Search Results - "GRIMSBY, JOSEPH"

The dynamic plasticity of insulin production in β-cells by Boland, Brandon B, Rhodes, Christopher J, Grimsby, Joseph S

“…Abstract Background Although the insulin-producing pancreatic β-cells are quite capable of adapting to both acute and chronic changes in metabolic demand,…”
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BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis by Gustafson, Birgit, Hammarstedt, Ann, Hedjazifar, Shahram, Hoffmann, Jenny M, Svensson, Per-Arne, Grimsby, Joseph, Rondinone, Cristina, Smith, Ulf

“…The limited expandability of subcutaneous adipose tissue, due to reduced ability to recruit and differentiate new adipocytes, prevents its buffering effect in…”
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Differences in levels of phosphatidylinositols in healthy and stable Coronary Artery Disease subjects revealed by HILIC-MRM method with SERRF normalization by Huang, Yue, Mu, Ruipeng, Wen, David, Grimsby, Joseph S, Liang, Meina, Rosenbaum, Anton I

“…Quantification of endogenous biomarkers in clinical studies requires careful evaluation of a number of assay performance parameters. Comparisons of absolute…”
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Characterization of Signaling Pathways Associated with Pancreatic β-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice by Kang, Taewook, Boland, Brandon B., Jensen, Pia, Alarcon, Cristina, Nawrocki, Arkadiusz, Grimsby, Joseph S., Rhodes, Christopher J., Larsen, Martin R.

“…An unbiased quantitative profiling of the protein expression, phosphorylation, and sialylation events that occur upon β-cell adaptive flexibility during the…”
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Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia by Kang, Taewook, Boland, Brandon B, Alarcon, Cristina, Grimsby, Joseph S, Rhodes, Christopher J, Larsen, Martin R

“…For the treatment of patients with prediabetes or diabetes, clinical evidence has emerged that β-cell function can be restored by glucose-lowering therapeutic…”
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β-Cell Control of Insulin Production During Starvation-Refeeding in Male Rats by Boland, Brandon B, Brown, Charles, Alarcon, Cristina, Demozay, Damien, Grimsby, Joseph S, Rhodes, Christopher J

“…Abstract Mammalian metabolism has evolved to adapt to changes in nutrient status. Insulin, the key anabolic hormone, facilitates intracellular storage of…”
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The prevalence of low muscle mass associated with obesity in the USA by Murdock, Dana J, Wu, Ning, Grimsby, Joseph S, Calle, Roberto A, Donahue, Stephen, Glass, David J, Sleeman, Mark W, Sanchez, Robert J

“…Sarcopenia is defined as age-related low muscle mass and function, and can also describe the loss of muscle mass in certain medical conditions, such as…”
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Pancreatic β-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes by Boland, Brandon B, Brown, Jr, Charles, Boland, Michelle L, Cann, Jennifer, Sulikowski, Michal, Hansen, Gitte, Grønlund, Rikke V, King, Wanda, Rondinone, Cristina, Trevaskis, James, Rhodes, Christopher J, Grimsby, Joseph S

“…The onset of common obesity-linked type 2 diabetes (T2D) is marked by exhaustive failure of pancreatic β-cell functional mass to compensate for insulin…”
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1200-P: The Prevalence of Obesity-Associated Loss of Lean Muscle Mass by MURDOCK, DANA J., WU, NING, GLASS, DAVID J., GRIMSBY, JOSEPH S., CALLE, ROBERTO A., DONAHUE, STEPHEN, SLEEMAN, MARK, SANCHEZ, ROBERT J.

“…Sarcopenia, originally defined as age-related low muscle mass and function, has also been used to describe the loss of muscle mass and quality among certain…”
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Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis by Boland, Michelle L., Laker, Rhianna C., Mather, Karly, Nawrocki, Arkadiusz, Oldham, Stephanie, Boland, Brandon B., Lewis, Hilary, Conway, James, Naylor, Jacqueline, Guionaud, Silvia, Feigh, Michael, Veidal, Sanne S., Lantier, Louise, McGuinness, Owen P., Grimsby, Joseph, Rondinone, Cristina M., Jermutus, Lutz, Larsen, Martin R., Trevaskis, James L., Rhodes, Christopher J.

“…Non-alcoholic fatty liver disease and steatohepatitis are highly associated with obesity and type 2 diabetes mellitus. Cotadutide, a glucagon-like protein-1…”
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Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease by Pechenov, Sergei, Revell, Jefferson, Will, Sarah, Naylor, Jacqueline, Tyagi, Puneet, Patel, Chandresh, Liang, Lihuan, Tseng, Leo, Huang, Yue, Rosenbaum, Anton I., Balic, Kemal, Konkar, Anish, Grimsby, Joseph, Subramony, J. Anand

“…Peptide therapeutics are increasingly used in the treatment of disease, but their administration by injection reduces patient compliance and convenience,…”
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A novel glucagon‐like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice by Valdecantos, M. Pilar, Pardo, Virginia, Ruiz, Laura, Castro‐Sánchez, Luis, Lanzón, Borja, Fernández‐Millán, Elisa, García‐Monzón, Carmelo, Arroba, Ana I., González‐Rodríguez, Águeda, Escrivá, Fernando, Álvarez, Carmen, Rupérez, Francisco J., Barbas, Coral, Konkar, Anish, Naylor, Jacqui, Hornigold, David, Santos, Ana Dos, Bednarek, Maria, Grimsby, Joseph, Rondinone, Cristina M., Valverde, Ángela M.

“…Because nonalcoholic steatohepatitis (NASH) is associated with impaired liver regeneration, we investigated the effects of G49, a dual glucagon‐like…”
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Pancreatic Beta Cells in Very Old Mice Retain Capacity for Compensatory Proliferation by Stolovich-Rain, Miri, Hija, Ayat, Grimsby, Joseph, Glaser, Benjamin, Dor, Yuval

“…Recent studies suggested that in old mice, beta cells lose their regenerative potential and cannot respond to mitogenic triggers. These studies examined beta…”
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High-throughput mediation analysis of human proteome and metabolome identifies mediators of post-bariatric surgical diabetes control by Dreyfuss, Jonathan M., Yuchi, Yixing, Dong, Xuehong, Efthymiou, Vissarion, Pan, Hui, Simonson, Donald C., Vernon, Ashley, Halperin, Florencia, Aryal, Pratik, Konkar, Anish, Sebastian, Yinong, Higgs, Brandon W., Grimsby, Joseph, Rondinone, Cristina M., Kasif, Simon, Kahn, Barbara B., Foster, Kathleen, Seeley, Randy, Goldfine, Allison, Djordjilović, Vera, Patti, Mary Elizabeth

“…To improve the power of mediation in high-throughput studies, here we introduce High-throughput mediation analysis (Hitman), which accounts for direction of…”
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LOX-1: A potential driver of cardiovascular risk in SLE patients by Sagar, Divya, Gaddipati, Ranjitha, Ongstad, Emily L, Bhagroo, Nicholas, An, Ling-Ling, Wang, Jingya, Belkhodja, Mehdi, Rahman, Saifur, Manna, Zerai, Davis, Michael A, Hasni, Sarfaraz, Siegel, Richard, Sanjuan, Miguel, Grimsby, Joseph, Kolbeck, Roland, Karathanasis, Sotirios, Sims, Gary P, Gupta, Ruchi

“…Traditional cardiovascular disease (CVD) risk factors, such as hypertension, dyslipidemia and diabetes do not explain the increased CVD burden in systemic…”
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Blocking endothelial lipase with monoclonal antibody MEDI5884 durably increases high density lipoprotein in nonhuman primates and in a phase 1 trial by Le Lay, John E, Du, Qun, Mehta, Minal B, Bhagroo, Nicholas, Hummer, B Timothy, Falloon, Judith, Carlson, Glenn, Rosenbaum, Anton I, Jin, ChaoYu, Kimko, Holly, Tsai, Lan-Feng, Novick, Steven, Cook, Bill, Han, David, Han, Chang Yeop, Vaisar, Tomas, Chait, Alan, Karathanasis, Sotirios K, Rhodes, Christopher J, Hirshberg, Boaz, Damschroder, Melissa M, Hsia, Judith, Grimsby, Joseph S

“…Cardiovascular disease (CVD) is the leading global cause of death, and treatments that further reduce CV risk remain an unmet medical need. Epidemiological…”
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The Network of Glucokinase-Expressing Cells in Glucose Homeostasis and the Potential of Glucokinase Activators for Diabetes Therapy by Matschinsky, Franz M, Magnuson, Mark A, Zelent, Dorothy, Jetton, Tom L, Doliba, Nicolai, Han, Yi, Taub, Rebecca, Grimsby, Joseph

“…The Network of Glucokinase-Expressing Cells in Glucose Homeostasis and the Potential of Glucokinase Activators for Diabetes Therapy Franz M. Matschinsky 1 ,…”
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Discovery of PiragliatinFirst Glucokinase Activator Studied in Type 2 Diabetic Patients by Sarabu, Ramakanth, Bizzarro, Fred T, Corbett, Wendy L, Dvorozniak, Mark T, Geng, Wanping, Grippo, Joseph F, Haynes, Nancy-Ellen, Hutchings, Stanley, Garofalo, Lisa, Guertin, Kevin R, Hilliard, Darryl W, Kabat, Marek, Kester, Robert F, Ka, Wang, Liang, Zhenmin, Mahaney, Paige E, Marcus, Linda, Matschinsky, Franz M, Moore, David, Racha, Jagdish, Radinov, Roumen, Ren, Yi, Qi, Lida, Pignatello, Michael, Spence, Cheryl L, Steele, Thomas, Tengi, John, Grimsby, Joseph

“…Glucokinase (GK) activation as a potential strategy to treat type 2 diabetes (T2D) is well recognized. Compound 1, a glucokinase activator (GKA) lead that we…”
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Extremes of Clinical and Enzymatic Phenotypes in Children With Hyperinsulinism Caused by Glucokinase Activating Mutations by SAYED, Samir, LANGDON, David R, STANLEY, Charles A, ODILI, Stella, PAN CHEN, BUETTGER, Carol, SCHIFFMAN, Alisa B, SUCHI, Mariko, TAUB, Rebecca, GRIMSBY, Joseph, MATSCHINSKY, Franz M

“…Extremes of Clinical and Enzymatic Phenotypes in Children With Hyperinsulinism Caused by Glucokinase Activating Mutations Samir Sayed 1 , David R. Langdon 2 ,…”
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Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics by Doliba, Nicolai M, Qin, Wei, Najafi, Habiba, Liu, Chengyang, Buettger, Carol W, Sotiris, Johanna, Collins, Heather W, Li, Changhong, Stanley, Charles A, Wilson, David F, Grimsby, Joseph, Sarabu, Ramakanth, Naji, Ali, Matschinsky, Franz M

“…It was reported previously that isolated human islets from individuals with type 2 diabetes mellitus (T2DM) show reduced glucose-stimulated insulin release. To…”
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