Search Results - "GRIFFITHS, Lyn R."

Advances in genetics of migraine by Sutherland, Heidi G., Albury, Cassie L., Griffiths, Lyn R.

“…Background Migraine is a complex neurovascular disorder with a strong genetic component. There are rare monogenic forms of migraine, as well as more common…”
Get full text

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA by Tan, An S., Baty, James W., Dong, Lan-Feng, Bezawork-Geleta, Ayenachew, Endaya, Berwini, Goodwin, Jacob, Bajzikova, Martina, Kovarova, Jaromira, Peterka, Martin, Yan, Bing, Pesdar, Elham Alizadeh, Sobol, Margarita, Filimonenko, Anatolyj, Stuart, Shani, Vondrusova, Magdalena, Kluckova, Katarina, Sachaphibulkij, Karishma, Rohlena, Jakub, Hozak, Pavel, Truksa, Jaroslav, Eccles, David, Haupt, Larisa M., Griffiths, Lyn R., Neuzil, Jiri, Berridge, Michael V.

“…We report that tumor cells without mitochondrial DNA (mtDNA) show delayed tumor growth, and that tumor formation is associated with acquisition of mtDNA from…”
Get full text

The impact of APOA5, APOB, APOC3 and ABCA1 gene polymorphisms on ischemic stroke: Evidence from a meta-analysis by Au, Anthony, Griffiths, Lyn R., Irene, Looi, Kooi, Cheah Wee, Wei, Loo Keat

“…Genetic studies have been reported on the association between APOA5, APOB, APOC3 and ABCA1 gene polymorphisms and ischemic stroke, but results remain…”
Get full text

Next Generation Sequencing Methods for Diagnosis of Epilepsy Syndromes by Dunn, Paul, Albury, Cassie L, Maksemous, Neven, Benton, Miles C, Sutherland, Heidi G, Smith, Robert A, Haupt, Larisa M, Griffiths, Lyn R

“…Epilepsy is a neurological disorder characterized by an increased predisposition for seizures. Although this definition suggests that it is a single disorder,…”
Get full text

Human Mesenchymal Stem Cells Retain Multilineage Differentiation Capacity Including Neural Marker Expression after Extended In Vitro Expansion by Okolicsanyi, Rachel K, Camilleri, Emily T, Oikari, Lotta E, Yu, Chieh, Cool, Simon M, van Wijnen, Andre J, Griffiths, Lyn R, Haupt, Larisa M

“…The suitability of human mesenchymal stem cells (hMSCs) in regenerative medicine relies on retention of their proliferative expansion potential in conjunction…”
Get full text

Evaluation of a 7-Gene Genetic Profile for Athletic Endurance Phenotype in Ironman Championship Triathletes by Grealy, Rebecca, Herruer, Jasper, Smith, Carl L E, Hiller, Doug, Haseler, Luke J, Griffiths, Lyn R

“…Polygenic profiling has been proposed for elite endurance performance, using an additive model determining the proportion of optimal alleles in endurance…”
Get full text

A causal role for TRESK loss of function in migraine mechanisms by Pettingill, Philippa, Weir, Greg A, Wei, Tina, Wu, Yukyee, Flower, Grace, Lalic, Tatjana, Handel, Adam, Duggal, Galbha, Chintawar, Satyan, Cheung, Jonathan, Arunasalam, Kanisa, Couper, Elizabeth, Haupt, Larisa M, Griffiths, Lyn R, Bassett, Andrew, Cowley, Sally A, Cader, M Zameel

“…The two-pore potassium channel, TRESK has been implicated in nociception and pain disorders. We have for the first time investigated TRESK function in human…”
Get full text

Can Genetic Markers Predict the Sporadic Form of Alzheimer’s Disease? An Updated Review on Genetic Peripheral Markers by Theron, Danelda, Hopkins, Lloyd N, Sutherland, Heidi G, Griffiths, Lyn R, Fernandez, Francesca

“…Alzheimer’s disease (AD) is the most common form of dementia that affects millions of individuals worldwide. Although the research over the last decades has…”
Get full text

Review: Alternative Splicing (AS) of Genes As An Approach for Generating Protein Complexity by Roy, Bishakha, Haupt, Larisa M, Griffiths, Lyn R

“…Prior to the completion of the human genome project, the human genome was thought to have a greater number of genes as it seemed structurally and functionally…”
Get full text

Exploiting Heparan Sulfate Proteoglycans in Human Neurogenesis-Controlling Lineage Specification and Fate by Yu, Chieh, Griffiths, Lyn R, Haupt, Larisa M

“…Unspecialized, self-renewing stem cells have extraordinary application to regenerative medicine due to their multilineage differentiation potential. Stem cell…”
Get full text

Genome-wide association study reveals three susceptibility loci for common migraine in the general population by Schürks, Markus, Kurth, Tobias, Chasman, Daniel I, Anttila, Verneri, de Vries, Boukje, Schminke, Ulf, Launer, Lenore J, Terwindt, Gisela M, van den Maagdenberg, Arn M J M, Fendrich, Konstanze, Völzke, Henry, Ernst, Florian, Griffiths, Lyn R, Buring, Julie E, Kallela, Mikko, Freilinger, Tobias, Kubisch, Christian, Ridker, Paul M, Palotie, Aarno, Ferrari, Michel D, Hoffmann, Wolfgang, Zee, Robert Y L

“…Migraine is a common, heterogeneous and heritable neurological disorder. Its pathophysiology is incompletely understood, and its genetic influences at the…”
Get full text

Exonic mutations in cell–cell adhesion may contribute to CADASIL-related CSVD pathology by Dunn, Paul J., Lea, Rodney A., Maksemous, Neven, Smith, Robert A., Sutherland, Heidi G., Haupt, Larisa M., Griffiths, Lyn R.

“…Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a condition caused by mutations in NOTCH3 and results…”
Get full text

The gene SMART study: method, study design, and preliminary findings by Yan, Xu, Eynon, Nir, Papadimitriou, Ioannis D, Kuang, Jujiao, Munson, Fiona, Tirosh, Oren, O'Keefe, Lannie, Griffiths, Lyn R, Ashton, Kevin J, Byrne, Nuala, Pitsiladis, Yannis P, Bishop, David J

“…The gene SMART (genes and the Skeletal Muscle Adaptive Response to Training) Study aims to identify genetic variants that predict the response to both a single…”
Get full text

The effects of OPRM1 118A>G on methadone response in pain management in advanced cancer at end of life by Haupt, Larisa M., Haywood, Alison, Sutherland, Heidi G., Yu, Chieh, Albury, Cassie L., Pharasi, Anushka, Zunk, Mathew, George, Rani, Griffiths, Lyn R., Good, Phillip, Hardy, Janet

“…Cancer pain is the most feared symptom at end of life. Methadone has advantages over other opioids but is associated with significant variability in clinical…”
Get full text

Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity by Adewuyi, Emmanuel O, Sapkota, Yadav, International Endogene Consortium Iec, andMe Research Team, International Headache Genetics Consortium Ihgc, Auta, Asa, Yoshihara, Kosuke, Nyegaard, Mette, Griffiths, Lyn R, Montgomery, Grant W, Chasman, Daniel I, Nyholt, Dale R

“…Observational epidemiological studies indicate that endometriosis and migraine co-occur within individuals more than expected by chance. However, the aetiology…”
Get full text

Associations between Cerebrovascular Function and the Expression of Genes Related to Endothelial Function in Hormonal Migraine by Dzator, Jemima S A, Smith, Robert A, Coupland, Kirsten G, Howe, Peter R C, Griffiths, Lyn R

“…There is evidence to suggest that hormonal migraine is associated with altered cerebrovascular function. We aimed to investigate whether the expression of…”
Get full text

GSTM1 and GSTT1 polymorphisms associated with pain in a chemotherapy-induced peripheral neuropathy cohort by Dunn, Paul J., Griffiths, Lyn R., Yates, Patsy, Haupt, Larisa M., Alexander, Kim E.

“…Purpose Chemotherapy induced peripheral neuropathy (CIPN) is a debilitating condition that is a direct consequence of receiving cancer treatment. The molecular…”
Get full text

Association of KCNJ6 rs2070995 and methadone response for pain management in advanced cancer at end-of-life by Ozberk, Deniz, Haywood, Alison, Sutherland, Heidi G., Yu, Chieh, Albury, Cassie L., Zunk, Mathew, George, Rani, Good, Phillip, Griffiths, Lyn R., Hardy, Janet, Haupt, Larisa M.

“…Opioids are the therapeutic agents of choice to manage moderate to severe pain in patients with advanced cancer, however the unpredictable inter-individual…”
Get full text

An epigenetic clock for human skeletal muscle by Voisin, Sarah, Harvey, Nicholas R., Haupt, Larisa M., Griffiths, Lyn R., Ashton, Kevin J., Coffey, Vernon G., Doering, Thomas M., Thompson, Jamie‐Lee M., Benedict, Christian, Cedernaes, Jonathan, Lindholm, Malene E., Craig, Jeffrey M., Rowlands, David S., Sharples, Adam P., Horvath, Steve, Eynon, Nir

“…Background Ageing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA…”
Get full text

Saliva as a comparable-quality source of DNA for Whole Exome Sequencing on Ion platforms by Ibrahim, Omar, Sutherland, Heidi G., Haupt, Larisa M., Griffiths, Lyn R.

“…Whole Exome Sequencing (WES) utilises overlapping fragments prone to sequencing artefacts. Saliva, a non-invasive source of DNA, has been successfully used in…”
Get full text