Search Results - "GRISWOLD, Michael"

Spermatogenesis: The Commitment to Meiosis by Griswold, Michael D

“…Mammalian spermatogenesis requires a stem cell pool, a period of amplification of cell numbers, the completion of reduction division to haploid cells…”
Get full text

50 years of spermatogenesis: Sertoli cells and their interactions with germ cells by Griswold, Michael D

“…The complex morphology of the Sertoli cells and their interactions with germ cells has been a focus of investigators since they were first described by Enrico…”
Get full text

Cellular and molecular basis for the action of retinoic acid in spermatogenesis by Griswold, Michael D

“…Spermatogenesis is a highly organized and regulated process that requires the constant production of millions of gametes over the reproductive lifetime of the…”
Get full text

Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study by Mahajan, Uma V, Varma, Vijay R, Griswold, Michael E, Blackshear, Chad T, An, Yang, Oommen, Anup M, Varma, Sudhir, Troncoso, Juan C, Pletnikova, Olga, O'Brien, Richard, Hohman, Timothy J, Legido-Quigley, Cristina, Thambisetty, Madhav

“…There is growing evidence that Alzheimer disease (AD) is a pervasive metabolic disorder with dysregulation in multiple biochemical pathways underlying its…”
Get full text

Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis by Chen, Yao, Zheng, Yuxuan, Gao, Yun, Lin, Zhen, Yang, Suming, Wang, Tongtong, Wang, Qiu, Xie, Nannan, Hua, Rong, Liu, Mingxi, Sha, Jiahao, Griswold, Michael D., Li, Jinsong, Tang, Fuchou, Tong, Ming-Han

“…A systematic interrogation of male germ cells is key to complete understanding of molecular mechanisms governing spermatogenesis and the development of new…”
Get full text

The key role of vitamin A in spermatogenesis by Hogarth, Cathryn A, Griswold, Michael D

“…Spermatogenesis in adult mammals is highly organized, with the goal being continual sperm production. Vertebrate testes are arranged into recurring cellular…”
Get full text

Retinoic acid activates two pathways required for meiosis in mice by Koubova, Jana, Hu, Yueh-Chiang, Bhattacharyya, Tanmoy, Soh, Y Q Shirleen, Gill, Mark E, Goodheart, Mary L, Hogarth, Cathryn A, Griswold, Michael D, Page, David C

“…In all sexually reproducing organisms, cells of the germ line must transition from mitosis to meiosis. In mice, retinoic acid (RA), the extrinsic signal for…”
Get full text

Temporal maturation of Sertoli cells during the establishment of the cycle of the seminiferous epithelium by Havel, Shelby L, Griswold, Michael D

“…Sertoli cells, omnipresent, somatic cells within the seminiferous tubules of the mammalian testis are essential to male fertility. Sertoli cells maintain the…”
Get full text

Initiating Meiosis: The Case for Retinoic Acid by GRISWOLD, Michael D, HOGARTH, Cathryn A, BOWLES, Josephine, KOOPMAN, Peter

“…The requirement for vitamin A in reproduction and development was first determined from studies of nutritional deficiencies. Subsequent research has shown that…”
Get full text

Processive pulses of retinoic acid propel asynchronous and continuous murine sperm production by Hogarth, Cathryn A, Arnold, Samuel, Kent, Travis, Mitchell, Debra, Isoherranen, Nina, Griswold, Michael D

“…The asynchronous cyclic nature of spermatogenesis is essential for continual sperm production and is one of the hallmarks of mammalian male fertility. While…”
Get full text

DMRT1 prevents female reprogramming in the postnatal mammalian testis by Matson, Clinton K., Murphy, Mark W., Sarver, Aaron L., Griswold, Michael D., Bardwell, Vivian J., Zarkower, David

“…DMRT1 loss is cue for sex swap The presence or absence of the Y-chromosome gene Sry determines whether precursor cells differentiate into testicular Sertoli…”
Get full text

Intact piRNA pathway prevents L1 mobilization in male meiosis by Newkirk, Simon J., Lee, Suman, Grandi, Fiorella C., Gaysinskaya, Valeriya, Rosser, James M., Vanden Berg, Nicole, Hogarth, Cathryn A., Marchetto, Maria C. N., Muotri, Alysson R., Griswold, Michael D., Ye, Ping, Bortvin, Alex, Gage, Fred H., Boeke, Jef D., An, Wenfeng

“…The PIWI-interacting RNA (piRNA) pathway is essential for retrotransposon silencing. In piRNA-deficient mice, L1-overexpressing male germ cells exhibit…”
Get full text

The Mammalian Doublesex Homolog DMRT1 Is a Transcriptional Gatekeeper that Controls the Mitosis versus Meiosis Decision in Male Germ Cells by Matson, Clinton K., Murphy, Mark W., Griswold, Michael D., Yoshida, Shosei, Bardwell, Vivian J., Zarkower, David

“…The switch from mitosis to meiosis is a unique feature of germ cell development. In mammals, meiotic initiation requires retinoic acid (RA), which activates…”
Get full text

The role of retinoic acid in the commitment to meiosis by Gewiss, Rachel, Schleif, M, Griswold, Michael

“…Male meiosis is a complex process whereby spermatocytes undergo cell division to form haploid cells. This review focuses on the role of retinoic acid (RA) in…”
Get full text

Two miRNA Clusters, Mir-17-92 (Mirc1) and Mir-106b-25 (Mirc3), Are Involved in the Regulation of Spermatogonial Differentiation in Mice by TONG, Ming-Han, MITCHELL, Debra Ann, MCGOWAN, Samantha Dawn, EVANOFF, Ryan, GRISWOLD, Michael D

“…Increasing evidence indicates that microRNAs (miRNAs) may be critical players in spermatogenesis. The miRNA expression profiles of THY1(+)-enriched…”
Get full text

MEIOSIN: A New Watchman of Meiotic Initiation in Mammalian Germ Cells by Oatley, Jon M., Griswold, Michael D.

“…The capacity to undergo meiosis defines vertebrate germ cells, yet mechanisms driving initiation of this specialized process are largely undefined. In this…”
Get full text

RiboTag analysis of actively translated mRNAs in Sertoli and Leydig cells in vivo by Sanz, Elisenda, Evanoff, Ryan, Quintana, Albert, Evans, Elizabeth, Miller, Jeremy A, Ko, Chemyong, Amieux, Paul S, Griswold, Michael D, McKnight, G Stanley

“…Male spermatogenesis is a complex biological process that is regulated by hormonal signals from the hypothalamus (GnRH), the pituitary gonadotropins (LH and…”
Get full text

Systematic Review for the 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines by Reboussin, David M, Allen, Norrina B, Griswold, Michael E, Guallar, Eliseo, Hong, Yuling, Lackland, Daniel T, Miller, Edgar (Pete) R, Polonsky, Tamar, Thompson-Paul, Angela M, Vupputuri, Suma

“…OBJECTIVE—To review the literature systematically and perform meta-analyses to address these questions1) Is there evidence that self-measured blood pressure…”
Get full text

Cycles, waves, and pulses: Retinoic acid and the organization of spermatogenesis by Gewiss, Rachel, Topping, Traci, Griswold, Michael D.

“…Background Spermatogenesis in mammals is organized in a manner that maximizes sperm production. The central aspect of this organization is the cycle of the…”
Get full text

A comparison of manual tracing and FreeSurfer for estimating hippocampal volume over the adult lifespan by Schmidt, Mike F, Storrs, Judd M, Freeman, Kevin B, Jack, Clifford R, Turner, Stephen T, Griswold, Michael E, Mosley, Thomas H

“…MRI has become an indispensable tool for brain volumetric studies, with the hippocampus an important region of interest. Automation of the MRI segmentation…”
Get full text