Search Results - "GREINACHER, A"

Autoimmune heparin‐induced thrombocytopenia by Greinacher, A., Selleng, K., Warkentin, T. E.

“…Summary Autoimmune heparin‐induced thrombocytopenia (aHIT) indicates the presence in patients of anti‐platelet factor 4 (PF4)–polyanion antibodies that are…”
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Heparin‐induced thrombocytopenia by GREINACHER, A.

“…Heparin‐induced thrombocytopenia (HIT), typically occurring in the second week of heparin therapy, is an antibody‐mediated adverse drug reaction associated…”
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Immunogenic but effective: the HIT‐fondaparinux brain puzzler by GREINACHER, A.

“…See also Warkentin TE, Pai M, Sheppard JI, Schulman S, Spyropoulos AC, Eikelboom JW. Fondaparinux treatment of acute heparininduced thrombocytopenia confirmed…”
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Platelets kill bacteria by bridging innate and adaptive immunity via platelet factor 4 and FcγRIIA by Palankar, R., Kohler, T. P., Krauel, K., Wesche, J., Hammerschmidt, S., Greinacher, A.

“…Essentials Human platelets specifically interact with IgG opsonized bacteria through FcγRIIA. Platelet factor 4 (PF4) binds to polyanions (P) and undergoes a…”
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An open conformation of ADAMTS‐13 is a hallmark of acute acquired thrombotic thrombocytopenic purpura by Roose, E., Schelpe, A. S., Joly, B. S., Peetermans, M., Verhamme, P., Voorberg, J., Greinacher, A., Deckmyn, H., De Meyer, S. F., Coppo, P., Veyradier, A., Vanhoorelbeke, K.

“…Essentials Conformational changes in ADAMTS‐13 are part of its mode‐of‐action. The murine anti‐ADAMTS‐13 antibody 1C4 discriminates between folded and open…”
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The utility of viscoelastic methods in the prevention and treatment of bleeding and hospital‐associated venous thromboembolism in perioperative care: guidance from the SSC of the ISTH by Thomas, W., Samama, C.‐M., Greinacher, A., Hunt, B.J.

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Laboratory testing for heparin‐induced thrombocytopenia: a conceptual framework and implications for diagnosis by WARKENTIN, T. E., GREINACHER, A., GRUEL, Y., ASTER, R. H., CHONG, B. H.

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Evaluation of pretest clinical score (4 T's) for the diagnosis of heparin‐induced thrombocytopenia in two clinical settings by LO, G. K., JUHL, D., WARKENTIN, T. E., SIGOUIN, C. S., EICHLER, P., GREINACHER, A.

“…Background: Heparin‐induced thrombocytopenia (HIT) is a prothrombotic adverse drug reaction caused by heparin. As thrombocytopenia is common in hospitalized…”
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Diagnosis of inherited platelet disorders on a blood smear: a tool to facilitate worldwide diagnosis of platelet disorders by Greinacher, A., Pecci, A., Kunishima, S., Althaus, K., Nurden, P., Balduini, C. L., Bakchoul, T.

“…Essentials There are many hereditary platelet disorders (HPD) but diagnosing these is challenging. We provide a method to diagnose several HPDs using standard…”
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Use of factor concentrates for the management of perioperative bleeding: guidance from the SSC of the ISTH by Godier, A., Greinacher, A., Faraoni, D., Levy, J. H., Samama, C. M.

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Early‐onset and persisting thrombocytopenia in post‐cardiac surgery patients is rarely due to heparin‐induced thrombocytopenia, even when antibody tests are positive by SELLENG, S., MALOWSKY, B., STROBEL, U., WESSEL, A., ITTERMANN, T., WOLLERT, H.‐G., WARKENTIN, T. E., GREINACHER, A.

“…See also Gruel Y, Pouplard C. Post‐operative platelet count profile: the most reliable tool for identifying patients with true heparin‐induced thrombocypenia…”
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Heparin‐induced thrombocytopenia: a prospective study on the incidence, platelet‐activating capacity and clinical significance of antiplatelet factor 4/heparin antibodies of the IgG, IgM, and IgA classes by GREINACHER, A., JUHL, D., STROBEL, U., WESSEL, A., LUBENOW, N., SELLENG, K., EICHLER, P., WARKENTIN, T. E.

“…Introduction: Platelet‐activating antiplatelet factor 4/heparin (anti‐PF4/heparin) antibodies are the major cause of heparin‐induced thrombocytopenia (HIT)…”
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Preoperative platelet transfusions to reverse antiplatelet therapy for urgent non‐cardiac surgery: an observational cohort study by Baschin, M., Selleng, S., Hummel, A., Diedrich, S., Schroeder, H. W., Kohlmann, T., Westphal, A., Greinacher, A., Thiele, T.

“…Essentials An increasing number of patients requiring surgery receive antiplatelet therapy (APT). We analyzed 181 patients receiving presurgery platelet…”
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Another surprising finding in heparin‐induced thrombocytopenia – eat big by Greinacher, A., Delcea, M.

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Lepirudin in patients with heparin‐induced thrombocytopenia – results of the third prospective study (HAT‐3) and a combined analysis of HAT‐1, HAT‐2, and HAT‐3 by LUBENOW, N., EICHLER, P., LIETZ, T., GREINACHER, A.

“…Objectives: To assess efficacy and safety of lepirudin in patients with heparin‐induced thrombocytopenia (HIT) in a prospective study (HAT‐3) as well as in a…”
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Current insights into the laboratory diagnosis of HIT by Bakchoul, T., Zöllner, H., Greinacher, A.

“…Summary Heparin‐induced thrombocytopenia (HIT) is an adverse drug reaction and prothrombotic disorder caused by immunization against platelet factor 4 (PF4)…”
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Anaphylactic and anaphylactoid reactions associated with lepirudin in patients with heparin-induced thrombocytopenia by GREINACHER, A, LUBENOW, N, EICHLER, P

“…Lepirudin (Refludan) is a hirudin derivative. It is a direct thrombin inhibitor obtained by recombinant technology from the medicinal leech and is approved for…”
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Predonation finger lancet punctures: a potential risk factor for interdonor pathogen transmission in the blood donor clinic by Greinacher, A., Lubenow, N.

“…Background and Objectives Point‐of‐care testing using capillary blood from a finger prick is widely used for predonation haemoglobin testing of blood donors…”
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Heparin‐induced thrombocytopenia: towards standardization of platelet factor 4/heparin antigen tests by GREINACHER, A., ITTERMANN, T., BAGEMÜHL, J., ALTHAUS, K., FÜRLL, B., SELLENG, S., LUBENOW, N., SCHELLONG, S., SHEPPARD, J. I., WARKENTIN, T.E.

“…Background: Laboratory confirmation of heparin‐induced thrombocytopenia (HIT) is based on detection of heparin‐dependent platelet‐activating antibodies…”
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Taking advantage of the non-anticoagulant effects of heparin by Greinacher, A

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