Search Results - "GRIFFITH, Jeffrey K"

Tumor necrosis factor alpha induces Warburg‐like metabolism and is reversed by anti‐inflammatory curcumin in breast epithelial cells by Vaughan, Roger A., Garcia‐Smith, Randi, Dorsey, Jonathan, Griffith, Jeffrey K., Bisoffi, Marco, Trujillo, Kristina A.

“…The reprogramming of cellular metabolism in cancer cells is a well‐documented effect. It has previously been shown that common oncogene expression can induce…”
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Mammary field cancerization: molecular evidence and clinical importance by Heaphy, Christopher M, Griffith, Jeffrey K, Bisoffi, Marco

“…The term “field cancerization” originally denoted the presence of histologically abnormal tissue/cells surrounding primary tumors of the head and neck. Similar…”
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Telomere DNA content and allelic imbalance demonstrate field cancerization in histologically normal tissue adjacent to breast tumors by Heaphy, Christopher M., Bisoffi, Marco, Fordyce, Colleen A., Haaland, Christina M., Hines, William C., Joste, Nancy E., Griffith, Jeffrey K.

“…Cancer arises from an accumulation of mutations that promote the selection of cells with progressively malignant phenotypes. Previous studies have shown that…”
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Telomere DNA Content Predicts Breast Cancer–Free Survival Interval by HEAPHY, Christopher M, BAUMGARTNER, Kathy B, BISOFFI, Marco, BAUMGARTNER, Richard N, GRIFFITH, Jeffrey K

“…Background: Telomeres are nucleoprotein complexes that protect chromosome ends from degradation and recombination. Critically shortened telomeres generate…”
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Markers of Field Cancerization: Proposed Clinical Applications in Prostate Biopsies by Bisoffi, Marco, Griffith, Jeffrey K., Jones, Anna C., Trujillo, Kristina A.

“…Field cancerization denotes the occurrence of genetic, epigenetic, and biochemical aberrations in structurally intact cells in histologically normal tissues…”
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Coordinate regulation between expression levels of telomere‐binding proteins and telomere length in breast carcinomas by Butler, Kimberly S., Hines, William C., Heaphy, Christopher M., Griffith, Jeffrey K.

“…Telomere dysregulation occurs in both the in situ and invasive stages of many carcinomas, including breast. Knockout experiments have identified several…”
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Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naïve patients with depression by Garcia-Rizo, Clemente, Fernandez-Egea, Emilio, Miller, Brian J, Oliveira, Cristina, Justicia, Azucena, Griffith, Jeffrey K, Heaphy, Christopher M, Bernardo, Miguel, Kirkpatrick, Brian

“…Highlight ► First article describing senescence, metabolic and immune abnormalities in naïve patients with depression suggesting an accelerated aging state…”
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Telomeres: Prognostic markers for solid tumors by Bisoffi, Marco, Heaphy, Christopher M., Griffith, Jeffrey K.

“…Solid tumors continue to affect millions of people worldwide. Increasingly sophisticated diagnostic tools contribute to the high incidence rates for some tumor…”
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Quantitative and Spatial Measurements of Telomerase Reverse Transcriptase Expression within Normal and Malignant Human Breast Tissues by Hines, William C, Fajardo, Alexandra M, Joste, Nancy E, Bisoffi, Marco, Griffith, Jeffrey K

“…The enzyme telomerase catalyzes the de novo synthesis of telomere repeats, thereby maintaining telomere length, which is necessary for unlimited cellular…”
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Markers of fibrosis and epithelial to mesenchymal transition demonstrate field cancerization in histologically normal tissue adjacent to breast tumors by Trujillo, Kristina A., Heaphy, Christopher M., Mai, Minh, Vargas, Keith M., Jones, Anna C., Vo, Phung, Butler, Kimberly S., Joste, Nancy E., Bisoffi, Marco, Griffith, Jeffrey K

“…Previous studies have shown that a field of genetically altered but histologically normal tissue extends 1 cm or more from the margins of human breast tumors…”
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Telomere Length and Pulse Pressure in Newly Diagnosed, Antipsychotic-Naive Patients With Nonaffective Psychosis by Fernandez-Egea, Emilio, Bernardo, Miguel, Heaphy, Christopher M., Griffith, Jeffrey K., Parellada, Eduard, Esmatjes, Enric, Conget, Ignacio, Nguyen, Linh, George, Varghese, Stöppler, Hubert, Kirkpatrick, Brian

“…Introduction: Recent studies suggest that in addition to factors such as treatment side effects, suicide, and poor health habits, people with schizophrenia may…”
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Protease nexin-1 expression is altered in human breast cancer by Candia, Britny J, Hines, William C, Heaphy, Christopher M, Griffith, Jeffrey K, Orlando, Robert A

“…Urokinase-type Plasminogen Activator (uPA), a serine protease, plays a pivotal role in human breast cancer metastasis by mediating the degradation of…”
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The clinical significance of inflammatory cytokines in primary cell culture in endometrial carcinoma by Smith, Harriet O., Stephens, Nicole D., Qualls, Clifford R., Fligelman, Tal, Wang, Tao, Lin, Chang-Yun, Burton, Elizabeth, Griffith, Jeffrey K., Pollard, Jeffrey W.

“…Endometrial cancer is the most common malignancy of the female genital tract, and the incidence and mortality rates from this disease are increasing. Although…”
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Chemiluminescent measurement of telomere DNA content in biopsies by Fordyce, Colleen A, Heaphy, Christopher M, Griffith, Jeffrey K

“…Telomeres are nucleoprotein complexes that protect the ends of chromosomes from fusion and degradation. They are typically shorter in tumor cells than in…”
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Breast field cancerization: isolation and comparison of telomerase-expressing cells in tumor and tumor adjacent, histologically normal breast tissue by Trujillo, Kristina A, Hines, William C, Vargas, Keith M, Jones, Anna C, Joste, Nancy E, Bisoffi, Marco, Griffith, Jeffrey K

“…Telomerase stabilizes chromosomes by maintaining telomere length, immortalizes mammalian cells, and is expressed in more than 90% of human tumors. However, the…”
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Measurement of telomeric DNA content in human tissues by Bryant, J E, Hutchings, K G, Moyzis, R K, Griffith, J K

“…Telomeres, nucleoprotein complexes at the ends of eukaryotic chromosomes, are 10-12 kbp in length in somatic cells, but as small as 1-2 kbp in rapidly growing…”
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Telomere DNA Content in Prostate Biopsies Predicts Early Rise in Prostate-specific Antigen After Radical Prostatectomy for Prostate Cancer by Treat, Eric G, Heaphy, Christopher M, Massie, Larry W, Bisoffi, Marco, Smith, Anthony Y, Davis, Michael S, Griffith, Jeffrey K

“…Objective To determine whether measurement of telomere DNA content (TC) in prostate biopsy tissue predicts prostrate-specific antigen (PSA) recurrence in men…”
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Early growth response 1 and fatty acid synthase expression is altered in tumor adjacent prostate tissue and indicates field cancerization by Jones, Anna C., Trujillo, Kristina A., Phillips, Genevieve K., Fleet, Trisha M., Murton, Jaclyn K., Severns, Virginia, Shah, Satyan K., Davis, Michael S., Smith, Anthony Y., Griffith, Jeffrey K., Fischer, Edgar G., Bisoffi, Marco

“…BACKGROUND Field cancerization denotes the occurrence of molecular alterations in histologically normal tissues adjacent to tumors. In prostate cancer,…”
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Telomere content correlates with stage and prognosis in breast cancer by FORDYCE, Colleen A, HEAPHY, Christopher M, BISOFFI, Marco, WYACO, Jessica L, JOSTE, Nancy E, MANGALIK, Aroop, BAUMGARTNER, Kathy B, BAUMGARTNER, Richard N, HUNT, William C, GRIFFITH, Jeffrey K

“…To evaluate the hypothesis that telomere DNA content (TC) in breast tumor tissue correlates with TNM staging and prognosis. Slot blot assay was used to…”
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Organ-wide telomeric status in diseased and disease-free prostatic tissues by Heaphy, Christopher M., Fleet, Trisha M., Treat, Eric G., Lee, Sang-Joon, Smith, Anthony Y., Davis, Michael S., Griffith, Jeffrey K., Fischer, Edgar G., Bisoffi, Marco

“…Background Telomere attrition occurs early in the development of prostatic adenocarcinoma. However, little is known about either telomere status in benign…”
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