Search Results - "GRIBBLE, G. W"

Novel chemistry of indole in the synthesis of heterocycles by Gribble, G. W.

“…Indoles that are substituted at the 2- or 3-position with electron-withdrawing groups (nitro, phenylsulfonyl) undergo nucleophilic addition, 1,3-dipolar…”
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Synthetic Oleanane and Ursane Triterpenoids with Modified Rings A and C:  A Series of Highly Active Inhibitors of Nitric Oxide Production in Mouse Macrophages by Honda, Tadashi, Rounds, BarbieAnn V, Bore, Lothar, Finlay, Heather J, Favaloro, Frank G, Suh, Nanjoo, Wang, Yongping, Sporn, Michael B, Gribble, Gordon W

“…We have designed and synthesized 16 new olean- and urs-1-en-3-one triterpenoids with various modified rings C as potential antiinflammatory and cancer…”
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Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages by NANJOO SUH, HONDA, T, FINLAY, H. J, BARCHOWSKY, A, WILLIAMS, C, BENOIT, N. E, XIE, Q.-W, NATHAN, C, GRIBBLE, G. W, SPORN, M. B

“…We have synthesized more than 80 novel triterpenoids, all derivatives of oleanolic and ursolic acid, as potential anti-inflammatory and chemopreventive agents…”
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A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity by NANJOO SUH, YONGPING WANG, WILLIAMS, C. R, GENGFEI WU, DANNENBERG, A. J, FLANDERS, K. C, LETTERIO, J. J, MANGELSDORF, D. J, NATHAN, C. F, LANANH NGUYEN, PORTER, W. W, REN, R. F, HONDA, T, ROBERTS, A. B, ROCHE, N. S, SUBBARAMAIAH, K, SPORN, M. B, GRIBBLE, G. W, DMITROVSKY, E, HICKEY, W. F, MAUE, R. A, PLACE, A. E, PORTER, D. M, SPINELLA, M. J

“…The new synthetic oleanane triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO) is a potent, multifunctional molecule. It induces monocytic…”
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The Diversity of Natural Organochlorines in Living Organisms by Gribble, G. W.

“…Of the more than 2,600 known naturally occurring organohalogen compounds, more than 1,500 contain chlorine. These organochlorines, which range in structural…”
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The diversity of naturally produced organohalogens by Gribble, Gordon W.

“…More than 3800 organohalogen compounds, mainly containing chlorine or bromine but a few with iodine and fluorine, are produced by living organisms or are…”
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Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages by Honda, Tadashi, Rounds, BarbieAnn V., Gribble, Gordon W., Suh, Nanjoo, Wang, Yongping, Sporn, Michael B.

“…New derivatives with electron-withdrawing substituents at the C-2 position of 3-oxoolean-1-en-28-oic acid were synthesized. Among them,…”
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Novel synthetic oleanane triterpenoids: A series of highly active inhibitors of nitric oxide production in mouse macrophages by Honda, Ta-i, Rounds, BarbieAnn V., Bore, Lothar, Favaloro, Frank G., Gribble, Gordon W., Suh, Nanjoo, Wang, Yongping, Sporn, Michael B.

“…Novel oleanane triterpenoids with modified rings A and C were designed and synthesized. Among them, methyl 2-carboxy-3,12-dioxooleana-1,9-dien-28-oate showed…”
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A Synthetic Triterpenoid, 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid (CDDO), Is a Ligand for the Peroxisome Proliferator-Activated Receptor γ by Wang, Yongping, Porter, Weston W, Suh, Nanjoo, Honda, Tadashi, Gribble, Gordon W, Leesnitzer, Lisa M, Plunket, Kelli D, Mangelsdorf, David J, Blanchard, Steven G, Willson, Timothy M, Sporn, Michael B

“…A novel synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), previously reported to have potent differentiating, antiproliferative,…”
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The abundant natural sources and uses of chlorinated chemicals by Gribble, G W

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The natural production of chlorinated compounds by Gribble, Gordon W

“…Chlorinated chemicals, once thought to be produced only by human actions, are now recognized as natural products. Some of the 2,000 halogenated chemicals…”
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Bis-Suzuki reactions of 2,3-dihaloindoles. A convenient synthesis of 2,3-diarylindoles by Liu, Yanbing, Gribble, Gordon W

“…A convenient, one-pot synthesis of 2,3-diarylindoles 4 is described via a bis-Suzuki palladium-catalyzed cross coupling of 2,3-dihalo-1-(phenylsulfonyl)indoles…”
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Amazing Organohalogens by Gribble, Gordon W

“…Although best known as synthetic toxicants, thousands of compounds are, in fact, part of the natural environment. Here, Gribble discusses the nature of…”
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Design, Synthesis, and Biological Evaluation of Biotin Conjugates of 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid for the Isolation of the Protein Targets by Honda, Tadashi, Janosik, Tomasz, Honda, Yukiko, Han, Jie, Liby, Karen T, Williams, Charlotte R, Couch, Robin D, Anderson, Amy C, Sporn, Michael B, Gribble, Gordon W

“…2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO, 1) and related compounds [for example, CDDO-Me (2) and CDDO-Im (3)] are potential anti-inflammatory,…”
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Novel Synthetic Oleanane and Ursane Triterpenoids with Various Enone Functionalities in Ring A as Inhibitors of Nitric Oxide Production in Mouse Macrophages by Honda, Tadashi, Gribble, Gordon W, Suh, Nanjoo, Finlay, Heather J, Rounds, BarbieAnn V, Bore, Lothar, Favaloro, Frank G, Wang, Yongping, Sporn, Michael B

“…We initially randomly synthesized about 60 oleanane and ursane triterpenoids as potential anti-inflammatory and cancer chemopreventive agents. Preliminary…”
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Partial Synthesis of Krukovines A and B, Triterpene Ketones Isolated from the Brazilian Medicinal Plant Maytenus krukovii by Honda, Tadashi, Finlay, Heather J, Gribble, Gordon W

“…Krukovines A (1) and B (2), triterpene ketones isolated from the Brazilian medicinal plant “chuchuhuasi” (Maytenus krukovii), were synthesized in eight steps…”
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Naturally Occurring Organohalogen Compounds--A Survey by Gribble, Gordon W

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Synthesis of β-Boswellic Acid Analogues with a Carboxyl Group at C-17 Isolated from the Bark of Schefflera octophylla by BORE, Lothar, HONDA, Tadashi, GRIBBLE, Gordon W.

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The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti–multiple myeloma (MM) activity and overcome bortezomib resistance by Chauhan, Dharminder, Li, Guilan, Podar, Klaus, Hideshima, Teru, Shringarpure, Reshma, Catley, Laurence, Mitsiades, Constantine, Munshi, Nikhil, Tai, Yu Tzu, Suh, Nanjoo, Gribble, Gordon W., Honda, Tadashi, Schlossman, Robert, Richardson, Paul, Sporn, Michael B., Anderson, Kenneth C.

“…The synthetic triterpenoid 2-cyano-3, 12-dioxooleana-1, 9-dien-28-oic acid (CDDO) induces apoptosis in leukemic cells. Here we show that CDDO and its new…”
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Syntheses of Polybrominated Indoles from the Red Alga Laurencia brongniartii and the Brittle Star Ophiocoma erinaceus by Liu, Yanbing, Gribble, Gordon W

“…The red alga Laurencia brongniartii and brittle star Ophiocoma erinaceus metabolites 2,3,6-tribromo-1-methylindole (1) and 2,3,5,6-tetrabromo-1-methylindole…”
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