”
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Phycobilisomes Supply Excitations to Both Photosystems in a Megacomplex in Cyanobacteria by Liu, Haijun, Zhang, Hao, Niedzwiedzki, Dariusz M., Prado, Mindy, He, Guannan, Gross, Michael L., Blankenship, Robert E.

“…In photosynthetic organisms, photons are captured by light-harvesting antenna complexes, and energy is transferred to reaction centers where photochemical…”
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Antibody Binding Captures High Energy State of an Antigen: The Case of Nsp1 SARS-CoV-2 as Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry by Kant, Ravi, Mishra, Nawneet, Gross, Michael L

“…We describe an investigation using structural mass spectrometry (MS) of the impact of two antibodies, 15497 and 15498, binding the highly flexible SARS-CoV-2…”
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The entropic force generated by intrinsically disordered segments tunes protein function by Keul, Nicholas D., Oruganty, Krishnadev, Schaper Bergman, Elizabeth T., Beattie, Nathaniel R., McDonald, Weston E., Kadirvelraj, Renuka, Gross, Michael L., Phillips, Robert S., Harvey, Stephen C., Wood, Zachary A.

“…Protein structures are dynamic and can explore a large conformational landscape 1 , 2 . Only some of these structural substates are important for protein…”
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Modelling proteins’ hidden conformations to predict antibiotic resistance by Hart, Kathryn M., Ho, Chris M. W., Dutta, Supratik, Gross, Michael L., Bowman, Gregory R.

“…TEM β-lactamase confers bacteria with resistance to many antibiotics and rapidly evolves activity against new drugs. However, functional changes are not easily…”
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Nanoparticles and photochemistry for native-like transmembrane protein footprinting by Sun, Jie, Liu, Xiaoran Roger, Li, Shuang, He, Peng, Li, Weikai, Gross, Michael L.

“…Mass spectrometry-based footprinting can probe higher order structure of soluble proteins in their native states and serve as a complement to high-resolution…”
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Biochemical and HDX Mass Spectral Characterization of the SARS-CoV‑2 Nsp1 Protein by Mishra, Nawneet, Kant, Ravi, Leung, Daisy W., Gross, Michael L., Amarasinghe, Gaya K.

“…A major challenge in defining the pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is to better understand virally…”
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Near-atomic structure of a giant virus by Fang, Qianglin, Zhu, Dongjie, Agarkova, Irina, Adhikari, Jagat, Klose, Thomas, Liu, Yue, Chen, Zhenguo, Sun, Yingyuan, Gross, Michael L., Van Etten, James L., Zhang, Xinzheng, Rossmann, Michael G.

“…Although the nucleocytoplasmic large DNA viruses (NCLDVs) are one of the largest group of viruses that infect many eukaryotic hosts, the near-atomic resolution…”
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Native Electrospray and Electron-Capture Dissociation FTICR Mass Spectrometry for Top-Down Studies of Protein Assemblies by Zhang, Hao, Cui, Weidong, Wen, Jianzhong, Blankenship, Robert E, Gross, Michael L

“…The high sensitivity, extended mass range, and fast data acquisition/processing of mass spectrometry and its coupling with native electrospray ionization (ESI)…”
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Organic Solvents for Enhanced Proteolysis of Stable Proteins for Hydrogen–Deuterium Exchange Mass Spectrometry by Guo, Chunyang, Steinberg, Lindsey K, Henderson, Jeffrey P, Gross, Michael L

“…Protein digestion is a key challenge in mass spectrometry (MS)-based structural proteomics. Although using hydrogen–deuterium exchange kinetics with MS…”
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Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer by Shen, Guomin, Cui, Weidong, Zhang, Hao, Zhou, Fengbo, Huang, Wei, Liu, Qian, Yang, Yihu, Li, Shuang, Bowman, Gregory R, Sadler, J Evan, Gross, Michael L, Li, Weikai

“…Mass spectrometry and biochemical analyses reveal that the major form of VKOR found in cells features a disulfide bond between Cys51 and Cys132, and this…”
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Moral Dilemmas of Modern War: Torture, Assassination, and Blackmail in an Age of Asymmetric Conflict by Gross, Michael L.

“…Asymmetric conflict is changing the way that we practise and think about war. Torture, rendition, assassination, blackmail, extortion, direct attacks on…”
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From active duty to activism: how moral injury and combat trauma drive political activism and societal reintegration among Israeli veterans by Levy, Adi, Gross, Michael L

“…This article deals with combat experiences and their consequences and could be potentially disturbing. Moral injury (MI) is a severe form of combat trauma that…”
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Membrane Orientation of the FMO Antenna Protein from Chlorobaculum Tepidum as Determined by Mass Spectrometry-Based Footprinting by Wen, Jianzhong, Zhang, Hao, Gross, Michael L., Blankenship, Robert E., Fleming, Graham R.

“…The high excitation energy-transfer efficiency demanded in photosynthetic organisms relies on the optimal pigment-protein binding orientation in the individual…”
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Fast Photochemical Oxidation of Protein Footprints Faster than Protein Unfolding by Gau, Brian C, Sharp, Joshua S, Rempel, Don L, Gross, Michael L

“…Fast photochemical oxidation of proteins (FPOP) is a chemical footprinting method whereby exposed amino-acid residues are covalently labeled by oxidation with…”
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Mass Spectrometry-Based Structural Proteomics for Metal Ion/Protein Binding Studies by Lin, Yanchun, Gross, Michael L

“…Metal ions are critical for the biological and physiological functions of many proteins. Mass spectrometry (MS)-based structural proteomics is an ever-growing…”
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Pulsed hydrogen–deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Aβ) peptide aggregation by Zhang, Ying, Rempel, Don L., Zhang, Jun, Sharma, Anuj K., Mirica, Liviu M., Gross, Michael L.

“…Probing the conformational changes of amyloid beta (Aβ) peptide aggregation is challenging owing to the vast heterogeneity of the resulting soluble aggregates…”
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A Molecular Code for Identity in the Vomeronasal System by Fu, Xiaoyan, Yan, Yuetian, Xu, Pei S., Geerlof-Vidavsky, Ilan, Chong, Wongi, Gross, Michael L., Holy, Timothy E.

“…In social interactions among mammals, individuals are recognized by olfactory cues, but identifying the key signals among thousands of compounds remains a…”
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Native mass spectrometry of photosynthetic pigment–protein complexes by Zhang, Hao, Cui, Weidong, Gross, Michael L., Blankenship, Robert E.

“…Native mass spectrometry (MS), or as is sometimes called “native electrospray ionization” allows proteins in their native or near-native states in solution to…”
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