Search Results - "GROH, Veronika"

Immunobiology and conflicting roles of the human NKG2D lymphocyte receptor and its ligands in cancer by El-Gazzar, Ahmed, Groh, Veronika, Spies, Thomas

“…Cancers adopt diverse strategies to safeguard their survival, which often involve blinding or incapacitating the immune response, thereby gaining battleground…”
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Pillars Article: Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA. Science . 1999. 285: 727-729 by Bauer, Stefan, Groh, Veronika, Wu, Jun, Steinle, Alexander, Phillips, Joseph H, Lanier, Lewis L, Spies, Thomas

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NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo by Lakshmikanth, Tadepally, Burke, Shannon, Ali, Talib Hassan, Kimpfler, Silvia, Ursini, Francesco, Ruggeri, Loredana, Capanni, Marusca, Umansky, Viktor, Paschen, Annette, Sucker, Antje, Pende, Daniela, Groh, Veronika, Biassoni, Roberto, Höglund, Petter, Kato, Masashi, Shibuya, Kazuko, Schadendorf, Dirk, Anichini, Andrea, Ferrone, Soldano, Velardi, Andrea, Kärre, Klas, Shibuya, Akira, Carbone, Ennio, Colucci, Francesco

“…NK cells use a variety of receptors to detect abnormal cells, including tumors and their metastases. However, in the case of melanoma, it remains to be…”
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Promoter Region Architecture and Transcriptional Regulation of the Genes for the MHC Class I-Related Chain A and B Ligands of NKG2D by Venkataraman, Gopalakrishnan M, Suciu, Dominic, Groh, Veronika, Boss, Jeremy M, Spies, Thomas

“…Ligands of the NKG2D receptor, which activates NK cells and costimulates effector T cells, are inducibly expressed under harmful conditions, such as…”
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Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB by Groh, Veronika, Rhinehart, Rebecca, Secrist, Heather, Bauer, Stefan, Grabstein, Kenneth H., Spies, Thomas

“…Human MHC class I-related molecules, MICA and MICB, are stress-induced antigens that are recognized by a subset of γδ T cells expressing the variable region V…”
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Major histocompatibility complex class I-related chain A/B (MICA/B) expression in tumor tissue and serum of pancreatic cancer: role of uric acid accumulation in gemcitabine-induced MICA/B expression by Xu, Xiulong, Rao, Geetha S, Groh, Veronika, Spies, Thomas, Gattuso, Paolo, Kaufman, Howard L, Plate, Janet, Prinz, Richard A

“…Major histocompatibility complex class I-related chain A and B (MICA/B) are two stress-inducible ligands that bind the immunoreceptor NKG2D and play an…”
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Stimulation of T Cell Autoreactivity by Anomalous Expression of NKG2D and Its MIC Ligands in Rheumatoid Arthritis by Groh, Veronika, Brühl, Anja, El-Gabalawy, Hani, Nelson, J. Lee, Spies, Thomas

“…Effector T cell responses can be modulated by competing positive or negative signals transduced by natural killer (NK) cell receptors. This raises the…”
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Control of Tumor Initiation by NKG2D Naturally Expressed on Ovarian Cancer Cells by Cai, Xin, Caballero-Benitez, Andrea, Gewe, Mesfin M, Jenkins, Isaac C, Drescher, Charles W, Strong, Roland K, Spies, Thomas, Groh, Veronika

“…Abstract Cancer cells may co-opt the NKG2D lymphocyte receptor to complement the presence of its ligands for autonomous stimulation of oncogenic signaling…”
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Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys by Rupert, Peter B., Buerger, Matthew, Girard, Emily J., Frutoso, Marie, Parrilla, Don, Ng, Kevin, Gooley, Theodore, Groh, Veronika, Strong, Roland K.

“…NKG2D and its ligands are critical regulators of protective immune responses controlling infections and cancer, defining a crucial immune signaling axis…”
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Interleukin 15 primes natural killer cells to kill via NKG2D and cPLA2 and this pathway is active in psoriatic arthritis by Tang, Fangming, Sally, Benjamin, Ciszewski, Cezary, Abadie, Valerie, Curran, Shane A, Groh, Veronika, Fitzgerald, Oliver, Winchester, Robert J, Jabri, Bana

“…NK cells are large granular lymphocytes that form a critical component of the innate immune system, whose functions include the killing of cells expressing…”
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Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells by Benitez, Andrea Caballero, Dai, Zhenpeng, Mann, Henning H, Reeves, Rebecca S, Margineantu, Daciana H, Gooley, Ted A, Groh, Veronika, Spies, Thomas

“…The stimulatory natural killer group 2 member D (NKG2D) lymphocyte receptor and its tumor-associated ligands are important mediators in the immune surveillance…”
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Autonomous stimulation of cancer cell plasticity by the human NKG2D lymphocyte receptor coexpressed with its ligands on cancer cells by Cai, Xin, Dai, Zhenpeng, Reeves, Rebecca S, Caballero-Benitez, Andrea, Duran, Kate L, Delrow, Jeffrey J, Porter, Peggy L, Spies, Thomas, Groh, Veronika

“…The stimulatory NKG2D receptor on lymphocytes promotes tumor immune surveillance by targeting ligands selectively induced on cancer cells. Progressing tumors…”
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Adenovirus E3/19K Promotes Evasion of NK Cell Recognition by Intracellular Sequestration of the NKG2D Ligands Major Histocompatibility Complex Class I Chain-Related Proteins A and B by MCSHARRY, Brian P, BURGERT, Hans-Gerhard, LITTLE, Ann-Margaret, WANG, Eddie C. Y, TOMASEC, Peter, WILKINSON, Gavin W. G, OWEN, Douglas P, STANTON, Richard J, PROD'HOMME, Virginie, SESTER, Martina, KOEBERNICK, Katja, GROH, Veronika, SPIES, Thomas, COX, Steven

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cutting Edge: NKG2D Receptors Induced by IL-15 Costimulate CD28-Negative Effector CTL in the Tissue Microenvironment by Roberts, Arthur I, Lee, Leanne, Schwarz, Eliezer, Groh, Veronika, Spies, Thomas, Ebert, Ellen C, Jabri, Bana

“…Unlike primary T cells in lymph nodes, effector CD8+ CTL in tissues do not express the costimulatory receptor CD28. We report that NKG2D, the receptor for…”
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Efficient Cross-Priming of Tumor Antigen-Specific T Cells by Dendritic Cells Sensitized with Diverse Anti-MICA Opsonized Tumor Cells by Groh, Veronika, Li, Yongqing Q., Cioca, Daniel, Hunder, Naomi N., Wang, Wei, Riddell, Stanley R., Yee, Cassian, Spies, Thomas, Thomas, E. Donnall

“…Dendritic cells (DCs) have the capacity to prime tumor-specific T cell responses and are considered as potentially effective vaccines for immunotherapy of…”
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Expression of Stress-induced MHC Class I Related Chain Molecules on Human Melanoma by Vetter, Claudia S., Groh, Veronika, Straten, Per thor, Spies, Thomas, Bröcker, Eva-B, Becker, Jürgen C.

“…Cellular immune responses to melanoma are tightly regulated and include specific T cell responses to self antigens such as Mart-1 and gp100. Thus, additional…”
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Soluble Major Histocompatibility Complex Class I-Related Chain B Molecules Are Increased and Correlate With Clinical Outcomes During Rhinovirus Infection in Healthy Subjects by Telcian, Aurica G., MD, PhD, Zdrenghea, Mihnea T., MD, PhD, Caramori, Gaetano, MD, PhD, Laza-Stanca, Vasile, MD, PhD, Message, Simon D., MD, PhD, Kebadze, Tatiana, MD, Kon, Onn M., MD, PhD, Groh, Veronika, PhD, Papi, Alberto, MD, PhD, FCCP, Johnston, Sebastian L., MD, PhD, Mallia, Patrick, MD, PhD, Stanciu, Luminita A., MD, PhD

“…BACKGROUND Surface major histocompatibility complex class I-related chain (MIC) A and B molecules are increased by IL-15 and have a role in the activation of…”
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MICA expressed by multiple myeloma and monoclonal gammopathy of undetermined significance plasma cells costimulates pamidronate-activated γδ lymphocytes by GIRLANDA, Stefania, FORTIS, Claudio, CALIGARIS CAPPIO, Federico, FERRARINI, Marina, BELLONI, Daniela, FERRERO, Elisabetta, TICOZZI, Paolo, SCIORATI, Clara, TRESOLDI, Moreno, VICARI, Aurelio, SPIES, Thomas, GROH, Veronika

“…Amino-biphosphonates (like pamidronate) activate human Vγ9/Vδ2 T lymphocytes and promote their cytotoxicity against multiple myeloma cells. T-cell receptor…”
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Clinicopathological Significance of Major Histocompatibility Complex Class I-Related Chain A and B Expression in Thyroid Cancer by Xu, Xiulong, Rao, Geetha, Gaffud, Michael J., Ding, Helen G., Maki, Guitta, Klingemann, Hans-G., Groh, Veronika, Spies, Thomas, Caillat-Zucman, Sophie, Gattuso, Paolo, Plate, Janet, Prinz, Richard A.

“…Context: Major histocompatibility complex class I-related chains A and B (MICA/B) are two stress-inducible ligands for the immunoreceptor NKG2D that is…”
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Crystal structure of a γδ T-cell receptor specific for the human MHC class I homolog MICA by Xu, Bin, Pizarro, Juan C, Holmes, Margaret A, McBeth, Christine, Groh, Veronika, Spies, Thomas, Strong, Roland K

“…γδ T cells play important roles in bridging innate and adaptive immunity, but their recognition mechanisms remain poorly understood. Human γδ T cells of the…”
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