Search Results - "GRIPPO, Paul"

Pancreatic cancer subtypes: a roadmap for precision medicine by Torres, Carolina, Grippo, Paul J

“…Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cause of cancer-related deaths by 2020. Although it has traditionally been approached…”
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A New SET Piece in Cancer Development by Grippo, Paul J.

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TGF-β: Duality of Function Between Tumor Prevention and Carcinogenesis by PRINCIPE, Daniel R, DOLL, Jennifer A, BAUER, Jessica, JUNG, Barbara, MUNSHI, Hidayatullah G, BARTHOLIN, Laurent, PASCHE, Boris, CHUNG LEE, GRIPPO, Paul J

“…Several mechanisms underlying tumor progression have remained elusive, particularly in relation to transforming growth factor beta (TGF-β). Although TGF-β…”
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Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy by Principe, Daniel R, Narbutis, Matthew, Kumar, Sandeep, Park, Alex, Viswakarma, Navin, Dorman, Matthew J, Kamath, Suneel D, Grippo, Paul J, Fishel, Melissa L, Hwang, Rosa F, Thummuri, Dinesh, Underwood, Patrick W, Munshi, Hidayatullah G, Trevino, Jose G, Rana, Ajay

“…Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related death with a median survival time of 6-12 months. Most patients present with…”
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TGFβ Blockade Augments PD-1 Inhibition to Promote T-Cell-Mediated Regression of Pancreatic Cancer by Principe, Daniel R, Park, Alex, Dorman, Matthew J, Kumar, Sandeep, Viswakarma, Navin, Rubin, Jonathan, Torres, Carolina, McKinney, Ronald, Munshi, Hidayatullah G, Grippo, Paul J, Rana, Ajay

“…Pancreatic ductal adenocarcinoma (PDAC) remains remarkably lethal with a 5-year survival rate of 8%. This is mainly attributed to the late stage of…”
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The role of coagulome in the tumor immune microenvironment by Wahab, Riajul, Mahedi Hasan, Md, Azam, Zulfikar, Grippo, Paul J., Al-Hilal, Taslim A.

“…[Display omitted] The rising incidence and persistent thrombosis in multiple cancers including those that are immunosuppressive highlight the need for…”
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TGFβ Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis by Principe, Daniel R, DeCant, Brian, Mascariñas, Emman, Wayne, Elizabeth A, Diaz, Andrew M, Akagi, Naomi, Hwang, Rosa, Pasche, Boris, Dawson, David W, Fang, Deyu, Bentrem, David J, Munshi, Hidayatullah G, Jung, Barbara, Grippo, Paul J

“…In early pancreatic carcinogenesis, TGFβ acts as a tumor suppressor due to its growth-inhibitory effects in epithelial cells. However, in advanced disease,…”
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Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice by Guerra, Carmen, Schuhmacher, Alberto J., Cañamero, Marta, Grippo, Paul J., Verdaguer, Lena, Pérez-Gallego, Lucía, Dubus, Pierre, Sandgren, Eric P., Barbacid, Mariano

“…Pancreatic ductal adenocarcinoma (PDA), one of the deadliest human cancers, often involves somatic activation of K- Ras oncogenes. We report that selective…”
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Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation by Gounaris, Elias, Heiferman, Michael J, Heiferman, Jeffrey R, Shrivastav, Manisha, Vitello, Dominic, Blatner, Nichole R, Knab, Lawrence M, Phillips, Joseph D, Cheon, Eric C, Grippo, Paul J, Khazaie, Khashayarsha, Munshi, Hidayatullah G, Bentrem, David J

“…Leukotrienes and prostaglandins, products of arachidonic acid metabolism, sustain both systemic and lesion-localized inflammation. Tumor-associated…”
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Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development by Viswakarma, Navin, Sondarva, Gautam, Principe, Daniel R., Nair, Rakesh Sathish, Kumar, Sandeep, Singh, Sunil Kumar, Das, Subhasis, Sinha, Subhash C., Grippo, Paul J., Grimaldo, Sam, Giulianotti, Pier Cristoforo, Rana, Basabi, Rana, Ajay

“…The transcription factor Glioma-Associated Oncogene Homolog 1 (GLI1) is activated by sonic hedgehog (SHH) cascade and is an established driver of pancreatic…”
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Pigment Epithelium-Derived Factor (PEDF) as a Regulator of Wound Angiogenesis by Michalczyk, Elizabeth R., Chen, Lin, Fine, David, Zhao, Yan, Mascarinas, Emman, Grippo, Paul J., DiPietro, Luisa A.

“…Although the inflammatory and proliferative phases of wound healing have been well described, much less is known about how healing resolves. During the…”
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MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3 by Singh, Sunil Kumar, Kumar, Sandeep, Viswakarma, Navin, Principe, Daniel R., Das, Subhasis, Sondarva, Gautam, Nair, Rakesh Sathish, Srivastava, Piush, Sinha, Subhash C., Grippo, Paul J., Thatcher, Gregory R. J., Rana, Basabi, Rana, Ajay

“…MAP4K4 is a Ste20 member and reported to play important roles in various pathologies, including in cancer. However, the mechanism by which MAP4K4 promotes…”
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Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase by Knab, Lawrence M, Grippo, Paul J, Bentrem, David J

“…The interplay between inflammation and cancer progression is a growing area of research. A combination of clinical, epidemiological, and basic science…”
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Three-Dimensional Collagen I Promotes Gemcitabine Resistance in Pancreatic Cancer through MT1-MMP― Mediated Expression of HMGA2 by DANGI-GARIMELLA, Surabhi, KRANTZ, Seth B, BARRON, Morgan R, SHIELDS, Mario A, HEIFERMAN, Michael J, GRIPPO, Paul J, BENTREM, David J, MUNSHI, Hidayatullah G

“…One of the hallmarks of human pancreatic ductal adenocarcinoma (PDAC) is its pronounced type I collagen-rich fibrotic reaction. Although recent reports have…”
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TM4SF18 is aberrantly expressed in pancreatic cancer and regulates cell growth by Singhal, Megha, Khatibeghdami, Mahsa, Principe, Daniel R, Mancinelli, Georgina E, Schachtschneider, Kyle M, Schook, Lawrence B, Grippo, Paul J, Grimaldo, Sam R

“…Current therapies for pancreatic ductal adenocarcinoma (PDAC) only modestly impact survival and can be highly toxic. A greater understanding of the molecules…”
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A portable pen-sized instrumentation to measure stiffness of soft tissues in vivo by Li, Zhengwei, Tofangchi, Alireza, Stavins, Robert A., Emon, Bashar, McKinney, Ronald D., Grippo, Paul J., Saif, M. Taher A.

“…Quantitative assessment of soft tissue elasticity is crucial to a broad range of applications, such as biomechanical modeling, physiological monitoring, and…”
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Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway by Ding, Yongzeng, Mullapudi, Bhargava, Torres, Carolina, Mascariñas, Emman, Mancinelli, Georgina, Diaz, Andrew M, McKinney, Ronald, Barron, Morgan, Schultz, Michelle, Heiferman, Michael, Wojtanek, Mireille, Adrian, Kevin, DeCant, Brian, Rao, Sambasiva, Ouellette, Michel, Tsao, Ming-Sound, Bentrem, David J, Grippo, Paul J

“…Pancreatic cancer remains a daunting foe despite a vast number of accumulating molecular analyses regarding the mutation and expression status of a variety of…”
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Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer by Staudacher, Jonas J., Bauer, Jessica, Jana, Arundhati, Tian, Jun, Carroll, Timothy, Mancinelli, Georgina, Özden, Özkan, Krett, Nancy, Guzman, Grace, Kerr, David, Grippo, Paul, Jung, Barbara

“…Advanced colorectal cancer (CRC) remains a critical health care challenge worldwide. Various TGF-β superfamily members are important in colorectal cancer…”
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p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity by Torres, Carolina, Mancinelli, Georgina, Cordoba-Chacon, Jose, Viswakarma, Navin, Castellanos, Karla, Grimaldo, Sam, Kumar, Sandeep, Principe, Daniel, Dorman, Matthew J., McKinney, Ronald, Hirsch, Emilio, Dawson, David, Munshi, Hidayatullah G., Rana, Ajay, Grippo, Paul J.

“…Pancreatic ductal adenocarcinoma (PDAC) is notorious for its poor survival and resistance to conventional therapies. PI3K signaling is implicated in both…”
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Role of stromal activin A in human pancreatic cancer and metastasis in mice by Mancinelli, Georgina, Torres, Carolina, Krett, Nancy, Bauer, Jessica, Castellanos, Karla, McKinney, Ron, Dawson, David, Guzman, Grace, Hwang, Rosa, Grimaldo, Sam, Grippo, Paul, Jung, Barbara

“…Pancreatic ductal adenocarcinoma (PDAC) has extensive stromal involvement and remains one of the cancers with the highest mortality rates. Activin A has been…”
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