Search Results - "GREINER, Istvan"

One-Step, Catalyst-Free Continuous-Flow Method for the Rapid and Safe Synthesis of 1‑Substituted 1H‑Tetrazoles by Fülöp, Zsolt, Bana, Péter, Temesvári, Márton, Barabás, Júlia, Kazsu, Zoltán, Béni, Zoltán, Greiner, István, Éles, János

“…1-Substituted 1H-tetrazoles are valuable building blocks in medicinal chemistry; however, their limited synthetic accessibility constrains their use. A new…”
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Continuous Synthesis and Purification by Coupling a Multistep Flow Reaction with Centrifugal Partition Chromatography by Örkényi, Róbert, Éles, János, Faigl, Ferenc, Vincze, Péter, Prechl, Anita, Szakács, Zoltán, Kóti, János, Greiner, István

“…Continuous‐flow multistep synthesis is combined with quasi‐continuous final‐product purification to produce pure products from crude reaction mixtures. In the…”
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Synthesis and Characterization of New V 1A Antagonist Compounds: The Separation of Four Atropisomeric Stereoisomers by Szeleczky, Zsolt, Szakács, Zoltán, Bozó, Éva, Baska, Ferenc, Vukics, Krisztina, Lévai, Sándor, Temesvári, Krisztina, Vass, Elemér, Béni, Zoltán, Krámos, Balázs, Magdó, Ildikó, Szántay, Csaba, Kóti, János, Domány-Kovács, Katalin, Greiner, István, Bata, Imre

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Biomimetic Synthesis of Drug Metabolites in Batch and Continuous‐Flow Reactors by Fődi, Tamás, Ignácz, Gergő, Decsi, Balázs, Béni, Zoltán, Túrós, György I., Kupai, József, Weiser, Diána Balogh, Greiner, István, Huszthy, Péter, Balogh, György T.

“…A medium‐throughput screening (MTS) of biomimetic drug metabolite synthesis is developed by using an iron porphyrin catalyst. The microplate method, in…”
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Discovery of novel steroidal histamine H 3 receptor antagonists/inverse agonists. Part 2. Versatile steroidal carboxamide derivatives by Ledneczki, István, Némethy, Zsolt, Tapolcsányi, Pál, Éles, János, Greiner, István, Gábor, Eszter, Varga, Balázs, Balázs, Ottilia, Román, Viktor, Lévay, György, Mahó, Sándor

“…To further proceed with our previous work, novel steroid-based histamine H receptor antagonists were identified and characterized. Using an 'amine-to-amide'…”
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Discovery of novel steroidal histamine H 3 receptor antagonists/inverse agonists by Ledneczki, Istvan, Tapolcsányi, Pál, Gábor, Eszter, Éles, János, Greiner, István, Schmidt, Éva, Némethy, Zsolt, Kedves, Rita Soukupné, Balázs, Ottilia, Román, Viktor, Lévay, György, Mahó, Sándor

“…Emerging from an HTS campaign, novel steroid-based histamine H receptor antagonists were identified and characterized. Structural moieties of the hit compounds…”
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“Greener” synthesis of bisphosphonic/dronic acid derivatives by Kovács Rita, Grün Alajos, Garadnay Sándor, Greiner István, Keglevich György

“…According to literature, the synthesis of dronic acid derivatives from the corresponding carboxylic acids using phosphorus trichloride and phosphorous acid as…”
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The route from problem to solution in multistep continuous flow synthesis of pharmaceutical compounds by Bana, Péter, Örkényi, Róbert, Lövei, Klára, Lakó, Ágnes, Túrós, György István, Éles, János, Faigl, Ferenc, Greiner, István

“…[Display omitted] Recent advances in the field of continuous flow chemistry allow the multistep preparation of complex molecules such as APIs (Active…”
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A Mechanistic Study on the Formation of Dronic Acids by Ábrányi-Balogh, Péter, Greiner, István, Keglevich, György

“…Dronic acid derivatives, important drugs against bone diseases, may be synthesized from the corresponding substituted acetic acid either by reaction with…”
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Selective NR1/2B N-Methyl-d-aspartate Receptor Antagonists among Indole-2-carboxamides and Benzimidazole-2-carboxamides by Borza, István, Bozó, Éva, Barta-Szalai, Gizella, Kiss, Csilla, Tárkányi, Gábor, Demeter, Ádám, Gáti, Tamás, Háda, Viktor, Kolok, Sándor, Gere, Anikó, Fodor, László, Nagy, József, Galgóczy, Kornél, Magdó, Ildikó, Ágai, Béla, Fetter, József, Bertha, Ferenc, Keserü, György M, Horváth, Csilla, Farkas, Sándor, Greiner, István, Domány, György

“…(4-Benzylpiperidine-1-yl)-(6-hydroxy-1H-indole-2-yl)-methanone (6a) derived from (E)-1-(4-benzylpiperidin-1-yl)-3-(4-hydroxy-phenyl)-propenone (5) was…”
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C-N Bond Formation by Consecutive Continuous-Flow Reductions towards A Medicinally Relevant Piperazine Derivative by Fülöp, Zsolt, Bana, Péter, Greiner, István, Éles, János

“…A new, continuous-flow consecutive reduction method was developed for the C-N bond formation in the synthesis of the key intermediate of the antipsychotic drug…”
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Discovery of Novel Steroid-Based Histamine H3 Receptor Antagonists/Inverse Agonists by Ledneczki, István, Tapolcsányi, Pál, Gábor, Eszter, Éles, János, Barabás, Júlia, Béni, Zoltán, Varga, Balázs, Balázs, Ottilia, Román, Viktor, Fodor, László, Szikra, Judit, Vastag, Mónika, Lévay, György, Schmidt, Éva, Lendvai, Balázs, Greiner, István, Kiss, Béla, Némethy, Zsolt, Mahó, Sándor

“…Steroid-based histamine H3 receptor antagonists (d-homoazasteroids) were designed by combining distinct structural elements of HTS hit molecules. They were…”
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Discovery and Characterization of RGH-122, a Potent, Selective, and Orally Bioavailable V1a Receptor Antagonist by Baska, Ferenc, Bozó, Éva, Szeleczky, Zsolt, Szántó, Gábor, Vukics, Krisztina, Szakács, Zoltán, Domány-Kovács, Katalin, Kurkó, Dalma, Vass, Elemér, Thán, Márta, Vastag, Mónika, Temesvári, Krisztina, Lévai, Sándor, Halász, Attila Sándor, Szondiné Kordás, Krisztina, Román, Viktor, Greiner, István, Bata, Imre

“…The V1a receptor is a major contributor in mediating the social and emotional effects of arginine-vasopressin (AVP); therefore it represents a promising target…”
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Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560) by Ledneczki, István, Némethy, Zsolt, Molnár, Katalin Dudásné, Tapolcsányi, Pál, Ilkei, Viktor, Vágó, István, Kolok, Sándor, Thán, Márta, Laszy, Judit, Balázs, Ottilia, Krámos, Balázs, Szigetvári, Áron, Bata, Imre, Makó, Attila, Visegrády, András, Fodor, László, Vastag, Mónika, Lévay, György, Lendvai, Balázs, Greiner, István, Éles, János

“…During optimization of a previously identified lead compound, attempts were made to optimize the reactive indole structural element, the suboptimal metabolic…”
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Design, synthesis and biological evaluation of novel cyclic malonamide derivatives as selective RIPK1 inhibitors by Petró, József Levente, Bényei, Gyula, Bana, Péter, Linke, Nikolett, Horti, Ferenc, Szabó, Judit Eszter, Szalai, Krisztina Katalin, Hornyánszky, Gábor, Greiner, István, Éles, János

“…[Display omitted] Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) plays a key role in cell death and inflammation. RIPK1 is a well-established…”
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Harnessing dual-mode RIPK1 ligands for cross-species anti-necroptosis inhibitor compounds by Levente Petró, József, Bana, Péter, Linke, Nikolett, Eszter Szabó, Judit, Katalin Szalai, Krisztina, Kálomista, Ildikó, Gábor Vass, Csaba, Hornyánszky, Gábor, Greiner, István, Éles, János

“…[Display omitted] •Synthesis and biological evaluation of novel mixed type RIPK1 inhibitors.•Installation of a rigid acetylene moiety enhanced the…”
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Fragment Based Optimization of Metabotropic Glutamate Receptor 2 (mGluR2) Positive Allosteric Modulators in the Absence of Structural Information by Szabó, György, Túrós, György I, Kolok, Sándor, Vastag, Mónika, Sánta, Zsuzsanna, Dékány, Miklós, Lévay, György I, Greiner, István, Natsumi, Minami, Tatsuya, Watanabe, Keserű, György M

“…Metabotropic glutamate receptor 2 (mGluR2) positive allosteric modulators (PAMs) have been implicated as potential pharmacotherapy for psychiatric conditions…”
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Fragment-Based Optimization of Dihydropyrazino-Benzimidazolones as Metabotropic Glutamate Receptor‑2 Positive Allosteric Modulators against Migraine by Szabó, György, Erdélyi, Péter, Kolok, Sándor, Vastag, Mónika, Halász, Attila S, Kis-Varga, Istvánné, Lévay, György I, Béni, Zoltán, Kóti, János, Greiner, István, Keserű, György M

“…Our previous scaffold-hopping attempts resulted in dihydropyrazino-benzimidazoles as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators…”
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Novel-Type GABAB PAMs: Structure–Activity Relationship in Light of the Protein Structure by Krámos, Balázs, Hadady, Zsuzsa, Makó, Attila, Szántó, Gábor, Felföldi, Nóra, Magdó, Ildikó, Bobok, Amrita Ágnes, Bata, Imre, Román, Viktor, Visegrády, András, Keserű, György M., Greiner, István, Éles, János

“…Selecting a known HTS hit with the pyrazolo­[1,5-a]­pyrimidine core, our project was started from CMPPE, and its optimization was driven by a ligand-based…”
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Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents by Nagy, Dávid Illés, Grün, Alajos, Garadnay, Sándor, Greiner, István, Keglevich, György

“…The syntheses of hydroxymethylenebisphosphonic acid derivatives (dronic acid derivatives) starting from the corresponding substituted acetic acids and…”
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