Search Results - "GREVEL, J"

Current Use and Developments Needed for Optimal Design in Pharmacometrics: A Study Performed Among DDMoRe's European Federation of Pharmaceutical Industries and Associations Members by Mentré, F, Chenel, M, Comets, E, Grevel, J, Hooker, A, Karlsson, MO, Lavielle, M, Gueorguieva, I

“…Methods and software tools for optimal design in nonlinear mixed effect models, based on the Fisher information matrix, have been developed for a decade.1,2…”
Get full text

Absorption of cyclosporine A after oral dosing by Grevel, J

“…Variability in the absorption of CsA seems to contribute to the observed lack of correlation between the size of the oral dose and the trough concentration at…”
Get more information

Significance of cyclosporine pharmacokinetics by Grevel, J

Get more information

Adrenochrome reaction implicates oxygen radicals in metabolism of cyclosporine A and FK-506 in rat and human liver microsomes by Ahmed, S S, Strobel, H W, Napoli, K L, Grevel, J

“…The role of oxygen radicals in the metabolism of cyclosporine A (CyA), FR900506 (FK-506) and carbon tetrachloride (CCl4) catalyzed by the cytochrome P450…”
Get more information

Phase I dose-escalation study of the pan-PI3 K inhibitor copanlisib in children and adolescents with relapsed/refractory solid tumors by Macy, M., Cash, T., Pinto, N., Pressey, J.G., Szalontay, L., Furman, W.L., Bukowinski, A., Foster, J.H., Friedman, G.K., HaDuong, J., Fox, E., Weigel, B.J., Grevel, J., Huang, F., Phelps, C., Childs, B.H., Chung, J., Chaturvedi, S., Schulz, A., DuBois, S.G.

Get full text

P-261 Pharmacokinetics of regorafenib in the phase 3 CONCUR and CORRECT trials in patients with metastatic colorectal cancer (mCRC) by Cleton, A., Sturm, I., Jirakova Trnkova, Z., Grevel, J., Fiala-Buskies, S., Lettieri, J.

Get full text

Cyclosporine monitoring in renal transplantation: area under the curve monitoring is superior to trough-level monitoring by Grevel, J, Welsh, M S, Kahan, B D

“…Trough levels (TL) of cyclosporine (CS) measured in serum by the polyclonal radioimmunoassay (SR) are useful for dissecting the etiology of clinical events,…”
Get more information

Pharmacodynamic models of various beta blockers: an explanation for the long duration of action of bopindolol by Grevel, J

“…Models describing the time course of effects (pharmacodynamic models) of various beta blockers in man are used to explain the long duration of action of…”
Get more information

Evaluation of the Population Pharmacokinetic Properties of Lidocaine and its Metabolites After Long-Term Multiple Applications of a Lidocaine Plaster in Post-Herpetic Neuralgia Patients by Bursi, Roberta, Piana, Chiara, Grevel, Joachim, Huntjens, Dymphy, Boesl, Irmgard

“…Background and Objectives Lidocaine 5% medicated plaster is the first lidocaine containing product for chronic use. As no previous investigations have been…”
Get full text

Oxygen radical formation by the cytochrome P450 system as a cellular mechanism for cyclosporine toxicity by Serino, F, Grevel, J, Napoli, K L, Kahan, B D, Strobel, H W

Get more information

Evaluation of exposure of regorafenib and its metabolites in cancer patients with renal impairment by modelling, simulation, and clinical study by Block, M., Ploeger, B., Grevel, J., Schnizler, K., Gerisch, M., Hafner, F.-T., Reschke, S., Huang, F., Trnkova, Z.J., Sturm, I., Cleton, A.

Get full text

Evaluation of exposure of regorafenib (REG) and its metabolites in pediatric patients by modeling, simulation, and clinical study by Ploeger, B., Grevel, J., Frede, M., Block, M., Schnizler, K., Gerisch, M., Hafner, F.-T., Trnkova, Z.J., Agostinho, A.C., Sturm, I., Cleton, A.

Get full text

Abbreviated three-point kinetic profile in the 12-hour area under the curve for pharmacokinetic monitoring of cyclosporine by Serino, F, Citterio, F, Pozzetto, U, Grevel, J, Castagneto, M

Get more information

Pharmacokinetics, metabolism and interactions of ciclosporin by Grevel, J

Get more information

Pharmacokinetics of oral cyclosporin A (Sandimmun) in healthy subjects by Grevel, J, Nüesch, E, Abisch, E, Kutz, K

“…Extensive pharmacokinetic (PK) profiles after oral dosing of 300 mg cyclosporin A (CsA) were determined in whole blood by radioimmunoassay (RIA) in 14 healthy…”
Get full text

Preemptive transplantation--an analysis of benefits and hazards in 85 cases by Katz, S M, Kerman, R H, Golden, D, Grevel, J, Camel, S, Lewis, R M, Van Buren, C T, Kahan, B D

“…The benefit of transplantation without prior dialysis might be contravened by the failure to develop possible immunologic disabilities associated with chronic…”
Get more information

Area under the curve monitoring of cyclosporine therapy: the early posttransplant period by Grevel, J, Kahan, B D

“…The impact of a new monitoring strategy on whole blood concentrations of cyclosporine measured by a specific monoclonal radioimmunoassay was investigated in a…”
Get more information

Treatment of experimental stroke with opiate antagonists. Effects on neurological function, infarct size, and survival by Baskin, D S, Hosobuchi, Y, Grevel, J C

“…The effects are reported of acute and long-term continuous administration of three opiate antagonists--naloxone, naltrexone, and diprenorphine--on neurological…”
Get more information

The relevance of pharmacokinetics to optimal intravenous anesthesia by Grevel, J, Whiting, B

Get full text

Cyclosporin A pharmacokinetics in liver transplant recipients in relation to biliary T-tube clamping and liver dysfunction by Naoumov, N V, Tredger, J M, Steward, C M, O'Grady, J G, Grevel, J, Niven, A, Whiting, B, Williams, R

“…Cyclosporin A pharmacokinetics were studied after oral (4-14 mg/kg body weight) and intravenous dosing (1.5-3.5 mg/kg) in 13 orthotopic liver transplant…”
Get full text