Search Results - "GROS, Frédéric"

The role of lysosomes in metabolic and autoimmune diseases by Gros, Frédéric, Muller, Sylviane

“…Lysosomes are catabolic organelles that contribute to the degradation of intracellular constituents through autophagy and of extracellular components through…”
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Pharmacological regulators of autophagy and their link with modulators of lupus disease by Gros, Frédéric, Muller, Sylviane

“…Autophagy is a central regulator of cell survival. It displays both anti‐ and pro‐death roles that are decisive in the maintenance of cell homeostasis…”
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Lymphocyte Autophagy in Homeostasis, Activation, and Inflammatory Diseases by Arbogast, Florent, Gros, Frédéric

“…Autophagy is a catabolic mechanism, allowing the degradation of cytoplasmic content lysosomal activity. Several forms of autophagy are described in mammals…”
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Effects of autophagy on joint inflammation by Gros, Frédéric

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Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes by Ghoroghi, Shima, Mary, Benjamin, Larnicol, Annabel, Asokan, Nandini, Klein, Annick, Osmani, Naël, Busnelli, Ignacio, Delalande, François, Paul, Nicodème, Halary, Sébastien, Gros, Frédéric, Fouillen, Laetitia, Haeberle, Anne-Marie, Royer, Cathy, Spiegelhalter, Coralie, André-Grégoire, Gwennan, Mittelheisser, Vincent, Detappe, Alexandre, Murphy, Kendelle, Timpson, Paul, Carapito, Raphaël, Blot-Chabaud, Marcel, Gavard, Julie, Carapito, Christine, Vitale, Nicolas, Lefebvre, Olivier, Goetz, Jacky G, Hyenne, Vincent

“…Cancer extracellular vesicles (EVs) shuttle at distance and fertilize pre-metastatic niches facilitating subsequent seeding by tumor cells. However, the link…”
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Beyond Anti-viral Effects of Chloroquine/Hydroxychloroquine by Gies, Vincent, Bekaddour, Nassima, Dieudonné, Yannick, Guffroy, Aurélien, Frenger, Quentin, Gros, Frédéric, Rodero, Mathieu Paul, Herbeuval, Jean-Philippe, Korganow, Anne-Sophie

“…As the world is severely affected by COVID-19 pandemic, the use of chloroquine and hydroxychloroquine in prevention or for the treatment of patients is allowed…”
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CD4 T cell autophagy is integral to memory maintenance by Murera, Diane, Arbogast, Florent, Arnold, Johan, Bouis, Delphine, Muller, Sylviane, Gros, Frédéric

“…Studies of mice deficient for autophagy in T cells since thymic development, concluded that autophagy is integral to mature T cell homeostasis. Basal survival…”
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Macroautophagy is deregulated in murine and human lupus T lymphocytes by Gros, Frédéric, Arnold, Johan, Page, Nicolas, Décossas, Marion, Korganow, Anne-Sophie, Martin, Thierry, Muller, Sylviane

“…Macroautophagy was recently shown to regulate both lymphocyte biology and innate immunity. In this study we sought to determine whether a deregulation of…”
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ATG5 is required for B cell polarization and presentation of particulate antigens by Arbogast, Florent, Arnold, Johan, Hammann, Philippe, Kuhn, Lauriane, Chicher, Johana, Murera, Diane, Weishaar, Justine, Muller, Sylviane, Fauny, Jean-Daniel, Gros, Frédéric

“…The involvement of macroautophagy/autophagy proteins in B-cell receptor (BCR) trafficking, although suspected, is not well understood. We show that ATG5…”
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Efferocytosis dysfunction in CXCL4-induced M4 macrophages: phenotypic insights in systemic sclerosis in vitro and in vivo by Le Tallec, Erwan, Bellamri, Nessrine, Lelong, Marie, Morzadec, Claudie, Frenger, Quentin, Ballerie, Alice, Cazalets, Claire, Lescoat, Alain, Gros, Frédéric, Lecureur, Valérie

“…Systemic sclerosis (SSc) is an autoimmune disease characterized by antinuclear antibody production, which has been linked to an excess of apoptotic cells,…”
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Sustained NKG2D engagement induces cross-tolerance of multiple distinct NK cell activation pathways by Coudert, Jérôme D., Scarpellino, Léonardo, Gros, Frédéric, Vivier, Eric, Held, Werner

“…NKG2D is a multisubunit activation receptor that allows natural killer (NK) cells to detect and eliminate stressed, infected, and transformed host cells…”
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Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis by Suffert, Guillaume, Malterer, Georg, Hausser, Jean, Viiliäinen, Johanna, Fender, Aurélie, Contrant, Maud, Ivacevic, Tomi, Benes, Vladimir, Gros, Frédéric, Voinnet, Olivier, Zavolan, Mihaela, Ojala, Päivi M, Haas, Juergen G, Pfeffer, Sébastien

“…Kaposi's sarcoma herpesvirus (KSHV) encodes a cluster of twelve micro (mi)RNAs, which are abundantly expressed during both latent and lytic infection. Previous…”
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Corrigendum: Lymphocyte Autophagy in Homeostasis, Activation, and Inflammatory Diseases by Arbogast, Florent, Gros, Frédéric

“…[This corrects the article DOI: 10.3389/fimmu.2018.01801.]…”
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B cells differentiate in human thymus and express AIRE by Gies, Vincent, Guffroy, Aurélien, MD, Danion, François, MD, Billaud, Philippe, MD, Keime, Céline, PhD, Fauny, Jean-Daniel, PhD, Susini, Sandrine, PhD, Soley, Anne, LT, Martin, Thierry, MD, PhD, Pasquali, Jean-Louis, MD, PhD, Gros, Frédéric, PhD, André-Schmutz, Isabelle, PhD, Soulas-Sprauel, Pauline, PharmD, PhD, Korganow, Anne-Sophie, MD, PhD

“…If relevant, AIRE expression in thymic B cells may repress or induce the expression of other genes, as the induction of TRAs expression in medullary thymic…”
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HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus by Page, Nicolas, Gros, Frédéric, Schall, Nicolas, Décossas, Marion, Bagnard, Dominique, Briand, Jean-Paul, Muller, Sylviane

“…The P140 phosphopeptide issued from the spliceosomal U1-70K small nuclear ribonucleoprotein protein displays protective properties in MRL/lpr lupus-prone mice…”
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Avian erythrocytes have functional mitochondria, opening novel perspectives for birds as animal models in the study of ageing by Stier, Antoine, Bize, Pierre, Schull, Quentin, Zoll, Joffrey, Singh, François, Geny, Bernard, Gros, Frédéric, Royer, Cathy, Massemin, Sylvie, Criscuolo, François

“…BACKGROUND: In contrast to mammalian erythrocytes, which have lost their nucleus and mitochondria during maturation, the erythrocytes of almost all other…”
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A Role for cis Interaction between the Inhibitory Ly49A Receptor and MHC Class I for Natural Killer Cell Education by Chalifour, Anick, Scarpellino, Léonardo, Back, Jonathan, Brodin, Petter, Devèvre, Estelle, Gros, Frédéric, Lévy, Frédéric, Leclercq, Georges, Höglund, Petter, Beermann, Friedrich, Held, Werner

“…Natural killer (NK) cells show enhanced functional competence when they express inhibitory receptors specific for inherited major histocompatibility complex…”
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A therapeutic peptide in lupus alters autophagic processes and stability of MHCII molecules in MRL/Ipr B cells by Page, Nicolas, Gros, Frédéric, Schall, Nicolas, Briand, Jean-Paul, Muller, Sylviane

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Soluble HLA-G molecules impair natural killer/dendritic cell crosstalk via inhibition of dendritic cells by Gros, Frédéric, Cabillic, Florian, Toutirais, Olivier, Maux, Amélie Le, Sebti, Yasmine, Amiot, Laurence

“…HLA-G molecules are known to exert immunosuppressive action on DC maturation and on NK cells, and can in consequence inhibit respectively T cell responses and…”
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Soluble HLA-G Molecules Are Increased during Acute Leukemia, Especially in Subtypes Affecting Monocytic and Lymphoid Lineages by Gros, Frédéric, Sebti, Yasmine, de Guiber, Sophie, Branger, Bernard, Bernard, Marc, Fauchet, Renée, Amiot, Laurence

“…Human leukocyte antigen G (HLA-G) molecules corresponding to nonclassic class I genes of the major histocompatibility complex exhibit immunomodulatory…”
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