Search Results - "GRESHAM, H. D"

Role of CD47 as a Marker of Self on Red Blood Cells by Oldenborg, Per-Arne, Zheleznyak, Alex, Fang, Yi-Fu, Lagenaur, Carl F., Gresham, Hattie D., Lindberg, Frederik P.

“…The immune system recognizes invaders as foreign because they express determinants that are absent on host cells or because they lack "markers of self" that…”
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Serum amyloid P component and C-reactive protein mediate phagocytosis through murine Fc gamma Rs by Mold, C, Gresham, H D, Du Clos, T W

“…The pentraxins, serum amyloid P component (SAP) and C-reactive protein (CRP) are acute-phase serum proteins in mice and humans, respectively. Although SAP…”
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Decreased Resistance to Bacterial Infection and Granulocyte Defects in IAP-Deficient Mice by Lindberg, Frederik P., Bullard, Daniel C., Caver, Tony E., Gresham, Hattie D., Beaudet, Arthur L., Brown, Eric J.

“…Granulocyte [polymorphonuclear leucocyte (PMN)] migration to sites of infection and subsequent activation is essential for host defense. Gene-targeted mice…”
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A Novel Member of the Integrin Receptor Family Mediates Arg-Gly-Asp-Stimulated Neutrophil Phagocytosis by Gresham, Hattie D., Goodwin, Jennifer L., Allen, Paul M., Anderson, Donald C., Brown, Eric J.

“…Human neutrophils (PMN) express a heterodimeric receptor that has ligand binding specificity for the Arg-Gly-Asp (RGD) sequence within many adhesive proteins…”
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Entactin stimulates neutrophil adhesion and chemotaxis through interactions between its Arg-Gly-Asp (RGD) domain and the leukocyte response integrin by SENIOR, R. M, GRESHAM, H. D, GRIFFIN, G. L, BROWN, E. J, CHUNG, A. E

“…Entactin is an integral component of basement membranes that plays a major role in basement membrane assembly through its ability to bind avidly to both…”
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Cd47-Signal Regulatory Protein α (Sirpα) Regulates Fcγ and Complement Receptor–Mediated Phagocytosis by Oldenborg, Per-Arne, Gresham, Hattie D., Lindberg, Frederik P.

“…In autoimmune hemolytic anemia (AIHA), circulating red blood cells (RBCs) opsonized with autoantibody are recognized by macrophage Fcγ and complement…”
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Mechanism of inhibition of immunoglobulin G-mediated phagocytosis by monoclonal antibodies that recognize the mac-1 antigen by BROWN, E. J, BOHNSACK, J. F, GRESHAM, H. D

“…We have investigated the effects of the monoclonal antibodies against the cell surface molecule Mac-1 on C3bi-mediated rosetting and IgG-mediated rosetting and…”
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Spontaneous elaboration of transforming growth factor beta suppresses host defense against bacterial infection in autoimmune MRL/lpr mice by Lowrance, J H, O'Sullivan, F X, Caver, T E, Waegell, W, Gresham, H D

“…Infection with gram-negative and gram-positive bacteria remains a leading cause of death in patients with systemic lupus erythematosis (SLE), even in the…”
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Survival of Staphylococcus aureus Inside Neutrophils Contributes to Infection by Gresham, Hattie D, Lowrance, Jon H, Caver, Tony E, Wilson, Bridget S, Cheung, Ambrose L, Lindberg, Frederik P

“…Neutrophils have long been regarded as essential for host defense against Staphylococcus aureus infection. However, survival of the pathogen inside various…”
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Ligand binding specificity of the leukocyte response integrin expressed by human neutrophils by GRESHAM, H. D, ADAMS, S. P, BROWN, E. J

“…The ligand binding specificity of the leukocyte response integrin (LRI) expressed by polymorphonuclear leukocyte (PMN) was investigated by examining its…”
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Large scale isolation of functionally active components of the human complement system by Hammer, C H, Wirtz, G H, Renfer, L, Gresham, H D, Tack, B F

“…In the present work a scheme is presented for the isolation of multiple components of human complement in a functionally and biochemically pure state and with…”
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An immobile subset of plasma membrane CD11b/CD18 (Mac-1) is involved in phagocytosis of targets recognized by multiple receptors by Graham, IL, Gresham, HD, Brown, EJ

“…CD11b/CD18 is a heterodimeric leukocyte surface receptor which functions in both C3bi-ligand binding and homotypic and heterotypic cell adherence. We have…”
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Studies on the molecular mechanisms of human neutrophil Fc receptor-mediated phagocytosis. Evidence that a distinct pathway for activation of the respiratory burst results in reactive oxygen metabolite-dependent amplification of ingestion by GRESHAM, H. D, ZHELEZNYAK, A, MORMOL, J. S, BROWN, E. J

“…Human neutrophils (PMN) possess at least two distinct mechanisms for the ingestion of IgG-opsonized pathogens; one is independent of and the other is dependent…”
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An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction by Erb, L, Liu, J, Ockerhausen, J, Kong, Q, Garrad, R C, Griffin, K, Neal, C, Krugh, B, Santiago-Pérez, L I, González, F A, Gresham, H D, Turner, J T, Weisman, G A

“…The P2Y(2) nucleotide receptor (P2Y(2)R) contains the integrin-binding domain arginine-glycine-aspartic acid (RGD) in its first extracellular loop, raising the…”
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Expression of the 50-kDa integrin-associated protein on myeloid cells and erythrocytes by Rosales, C, Gresham, HD, Brown, EJ

“…Integrin-associated protein (IAP) is a 50-kDa intrinsic membrane protein that is involved in signal transduction during neutrophil activation by a variety of…”
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Studies on the molecular mechanisms of human Fc receptor-mediated phagocytosis: amplification of ingestion is dependent on the generation of reactive oxygen metabolites and is deficient in polymorphonuclear leukocytes from patients with chronic granulomatous disease by GRESHAM, H. D, MCGAR, J. A, SHACKELFORD, P. G, BROWN, E. J

“…Human PMN and monocytes both possess a mechanism for amplifying Fc receptor-mediated phagocytic function, which is dependent on activation of the respiratory…”
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Role for Plastin in Host Defense Distinguishes Integrin Signaling from Cell Adhesion and Spreading by Chen, Hua, Mocsai, Attila, Zhang, Hong, Ding, Rong-Xian, Morisaki, J.Hiroshi, White, Michael, Rothfork, Jacob M., Heiser, Patrick, Colucci-Guyon, Emma, Lowell, Clifford A., Gresham, Hattie D., Allen, Paul M., Brown, Eric J.

“…Integrin ligation activates both cell adhesion and signal transduction, in part through reorganization of the actin cytoskeleton. Plastins (also known as…”
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Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr by Vines, C M, Potter, J W, Xu, Y, Geahlen, R L, Costello, P S, Tybulewicz, V L, Lowell, C A, Chang, P W, Gresham, H D, Willman, C L

“…While beta 2 integrin ligand-receptor recognition interactions are well characterized, less is known about how these events trigger signal transduction…”
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Molecular regulation of phagocyte function. Evidence for involvement of a guanosine triphosphate-binding protein in opsonin-mediated phagocytosis by monocytes by Brown, EJ, Newell, AM, Gresham, HD

“…Although many functions of phagocytes are known to be regulated by guanosine triphosphate (GTP)-binding proteins, phagocytosis itself has not been considered…”
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Cholera toxin and pertussis toxin regulate the Fc receptor-mediated phagocytic response of human neutrophils in a manner analogous to regulation by monoclonal antibody 1C2 by Gresham, HD, Clement, LT, Volanakis, JE, Brown, EJ

“…Data presented in this paper indicate that polymorphonuclear leukocyte (PMN) Fc receptor-mediated phagocytosis can be markedly augmented and that this…”
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