Search Results - "GRESS, Ronald"

Harnessing the biology of IL-7 for therapeutic application by Mackall, Crystal L, Fry, Terry J, Gress, Ronald E

“…Key Points Interleukin-7 (IL-7) is required for T cell development in mice and humans and is produced by stromal tissues rather than activated lymphocytes…”
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Posttransplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression by Wachsmuth, Lucas P, Patterson, Michael T, Eckhaus, Michael A, Venzon, David J, Gress, Ronald E, Kanakry, Christopher G

“…Posttransplantation cyclophosphamide (PTCy) recently has had a marked impact on human allogeneic hematopoietic cell transplantation (HCT). Yet our…”
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T cells expressing an anti–B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma by Ali, Syed Abbas, Shi, Victoria, Maric, Irina, Wang, Michael, Stroncek, David F., Rose, Jeremy J., Brudno, Jennifer N., Stetler-Stevenson, Maryalice, Feldman, Steven A., Hansen, Brenna G., Fellowes, Vicki S., Hakim, Frances T., Gress, Ronald E., Kochenderfer, James N.

“…Therapies with novel mechanisms of action are needed for multiple myeloma (MM). B-cell maturation antigen (BCMA) is expressed in most cases of MM. We conducted…”
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T Cells Genetically Modified to Express an Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor Cause Remissions of Poor-Prognosis Relapsed Multiple Myeloma by Brudno, Jennifer N, Maric, Irina, Hartman, Steven D, Rose, Jeremy J, Wang, Michael, Lam, Norris, Stetler-Stevenson, Maryalice, Salem, Dalia, Yuan, Constance, Pavletic, Steven, Kanakry, Jennifer A, Ali, Syed Abbas, Mikkilineni, Lekha, Feldman, Steven A, Stroncek, David F, Hansen, Brenna G, Lawrence, Judith, Patel, Rashmika, Hakim, Frances, Gress, Ronald E, Kochenderfer, James N

“…Purpose Therapies with novel mechanisms of action are needed for multiple myeloma (MM). T cells can be genetically modified to express chimeric antigen…”
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Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies by Sabatino, Marianna, Hu, Jinhui, Sommariva, Michele, Gautam, Sanjivan, Fellowes, Vicki, Hocker, James D., Dougherty, Sean, Qin, Haiying, Klebanoff, Christopher A., Fry, Terry J., Gress, Ronald E., Kochenderfer, James N., Stroncek, David F., Ji, Yun, Gattinoni, Luca

“…Long-lived, self-renewing, multipotent T memory stem cells (TSCM) can trigger profound and sustained tumor regression but their rareness poses a major hurdle…”
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Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma by Brudno, Jennifer N., Lam, Norris, Vanasse, Danielle, Shen, Yueh-wei, Rose, Jeremy J., Rossi, John, Xue, Allen, Bot, Adrian, Scholler, Nathalie, Mikkilineni, Lekha, Roschewski, Mark, Dean, Robert, Cachau, Raul, Youkharibache, Philippe, Patel, Rashmika, Hansen, Brenna, Stroncek, David F., Rosenberg, Steven A., Gress, Ronald E., Kochenderfer, James N.

“…Anti-CD19 chimeric antigen receptor (CAR)-expressing T cells are an effective treatment for B-cell lymphoma, but often cause neurologic toxicity. We treated 20…”
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Tumor-Evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4+ T Cells to T-Regulatory Cells by OLKHANUD, Purevdorj B, DAMDINSUREN, Bazarragchaa, BODOGAI, Monica, GRESS, Ronald E, SEN, Ranjan, WEJKSZA, Katarzyna, MALCHINKHUU, Enkhzol, WERSTO, Robert P, BIRAGYN, Arya

“…Pulmonary metastasis of breast cancer requires recruitment and expansion of T-regulatory cells (Treg) that promote escape from host protective immune cells…”
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B-cell Maturation Antigen Is a Promising Target for Adoptive T-cell Therapy of Multiple Myeloma by CARPENTER, Robert O, EVBUOMWAN, Moses O, PITTALUGA, Stefania, ROSE, Jeremy J, RAFFELD, Mark, SHICHENG YANG, GRESS, Ronald E, HAKIM, Frances T, KOCHENDERFER, James N

“…Multiple myeloma is a usually incurable malignancy of plasma cells. New therapies are urgently needed for multiple myeloma. Adoptive transfer of chimeric…”
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Allogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease by Brudno, Jennifer N, Somerville, Robert P T, Shi, Victoria, Rose, Jeremy J, Halverson, David C, Fowler, Daniel H, Gea-Banacloche, Juan C, Pavletic, Steven Z, Hickstein, Dennis D, Lu, Tangying L, Feldman, Steven A, Iwamoto, Alexander T, Kurlander, Roger, Maric, Irina, Goy, Andre, Hansen, Brenna G, Wilder, Jennifer S, Blacklock-Schuver, Bazetta, Hakim, Frances T, Rosenberg, Steven A, Gress, Ronald E, Kochenderfer, James N

“…Progressive malignancy is the leading cause of death after allogeneic hematopoietic stem-cell transplantation (alloHSCT). After alloHSCT, B-cell malignancies…”
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Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation by Kochenderfer, James N., Dudley, Mark E., Carpenter, Robert O., Kassim, Sadik H., Rose, Jeremy J., Telford, William G., Hakim, Frances T., Halverson, David C., Fowler, Daniel H., Hardy, Nancy M., Mato, Anthony R., Hickstein, Dennis D., Gea-Banacloche, Juan C., Pavletic, Steven Z., Sportes, Claude, Maric, Irina, Feldman, Steven A., Hansen, Brenna G., Wilder, Jennifer S., Blacklock-Schuver, Bazetta, Jena, Bipulendu, Bishop, Michael R., Gress, Ronald E., Rosenberg, Steven A.

“…New treatments are needed for B-cell malignancies persisting after allogeneic hematopoietic stem cell transplantation (alloHSCT). We conducted a clinical trial…”
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Anti-CD20 Antibody Promotes Cancer Escape via Enrichment of Tumor-Evoked Regulatory B Cells Expressing Low Levels of CD20 and CD137L by BODOGAI, Monica, CHANG, Catalina Lee, WEJKSZA, Katarzyna, JINPING LAI, MERINO, Maria, WERSTO, Robert P, GRESS, Ronald E, CHAN, Andrew C, HESDORFFER, Charles, BIRAGYN, Arya

“…The possible therapeutic benefits of B-cell depletion in combating tumoral immune escape have been debated. In support of this concept, metastasis of highly…”
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Analysis of Cell Proliferation and Homeostasis Using EdU Labeling by Flomerfelt, Francis A, Gress, Ronald E

“…Determination of cellular proliferation and population turnover is an important tool for research on lymphoid cell function. Historically this has been done…”
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The Abundance and Availability of Cytokine Receptor IL-2Rβ (CD122) Constrain the Lymphopenia-Induced Homeostatic Proliferation of Naive CD4 T Cells by Keller, Hilary R, Kim, Hye Kyung, Jo, Yuna, Gress, Ronald E, Hong, Changwan, Park, Jung-Hyun

“…Lymphopenia-induced homeostatic proliferation (LIP) is a critical mechanism for restoring T cell immunity upon lymphodepleting insults or infections. LIP is…”
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Siglec-6 is a target for chimeric antigen receptor T-cell treatment of chronic lymphocytic leukemia by Kovalovsky, Damian, Yoon, Jeong Heon, Cyr, Matthew G., Simon, Samantha, Voynova, Elisaveta, Rader, Christoph, Wiestner, Adrian, Alejo, Julie, Pittaluga, Stefania, Gress, Ronald E.

“…The only current curative treatment for chronic lymphocytic leukemia (CLL) is allogenic hematopoietic stem cell transplantation. Chimeric antigen receptor…”
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Bone Marrow‐Derived Mesenchymal Stromal Cells Harness Purinergenic Signaling to Tolerize Human Th1 Cells In Vivo by Amarnath, Shoba, Foley, Jason E., Farthing, Don E., Gress, Ronald E., Laurence, Arian, Eckhaus, Michael A., Métais, Jean‐Yves, Rose, Jeremy J., Hakim, Frances T., Felizardo, Tania C., Cheng, Austin V., Robey, Pamela G., Stroncek, David E., Sabatino, Marianna, Battiwalla, Minoo, Ito, Sawa, Fowler, Daniel H., Barrett, Austin J.

“…The use of bone marrow‐derived mesenchymal stromal cells (BMSC) in the treatment of alloimmune and autoimmune conditions has generated much interest, yet an…”
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Microbial ligand-independent regulation of lymphopoiesis by NOD1 by Iwamura, Chiaki, Ohnuki, Hidetaka, Flomerfelt, Francis A., Zheng, Lixin, Carletti, Alexie, Wakashin, Hidefumi, Mikami, Yohei, Brooks, Stephen R., Kanno, Yuka, Gress, Ronald E., Tosato, Giovanna, Nakayama, Toshinori, O’Shea, John J., Sher, Alan, Jankovic, Dragana

“…Aberrant differentiation of progenitor cells in the hematopoietic system is known to severely impact host immune responsiveness. Here we demonstrate that NOD1,…”
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The Timing and Abundance of IL-2Rβ (CD122) Expression Control Thymic iNKT Cell Generation and NKT1 Subset Differentiation by Won, Hee Yeun, Kim, Hye Kyung, Crossman, Assiatu, Awasthi, Parirokh, Gress, Ronald E., Park, Jung-Hyun

“…Invariant NKT ( i NKT) cells are thymus-generated innate-like T cells, comprised of three distinct subsets with divergent effector functions. The molecular…”
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In vivo deuterium magnetic resonance imaging of xenografted tumors following systemic administration of deuterated water by Brender, Jeffrey R., Assmann, Julian C., Farthing, Don E., Saito, Keita, Kishimoto, Shun, Warrick, Kathrynne A., Maglakelidze, Natella, Larus, Terri L., Merkle, Hellmut, Gress, Ronald E., Krishna, Murali C., Buxbaum, Nataliya P.

“…In vivo deuterated water ( 2 H 2 O) labeling leads to deuterium ( 2 H) incorporation into biomolecules of proliferating cells and provides the basis for its…”
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Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells by Singer, Alfred, Park, Jung-Hyun, Adoro, Stanley, Guinter, Terry, Erman, Batu, Alag, Amala S, Catalfamo, Marta, Kimura, Motoko Y, Cui, Yongzhi, Lucas, Philip J, Gress, Ronald E, Kubo, Masato, Hennighausen, Lothar, Feigenbaum, Lionel

“…Whether CD8-lineage specification and CD8 + T cell differentiation is dependent on intrathymic cytokines signaling is unclear. Singer and co-workers show that…”
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Thymic stromal lymphopoietin is a key mediator of breast cancer progression by Olkhanud, Purevdorj B, Rochman, Yrina, Bodogai, Monica, Malchinkhuu, Enkhzol, Wejksza, Katarzyna, Xu, Mai, Gress, Ronald E, Hesdorffer, Charles, Leonard, Warren J, Biragyn, Arya

“…Inflammation is a double-edged sword that can promote or suppress cancer progression. In this study, we report that thymic stromal lymphopoietin (TSLP), an…”
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