Paracoccidioidomycosis: A comparative study of the evolutionary serologic, clinical an radiologic results for patients treated with ketoconazole or amphotericin B plus sulfonamides

Paracoccidioidomycosis: A comparative study of the evolutionary serologic, clinical an radiologic results for patients treated with ketoconazole or amphotericin B plus sulfonamides

A comparative study of two groups of patients with paracoccidioidomycosis was carried out with the objective of comparing the evolutionary serologic, clinical and radiologic results after 6, 12, 15 and 18 months of treatment with ketoconazole (22 patients) or amphotericin B plus sulfonamides (32 pat...

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Bibliographic Details
Published in:Mycopathologia (1975) Vol. 89; no. 1; pp. 19 - 23
Main Authors: MARQUES, S. A, DILLON, N. L, CURI, P. R, FRANCO, M. F, HABERMANN, M. C, LASTORIA, J. C, STOLF, H. O, MARCONDES, J, GRIZZO, W, SILVA, N. C. A, CAVARIANI, M. R
Format: Journal Article
Language:English
Published: Dordrecht Springer 1985
Subjects:
Adolescent
Adult
Aged
Amphotericin B - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Biological and medical sciences
Blastomycoses and paracoccidioidomycosis
Child
Drug Evaluation
Drug Therapy, Combination
Female
Human mycoses
Humans
Infectious diseases
Ketoconazole - therapeutic use
Male
Medical sciences
Middle Aged
Mycoses
Paracoccidioidomycosis - drug therapy
Pharmacology. Drug treatments
Sulfadimethoxine - therapeutic use
Sulfadoxine - therapeutic use
Sulfonamides - therapeutic use
Tropical medicine
Tropical mycoses
South America
Human
Sulfanilamide derivatives
Blastomycosis
Mycosis
Infection
Antifungal agent
Chemotherapy
Treatment
Brazil
Evolution
Paracoccidioidomycosis
Comparative study
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Summary:A comparative study of two groups of patients with paracoccidioidomycosis was carried out with the objective of comparing the evolutionary serologic, clinical and radiologic results after 6, 12, 15 and 18 months of treatment with ketoconazole (22 patients) or amphotericin B plus sulfonamides (32 patients). The serologic data analyzed as a whole showed a tendency to sharper drops in antibody titers in the patients treated with ketoconazole. Clinically patients treated with ketoconazole fared better but the differences were not statistically significant. No statistical difference was detected between groups in terms of the results of radiologic evolution.
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ISSN:0301-486X
1573-0832
DOI:10.1007/bf00437128