Search Results - "GRIBBLE, Gordon W"

Biological Activity of Recently Discovered Halogenated Marine Natural Products by Gribble, Gordon W

“…This review presents the biological activity-antibacterial, antifungal, anti-parasitic, antiviral, antitumor, antiinflammatory, antioxidant, and enzymatic…”
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Trifluoromethylation of aryl and heteroaryl halides by Roy, Sudipta, Gregg, Brian T., Gribble, Gordon W., Le, Van-Duc, Roy, Sujata

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Recently Discovered Naturally Occurring Heterocyclic Organohalogen Compounds by W. Gribble, Gordon

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The diversity of naturally produced organohalogens by Gribble, Gordon W.

“…More than 3800 organohalogen compounds, mainly containing chlorine or bromine but a few with iodine and fluorine, are produced by living organisms or are…”
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The Generation of Indole-2,3-quinodimethanes from the Deamination of 1,2,3,4-Tetrahydropyrrolo[3,4- b ]indoles by Rinderspacher, Alison, Gribble, Gordon W

“…A novel generation of indole-2,3-quinodimethanes via the deamination of 1,2,3,4-tetrahydropyrrolo[s3,4- ]indoles is reported…”
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New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress by Sporn, Michael B, Liby, Karen T, Yore, Mark M, Fu, Liangfeng, Lopchuk, Justin M, Gribble, Gordon W

“…We review the original rationale for the development and the chemistry of a series of new synthetic oleanane triterpenoids (SO), based on oleanolic acid (1) as…”
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Synthesis of a Novel Disubstituted Indole by Wright, Stephen W., Gribble, Gordon W.

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Natural Organohalogens: A New Frontier for Medicinal Agents? by Gribble, Gordon W

“…More than 4000 naturally occurring organohalogen compounds are known. These include a relatively small number of abiogenic organohalogens from volcanoes,…”
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Triple Benzannulation of Naphthalene via a 1,3,6-Naphthotriyne Synthetic Equivalent. Synthesis of Dibenz[a,c]anthracene by Mannes, Philip Z, Onyango, Evans O, Gribble, Gordon W

“…A new synthesis of dibenzo­[a,c]­anthracene (4) is described that features the generation, from tetrabromo-bis-triflate 1 and phenyllithium, of a…”
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Naturally Occurring Organohalogen Compounds by Gribble, Gordon W

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Extremely Potent Triterpenoid Inducers of the Phase 2 Response: Correlations of Protection against Oxidant and Inflammatory Stress by Dinkova-Kostova, Albena T., Liby, Karen T., Stephenson, Katherine K., Holtzclaw, W. David, Gao, Xiangqun, Suh, Nanjoo, Williams, Charlotte, Risingsong, Renee, Honda, Tadashi, Gribble, Gordon W., Sporn, Michael B., Talalay, Paul

“…A series of synthetic triterpenoid (TP) analogues of oleanolic acid are powerful inhibitors of cellular inflammatory processes such as the induction by IFN-γ…”
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Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes by Yates, Melinda S, Tauchi, Masafumi, Katsuoka, Fumiki, Flanders, Kathleen C, Liby, Karen T, Honda, Tadashi, Gribble, Gordon W, Johnson, Delinda A, Johnson, Jeffrey A, Burton, Neal C, Guilarte, Tomás R, Yamamoto, Masayuki, Sporn, Michael B, Kensler, Thomas W

“…Synthetic triterpenoids have been developed, which are potent inducers of cytoprotective enzymes and inhibitors of inflammation, greatly improving on the weak…”
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A Survey of Recently Discovered Naturally Occurring Organohalogen Compounds by Gribble, Gordon W.

“…The discovery of naturally occurring organohalogen compounds has increased astronomically in the 55 years since they were first discoveredfrom fewer than 50…”
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A Short Synthesis of 9-Fluoroellipticine from 5-Fluoroindole by W. Gribble, Gordon, A. Davis, Deborah

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Synthesis of a Dicyano Abietane, a Key Intermediate for the Anti-inflammatory Agent TBE-31 by Onyango, Evans O, Fu, Liangfeng, Gribble, Gordon W

“…The synthesis of dicyano abietane 11, a potential precursor to the biologically active tricyclic bis-cyano enone 6 (TBE-31), was accomplished in eight steps…”
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A Short, Protecting Group-Free Total Synthesis of Bruceollines D, E, and J by Lopchuk, Justin M, Green, Ilene L, Badenock, Jeanese C, Gribble, Gordon W

“…A short, protecting group-free total synthesis of bruceollines D, E, and J has been achieved. The enantioselective reduction of bruceolline E with…”
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Metal-catalyzed amidation by Roy, Sudipta, Roy, Sujata, Gribble, Gordon W.

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Tricyclic Compounds Containing Nonenolizable Cyano Enones. A Novel Class of Highly Potent Anti-Inflammatory and Cytoprotective Agents by Honda, Tadashi, Yoshizawa, Hidenori, Sundararajan, Chitra, David, Emilie, Lajoie, Marc J, Favaloro, Frank G, Janosik, Tomasz, Su, Xiaobo, Honda, Yukiko, Roebuck, Bill D, Gribble, Gordon W

“…Forty-four novel tricycles containing nonenolizable cyano enones (TCEs) were designed and synthesized on the basis of a semisynthetic pentacyclic triterpenoid,…”
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The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice by LIBY, Karen, ROYCE, Darlene B, WILLIAMS, Charlotte R, RISINGSONG, Renee, YORE, Mark M, HONDA, Tadashi, GRIBBLE, Gordon W, DMITROVSKY, Ethan, SPORN, Thomas A, SPORN, Michael B

“…We report the first use of new synthetic triterpenoids to prevent lung cancer in experimental animals. Female A/J mice were treated with the mutagenic…”
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The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling by LIBY, Karen, HOCK, Thomas, GRIBBLE, Gordon W, HILL-KAPTURCZAK, Nathalie, AGARWAL, Anupam, SPORN, Michael B, YORE, Mark M, SUH, Nanjoo, PLACE, Andrew E, RISINGSONG, Renee, WILLIAMS, Charlotte R, ROYCE, Darlene B, HONDA, Tadashi, HONDA, Yukiko

“…The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) and its derivative…”
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