Search Results - "GRIFFIN, Graeme"

Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition by THOMSON, Stuart, BUCK, Elizabeth, PETTI, Filippo, GRIFFIN, Graeme, BROWN, Eric, RAMNARINE, Nishal, IWATA, Kenneth K, GIBSON, Neil, HALEY, John D

“…Treatment of second- and third-line patients with non-small-cell lung carcinoma (NSCLC) with the epidermal growth factor receptor (EGFR) kinase inhibitor…”
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Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents by Overton, Hilary A., Babbs, Adam J., Doel, Sheila M., Fyfe, Matthew C.T., Gardner, Lisa S., Griffin, Graeme, Jackson, Helen C., Procter, Martin J., Rasamison, Chrystelle M., Tang-Christensen, Mads, Widdowson, Peter S., Williams, Geoffery M., Reynet, Christine

“…The endogenous lipid signaling agent oleoylethanolamide (OEA) has recently been described as a peripherally acting agent that reduces food intake and body…”
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Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non–small-cell lung, pancreatic, colon, and breast tumors by Buck, Elizabeth, Eyzaguirre, Alexandra, Brown, Eric, Petti, Filippo, McCormack, Siobhan, Haley, John D, Iwata, Kenneth K, Gibson, Neil W, Griffin, Graeme

“…The receptor for epidermal growth factor (EGFR) is overexpressed in many cancers. One important signaling pathway regulated by EGFR is the phosphatidylinositol…”
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Evidence for a new G protein-coupled cannabinoid receptor in mouse brain by Breivogel, C S, Griffin, G, Di Marzo, V, Martin, B R

“…The purpose of these studies was to support the hypothesis that an undiscovered cannabinoid receptor exists in brain. [(35)S]GTP gamma S binding was stimulated…”
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Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo by Lichtman, Aron H, Hawkins, E Gregory, Griffin, Graeme, Cravatt, Benjamin F

“…Fatty acid amides (FAAs) represent a class of neuromodulatory lipids that includes the endocannabinoid anandamide and the sleep-inducing substance oleamide…”
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Phosphotyrosine Signaling Networks in Epidermal Growth Factor Receptor Overexpressing Squamous Carcinoma Cells by Thelemann, April, Petti, Filippo, Griffin, Graeme, Iwata, Ken, Hunt, Tony, Settinari, Tina, Fenyo, David, Gibson, Neil, Haley, John D

“…Overexpression and enhanced activation of the epidermal growth factor (EGF) receptor are frequent events in human cancers that correlate with poor prognosis…”
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Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding by MIE MIE AUNG, GRIFFIN, G, HUFFMAN, J. W, WU, M.-J, KEEL, C, YANG, B, SHOWALTER, V. M, ABOOD, M. E, MARTIN, B. R

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Cannabinoid receptors can activate and inhibit G protein-coupled inwardly rectifying potassium channels in a xenopus oocyte expression system by McAllister, S D, Griffin, G, Satin, L S, Abood, M E

“…In this study, we focused on the pharmacological characterization of cannabinoid receptor coupling to G protein-gated inwardly rectifying potassium (GIRK)…”
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A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid by Di Marzo, Vincenzo, Griffin, Graeme, De Petrocellis, Luciano, Brandi, Ines, Bisogno, Tiziana, Williams, William, Grier, Mark C, Kulasegram, Sanjitha, Mahadevan, Anu, Razdan, Raj K, Martin, Billy R

“…Arvanil, a structural "hybrid" between the endogenous cannabinoid CB1 receptor ligand anandamide and capsaicin, is a potent agonist for the capsaicin receptor…”
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(R)-Methanandamide: A Chiral Novel Anandamide Possessing Higher Potency and Metabolic Stability by Abadji, Vasiliki, Lin, Sonyuan, Taha, Gihan, Griffin, Graeme, Stevenson, Lesley A, Pertwee, Roger G, Makriyannis, Alexandros

“…Four chiral congeners of arachidonylethanolamide (anandamide) have been synthesized and evaluated for (a) their ability to bind to the cannabinoid receptor in…”
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Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals by GRIFFIN, G, FERNANDO, S. R, ROSS, R. A, MCKAY, N. G, ASHFORD, M. L. J, SHIRE, D, HUFFMAN, J. W, YU, S, LAINTON, J. A. H, PERTWEE, R. G

“…We have investigated whether there are cannabinoid CB2 receptors that can mediate cannabinoid-induced inhibition of electrically evoked contractions in the…”
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Effects of two endogenous fatty acid ethanolamides on mouse vasa deferentia by Pertwee, R, Griffin, G, Hanus, L, Mechoulam, R

“…Anandamide (20:3, n - 6) (homo-gamma-linolenylethanolamide) and anandamide (22:4, n - 6) (7,10,13,16-docosatetraenylethanolamide) are known to be present in…”
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SR-141716A-induced stimulation of locomotor activity by Bass, Caroline E, Griffin, Graeme, Grier, Mark, Mahadevan, Anu, Razdan, Raj K, Martin, Billy R

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Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors by Mechoulam, Raphael, Ben-Shabat, Shimon, Hanus, Lumir, Ligumsky, Moshe, Kaminski, Norbert E., Schatz, Anthony R., Gopher, Asher, Almog, Shlomo, Martin, Billy R., Compton, David R., Pertwee, Roger G., Griffin, Graeme, Bayewitch, Michael, Barg, Jacob, Vogel, Zvi

“…In this study, we report the isolation from canine intestines of 2-arachidonyl glycerol (2-Ara-Gl). Its structure was determined by mass spectrometry and by…”
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Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor by Devane, William A., Hanuš, Lumir, Breuer, Aviva, Pertwee, Roger G., Stevenson, Lesley A., Griffin, Graeme, Gibson, Dan, Mandelbaum, Asher, Etinger, Alexander, Mechoulam, Raphael

“…Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in a screen for endogenous ligands for the cannabinoid receptor. The…”
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Evaluation of the cannabinoid CB2 receptor-selective antagonist, SR144528: further evidence for cannabinoid CB2 receptor absence in the rat central nervous system by GRIFFIN, G, WRAY, E. J, QING TAO, MCALLISTER, S. D, RORRER, W. K, AUNG, M, MARTIN, B. R, ABOOD, M. E

“…The aim of this study was to characterize the activity of the cannabinoid CB2 receptor selective antagonist, N-[(1S)-endo-1,3,3-trimethyl bicyclo[2.2.1]…”
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SR-141716A-induced stimulation of locomotor activity: A structure–activity relationship study by Bass, Caroline E, Griffin, Graeme, Grier, Mark, Mahadevan, Anu, Razdan, Raj K, Martin, Billy R

“…The central cannabinoid receptor (CB 1) antagonist, SR-141716A, has been used extensively to ascertain that cannabinoids interact with the CB 1 receptor…”
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Evaluation of cannabinoid receptor agonists and antagonists using the guanosine-5'-O-(3-[35S]thio)-triphosphate binding assay in rat cerebellar membranes by Griffin, G, Atkinson, P J, Showalter, V M, Martin, B R, Abood, M E

“…Cannabinoid receptors are members of the superfamily of G protein-coupled receptors. Their activation has previously been shown to stimulate guanosine…”
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AM630, a competitive cannabinoid receptor antagonist by Pertwee, R, Griffin, G, Fernando, S, Li, X, Hill, A, Makriyannis, A

“…AM630 (iodopravadoline), a novel aminoalkylindole, has been found to attenuate the ability of a number of cannabinoids to inhibit electrically-evoked twitches…”
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Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations by Pertwee, Roger G., Fernando, Susanthi R., Griffin, Graeme, Abadji, Vasiliki, Makriyannis, Alexandros

“…The endogenous cannabinoid receptor ligand, anandamide, produced a concentration related inhibition of electrically evoked contractions of the guinea-pig…”
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