Search Results - "GRIFFIN, Edward F"

ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic Caenorhabditis elegans by Griffin, Edward F, Scopel, Samuel E, Stephen, Cayman A, Holzhauer, Adam C, Vaji, Madeline A, Tuckey, Ryan A, Berkowitz, Laura A, Caldwell, Kim A, Caldwell, Guy A

“…Allele-specific distinctions in the human apolipoprotein E ( ) locus represent the best-characterized genetic predictor of Alzheimer's disease (AD) risk…”
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Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1‐dependent TFEB/TFE3 regulation by van der Welle, Reini E N, Jobling, Rebekah, Burns, Christian, Sanza, Paolo, van der Beek, Jan A, Fasano, Alfonso, Chen, Lan, Zwartkruis, Fried J, Zwakenberg, Susan, Griffin, Edward F, ten Brink, Corlinda, Veenendaal, Tineke, Liv, Nalan, van Ravenswaaij‐Arts, Conny M A, Lemmink, Henny H, Pfundt, Rolph, Blaser, Susan, Sepulveda, Carolina, Lozano, Andres M, Yoon, Grace, Santiago‐Sim, Teresa, Asensio, Cedric S, Caldwell, Guy A, Caldwell, Kim A, Chitayat, David, Klumperman, Judith

“…Vacuolar protein sorting 41 (VPS41) is as part of the Homotypic fusion and Protein Sorting (HOPS) complex required for lysosomal fusion events and, independent…”
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Vacuolar protein sorting protein 41 (VPS41) at an intersection of endosomal traffic in neurodegenerative disease by Griffin, Edward, Caldwell, Kim, Caldwell, Guy

“…On the contrary, both the GTP- and GDP-locked states of arl-8 increased neurodegeneration. Because Arl8 was required for localization of Vps41 and Rab7 in…”
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Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer's and Parkinson's disease models of neurodegeneration by Griffin, Edward F, Yan, Xiaohui, Caldwell, Kim A, Caldwell, Guy A

“…Abstract Commonalities and, in some cases, pathological overlap between neurodegenerative diseases have led to speculation that targeting of underlying…”
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Genetic and Pharmacological Discovery for Alzheimer’s Disease Using Caenorhabditis elegans by Griffin, Edward F, Caldwell, Kim A, Caldwell, Guy A

“…The societal burden presented by Alzheimer’s disease warrants both innovative and expedient means by which its underlying molecular causes can be both…”
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Tobramycin-Treated Pseudomonas aeruginosa PA14 Enhances Streptococcus constellatus 7155 Biofilm Formation in a Cystic Fibrosis Model System by Price, Katherine E, Naimie, Amanda A, Griffin, Edward F, Bay, Charles, O'Toole, George A

“…Cystic fibrosis (CF) is a human genetic disorder which results in a lung environment that is highly conducive to chronic microbial infection. Over the past…”
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In vitro evaluation of tobramycin and aztreonam versus Pseudomonas aeruginosa biofilms on cystic fibrosis-derived human airway epithelial cells by QIANRU YU, GRIFFIN, Edward F, MOREAU-MARQUIS, Sophie, SCHWARTZMAN, Joseph D, STANTON, Bruce A, O'TOOLE, George A

“…Aztreonam for inhalation solution (AZLI) was recently approved by the FDA for treating cystic fibrosis (CF) patients infected with Pseudomonas aeruginosa. Here…”
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