Search Results - "GRIMAUD, J. A"

Heparin Decreases the Blood Clearance of Interferon-γ and Increases Its Activity by Limiting the Processing of Its Carboxyl-terminal Sequence by Lortat-Jacob, Hugues, Baltzer, Frederic, Grimaud, Jean-Alexis

“…Interferon-γ (IFN-γ) binds with high affinity to heparan sulfate and heparin molecules through its carboxyl-terminal domain. In vivo, IFN-γ is eliminated from…”
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Lysyl oxidase gene expression in the stromal reaction to in situ and invasive ductal breast carcinoma by Peyrol, S, Raccurt, M, Gerard, F, Gleyzal, C, Grimaud, JA, Sommer, P

“…Lysyl oxidase is involved in the main pathway of collagen and elastin cross-linking: it has a role in the maturation of fibrillar matrix proteins in fibrosing…”
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A histological semiquantitative scoring system for evaluation of hepatic fibrosis in needle liver biopsy specimens: comparison with morphometric studies by Chevallier, M, Guerret, S, Chossegros, P, Gerard, F, Grimaud, J A

“…The evaluation of hepatic fibrosis on histological sections is of great interest for the staging and follow-up of chronic liver disease. Because no reliable…”
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Matrix metalloproteinases. A review by Emonard, H, Grimaud, J A

“…Matrix metalloproteinases constitute the major proteolytic enzyme group degrading the extracellular matrix components. They are involved in the remodeling of…”
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Characterization of fat-storing cell lines derived from normal and CCl4-cirrhotic livers. Differences in the production of interleukin-6 by Greenwel, P, Schwartz, M, Rosas, M, Peyrol, S, Grimaud, J A, Rojkind, M

“…Liver fat-storing cells (FSC) play an important role in collagen deposition. During the induction of liver cirrhosis, FSC lose their fat droplets, acquire an…”
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Molecular organization of the interferon gamma-binding domain in heparan sulphate by Lortat-Jacob, H, Turnbull, J E, Grimaud, J A

“…Interferon (IFN)-gamma, in common with a number of cytokines or growth factors, strongly interacts with heparan sulphate (HS). It has been shown previously…”
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Mechanism of collagen network stabilization in human irreversible granulomatous liver fibrosis by Ricard-Blum, S, Bresson-Hadni, S, Guerret, S, Grenard, P, Volle, PJ, Risteli, L, Grimaud, JA, Vuitton, DA

“…BACKGROUND & AIMS: Cross-linking participates in the increased stability of collagen towards proteolytic degradation. Liver collagen cross-linking by…”
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High-affinity binding of interferon-γ to a basement membrane complex (matrigel) by LORTAT-JACOB, H, KLEINMAN, H. K, GRIMAUD, J.-A

“…Recently it was demonstrated that growth factors are bound to the extracellular matrix, and can regulate cell behavior. Using three different types of binding…”
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Tumor cell surface-associated binding site for the M(r) 72,000 type IV collagenase by Emonard, H P, Remacle, A G, Noël, A C, Grimaud, J A, Stetler-Stevenson, W G, Foidart, J M

“…We have studied the capacity of two human breast adenocarcinoma cells, MDA-MB231 and MCF-7, to bind exogenous M(r) 72,000 type IV collagenase by both…”
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Interferon-γ binds to heparan sulfate by a cluster of amino acids located in the C-terminal part of the molecule by Lortat-Jacob, Hugues, Grimaud, Jean-Alexis

“…Using three different approaches (domain mapping with monoclonal antibodies, limited enzymatic digestion and competition with synthetic peptides), we…”
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Long-term cultured CD40-activated B lymphocytes differentiate into plasma cells in response to IL-10 but not IL-4 by Rousset, F, Peyrol, S, Garcia, E, Vezzio, N, Andujar, M, Grimaud, J A, Banchereau, J

“…We compared the effects of IL-10 and IL-4 on the functions of B lymphocytes triggered through their CD40. During the initial phase, IL-10 was as potent as IL-4…”
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Lobular — but not periovular — inhibition of collagen deposition in the liver of S. Mansoni infected mice using interferon-γ by Lortat-Jacob, Hugues, Baltzer, Frederic, Desmoulière, Alexis, Peyrol, Simone, Grimaud, Jean-Alexis

“…Background/Aims: Interferon-γ (IFNγ) elicits antiproliferative and antifibrogenic activity in a variety of mesenchymal cells, including hepatic stellate cells…”
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Raising the social yield of research: challenge facing biotechnology by Grimaud, J A

“…The biological revolution is the latest in a series of scientific revolutions that have ushered in a new era in physics, chemistry, industry, and composite…”
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Long-term administration of interferon-α in non-responder patients with chronic hepatitis C: follow-up of liver fibrosis over 5 years by Guerret, S., Desmoulière, A., Chossegros, P., Costa, A. M. A., Badid, C., Trépo, C., Grimaud, J. A., Chevallier, M.

“…In chronic hepatitis C, previous data have shown that short‐term treatment with interferon‐α (IFN‐α) can reduce collagen deposition in the liver independently…”
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HUMAN INTERLEUKIN 4 IS A GLYCOSAMINOGLYCAN-BINDING PROTEIN by Lortat-Jacob, Hugues, Garrone, Pierre, Banchereau, Jaques, Grimaud, Jean-Alexis

“…Using different assays we examined the interaction of the cytokine interleukin 4 (IL-4) with basement membrane. Equilibrium binding analysis revealed a…”
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Transient expression of lysyl oxidase by liver myofibroblasts in murine schistosomiasis by Sommer, P, Gleyzal, C, Raccurt, M, Delbourg, M, Serrar, M, Joazeiro, P, Peyrol, S, Kagan, H, Trackman, P C, Grimaud, J A

“…Murine schistosomiasis provides an experimental model of reversible fibrosis. The lysyl oxidase catalyzes the first step of collagen and elastin enzymatic…”
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Induction of a putative laminin-binding protein of Streptococcus gordonii in human infective endocarditis by SOMMER, P, GLEYZAL, C, GUERRET, S, ETIENNE, J, GRIMAUD, J.-A

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Interferon-gamma C-terminal function: new working hypothesis. Heparan sulfate and heparin, new targets for IFN-gamma, protect, relax the cytokine and regulate its activity by Lortat-Jacob, H, Grimaud, J A

“…Structure and function of the interferon-gamma C-terminal extremity has been widely studied. A basic amino acid cluster located in this domain is involved in…”
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Pyridinoline, a mature collagen cross-link, in fibrotic livers from Schistosoma mansoni-infected mice by Ricard-Blum, S, Ville, G, Grimaud, J A

“…The amount of pyridinoline, a cross-linking amino acid found in mature collagen, was measured in murine liver for a period of up to 40 weeks following…”
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Morphology of chronic collagen resorption. A study on the late stages of schistosomal granuloma involution by Andrade, ZA, Grimaud, JA

“…Hepatic periovular schistosomal granulomas produced in mice with 50 cercariae per 10 weeks of infection were seen to involute following curative treatment of…”
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