Search Results - "GRILL, Harvey J"

A Role for GLP-1 in Treating Hyperphagia and Obesity by Grill, Harvey J

“…Abstract Obesity is a chronic recurring disease whose prevalence has almost tripled over the past 40 years. In individuals with obesity, there is significant…”
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Hindbrain Neurons as an Essential Hub in the Neuroanatomically Distributed Control of Energy Balance by Grill, Harvey J., Hayes, Matthew R.

“…This Review highlights the processing and integration performed by hindbrain nuclei, focusing on the inputs received by nucleus tractus solitarius (NTS)…”
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Hippocampus Contributions to Food Intake Control: Mnemonic, Neuroanatomical, and Endocrine Mechanisms by Kanoski, Scott E, Grill, Harvey J

“…Abstract Food intake is a complex behavior that can occur or cease to occur for a multitude of reasons. Decisions about where, when, what, and how much to eat…”
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Ghrelin Signaling in the Ventral Hippocampus Stimulates Learned and Motivational Aspects of Feeding via PI3K-Akt Signaling by Kanoski, Scott E, Fortin, Samantha M, Ricks, Katie M, Grill, Harvey J

“…Background The stomach-derived hormone ghrelin drives higher-order feeding processes related to food reward and food seeking via central nervous system…”
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GIP Receptor Agonism Attenuates GLP-1 Receptor Agonist-Induced Nausea and Emesis in Preclinical Models by Borner, Tito, Geisler, Caroline E, Fortin, Samantha M, Cosgrove, Richard, Alsina-Fernandez, Jorge, Dogra, Mridula, Doebley, Sarah, Sanchez-Navarro, Marcos J, Leon, Rosa M, Gaisinsky, Jane, White, Arianna, Bamezai, Ankur, Ghidewon, Misgana Y, Grill, Harvey J, Crist, Richard C, Reiner, Benjamin C, Ai, Minrong, Samms, Ricardo J, De Jonghe, Bart C, Hayes, Matthew R

“…Glucagon-like peptide 1 receptor (GLP-1R) agonists decrease body weight and improve glycemic control in obesity and diabetes. Patient compliance and maximal…”
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Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1 Receptor Agonists, Liraglutide and Exendin-4 by Kanoski, Scott E, Fortin, Samantha M, Arnold, Myrtha, Grill, Harvey J, Hayes, Matthew R

“…The long-acting glucagon-like peptide-1 receptor (GLP-1R) agonists, exendin-4 and liraglutide, suppress food intake and body weight. The mediating site(s) of…”
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GDF15 Induces an Aversive Visceral Malaise State that Drives Anorexia and Weight Loss by Borner, Tito, Wald, Hallie S., Ghidewon, Misgana Y., Zhang, Bei, Wu, Zhidan, De Jonghe, Bart C., Breen, Danna, Grill, Harvey J.

“…The anorectic and weight-suppressive effects of growth differentiation factor-15 (GDF15) are attracting considerable attention for treating obesity. Current…”
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Ghrelin Signaling Affects Feeding Behavior, Metabolism, and Memory through the Vagus Nerve by Davis, Elizabeth A., Wald, Hallie S., Suarez, Andrea N., Zubcevic, Jasenka, Liu, Clarissa M., Cortella, Alyssa M., Kamitakahara, Anna K., Polson, Jaimie W., Arnold, Myrtha, Grill, Harvey J., de Lartigue, Guillaume, Kanoski, Scott E.

“…Vagal afferent neuron (VAN) signaling sends information from the gut to the brain and is fundamental in the control of feeding behavior and metabolism [1]…”
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Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation by Hayes, Matthew R., Leichner, Theresa M., Zhao, Shiru, Lee, Grace S., Chowansky, Amy, Zimmer, Derek, De Jonghe, Bart C., Kanoski, Scott E., Grill, Harvey J., Bence, Kendra K.

“…Glucagon-like peptide-1 receptor (GLP-1R) activation within the nucleus tractus solitarius (NTS) suppresses food intake and body weight (BW), but the…”
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Medial nucleus tractus solitarius oxytocin receptor signaling and food intake control: the role of gastrointestinal satiation signal processing by Ong, Zhi Yi, Alhadeff, Amber L, Grill, Harvey J

“…Central oxytocin (OT) administration reduces food intake and its effects are mediated, in part, by hindbrain oxytocin receptor (OT-R) signaling. The neural…”
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Effects of Endogenous Oxytocin Receptor Signaling in Nucleus Tractus Solitarius on Satiation-Mediated Feeding and Thermogenic Control in Male Rats by Ong, Zhi Yi, Bongiorno, Diana M., Hernando, Mary Ann, Grill, Harvey J

“…Central oxytocin receptor (OT-R) signaling reduces food intake and increases energy expenditure, but the central sites and mechanisms mediating these effects…”
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Caudal Brainstem Processing Is Sufficient for Behavioral, Sympathetic, and Parasympathetic Responses Driven by Peripheral and Hindbrain Glucagon-Like-Peptide-1 Receptor Stimulation by Hayes, Matthew R, Skibicka, Karolina P, Grill, Harvey J

“…The effects of peripheral glucagon like peptide-1 receptor (GLP-1R) stimulation on feeding, gastric emptying, and energetic responses involve vagal…”
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Hypothalamic and Hindbrain Melanocortin Receptors Contribute to the Feeding, Thermogenic, and Cardiovascular Action of Melanocortins by Skibicka, Karolina P, Grill, Harvey J

“…Forebrain ventricular delivery of melanocortin receptor (MC3/4R) agonist increases energy expenditure and decreases food intake (FI). Because forebrain…”
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Protein-tyrosine Phosphatase 1B (PTP1B) Is a Novel Regulator of Central Brain-derived Neurotrophic Factor and Tropomyosin Receptor Kinase B (TrkB) Signaling by Ozek, Ceren, Kanoski, Scott E., Zhang, Zhong-Yin, Grill, Harvey J., Bence, Kendra K.

“…Neuronal protein-tyrosine phosphatase 1B (PTP1B) deficiency in mice results in enhanced leptin signaling and protection from diet-induced obesity; however,…”
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Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation by Hayes, Matthew R., Skibicka, Karolina P., Leichner, Theresa M., Guarnieri, Douglas J., DiLeone, Ralph J., Bence, Kendra K., Grill, Harvey J.

“…Medial nucleus tractus solitarius (mNTS) neurons express leptin receptors (LepRs), and intra-mNTS delivery of leptin reduces food intake and body weight. Here,…”
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Hippocampal Leptin Signaling Reduces Food Intake and Modulates Food-Related Memory Processing by KANOSKI, Scott E, HAYES, Matthew R, GREENWALD, Holly S, FORTIN, Samantha M, GIANESSI, Carol A, GILBERT, Jennifer R, GRILL, Harvey J

“…The increase in obesity prevalence highlights the need for a more comprehensive understanding of the neural systems controlling food intake; one that extends…”
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Excitatory Hindbrain-Forebrain Communication Is Required for Cisplatin-Induced Anorexia and Weight Loss by Alhadeff, Amber L, Holland, Ruby A, Zheng, Huiyuan, Rinaman, Linda, Grill, Harvey J, De Jonghe, Bart C

“…Cisplatin chemotherapy is commonly used to treat cancer despite severe energy balance side effects. In rats, cisplatin activates nucleus tractus solitarius…”
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Comparative Effects of the Long-Acting GLP-1 Receptor Ligands, Liraglutide and Exendin-4, on Food Intake and Body Weight Suppression in Rats by Hayes, Matthew R., Kanoski, Scott E., Alhadeff, Amber L., Grill, Harvey J.

“…The glucagon‐like‐peptide‐1 receptor (GLP‐1R) agonists, liraglutide (Victoza) and the synthetic product of exendin‐4 (Byetta), are approved for type II…”
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Parabrachial Interleukin-6 Reduces Body Weight and Food Intake and Increases Thermogenesis to Regulate Energy Metabolism by Mishra, Devesh, Richard, Jennifer E., Maric, Ivana, Porteiro, Begona, Häring, Martin, Kooijman, Sander, Musovic, Saliha, Eerola, Kim, López-Ferreras, Lorena, Peris, Eduard, Grycel, Katarzyna, Shevchouk, Olesya T., Micallef, Peter, Olofsson, Charlotta S., Wernstedt Asterholm, Ingrid, Grill, Harvey J., Nogueiras, Ruben, Skibicka, Karolina P.

“…Chronic low-grade inflammation and increased serum levels of the cytokine IL-6 accompany obesity. For brain-produced IL-6, the mechanisms by which it controls…”
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Hindbrain Leptin Stimulation Induces Anorexia and Hyperthermia Mediated by Hindbrain Melanocortin Receptors by Skibicka, Karolina P, Grill, Harvey J

“…Of the central nervous system receptors that could mediate the energy balance effects of leptin, those of the hypothalamic arcuate nucleus receive the greatest…”
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