Search Results - "GREIDER, C. W"

Telomerase Activity, Cell Proliferation, and Cancer by Greider, Carol W.

“…Evidence from several different areas indicates that telomerase activity is often associated with cell proliferation, but evidence also suggests that there may…”
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Two Survivor Pathways That Allow Growth in the Absence of Telomerase Are Generated by Distinct Telomere Recombination Events by Chen, Qijun, Ijpma, Arne, Greider, Carol W.

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Telomere Length Predicts Replicative Capacity of Human Fibroblasts by Allsopp, Richard C., Vaziri, Homayoun, Patterson, Christopher, Goldstein, Samuel, Younglai, Edward V., Futcher, A. Bruce, Greider, Carol W., Harley, Calvin B.

“…When human fibroblasts from different donors are grown in vitro, only a small fraction of the variation in their finite replicative capacity is explained by…”
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Developmental and Tissue-Specific Regulation of Mouse Telomerase and Telomere Length by Prowse, Karen R., Greider, Carol W.

“…Telomere shortening and telomerase activation in human somatic cells have been implicated in cell immortalization and cellular senescence. To further study the…”
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Telomerase is processive by GREIDER, C. W

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The RNA Component of Human Telomerase by Feng, Junli, Funk, Walter D., Wang, Sy-Shi, Weinrich, Scott L., Avilion, Ariel A., Chiu, Choy-Pik, Adams, Robert R., Chang, Edwin, Allsopp, Richard C., Yu, Jinghua, Le, Siyuan, West, Michael D., Harley, Calvin B., Andrews, William H., Greider, Carol W., Villeponteau, Bryant

“…Eukaryotic chromosomes are capped with repetitive telomere sequences that protect the ends from damage and rearrangements. Telomere repeats are synthesized by…”
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Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues by AVILION, A. A, PIATYSZEK, M. A, JYOTHI GUPTA, SHAY, J. W, BACCHETTI, S, GREIDER, C. W

“…Telomerase activity has been detected in many human immortal cells lines and in tumor tissues, whereas it is generally absent from primary cell strains and…”
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Telomere dysfunction triggers developmentally regulated germ cell apoptosis by Hemann, M T, Rudolph, K L, Strong, M A, DePinho, R A, Chin, L, Greider, C W

“…Telomere dysfunction results in fertility defects in a number of organisms. Although data from fission yeast and Caenorhabditis elegans suggests that telomere…”
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Functional Characterization and Developmental Regulation of Mouse Telomerase RNA by Blasco, María A., Funk, Walter, Villeponteau, Bryant, Greider, Carol W.

“…Telomerase synthesizes telomeric DNA repeats onto chromosome ends de novo. The mouse telomerase RNA component was cloned and contained only 65 percent sequence…”
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Telomerase activation: one step on the road to cancer? by Greider, Carol W

“…Ever since the discovery that telomeres are short in cancer cells and telomerase is activated in immortal cells, telomerase has been an oncogene wannabe…”
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Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity by Counter, C.M., Avilion, A.A., LeFeuvre, C.E., Stewart, N.G., Greider, C.W., Harley, C.B., Bacchetti, S.

“…Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since telomeres permit complete replication of eukaryotic chromosomes and…”
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Telomeres shorten during ageing of human fibroblasts by Harley, Calvin B, Futcher, A. Bruce, Greider, Carol W

“…The terminus of a DNA helix has been called its Achilles' heel. Thus to prevent possible incomplete replication and instability of the termini of linear DNA,…”
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Telomere end-replication problem and cell aging by Levy, M Z, Allsopp, R C, Futcher, A B, Greider, C W, Harley, C B

“…Since DNA polymerase requires a labile primer to initiate unidirectional 5'-3' synthesis, some bases at the 3' end of each template strand are not copied…”
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Telomerase activity in germline and embryonic cells of Xenopus by Mantell, L.L., Greider, C.W.

“…Telomerase is a ribonucleoprotein which synthesizes telomere repeats onto chromosome ends. Telomerase activity is involved in telomere length maintenance. We…”
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Identification of a Nonprocessive Telomerase Activity from Mouse Cells by Prowse, Karen R., Avilion, Ariel A., Greider, Carol W.

“…Telomerase activity was identified in extracts from several different mouse cell lines. Addition of telomeric TTAGGG repeats was specific to telomeric…”
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Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA by Autexier, C., Pruzan, R., Funk, W. D., Greider, C. W.

“…Telomerase is a ribonucleoprotein that catalyzes telomere elongation through the addition of TTAGGG repeats in humans. Activation of telomerase is often…”
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Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation by COLLINS, K, GREIDER, C. W

“…Telomerase is a ribonucleoprotein enzyme that adds telomeric repeats to chromosomes, maintaining telomere length and stabilizing chromosome ends. In vitro,…”
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The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability by Hemann, Michael T, Strong, Margaret A, Hao, Ling-Yang, Greider, Carol W

“…Loss of telomere function can induce cell cycle arrest and apoptosis. To investigate the processes that trigger cellular responses to telomere dysfunction, we…”
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Telomerase RNA levels limit the telomere length equilibrium by Greider, C W

“…Small functional RNAs play essential roles in many biological processes. Regulating the level of these small RNAs can be as important as maintaining their…”
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Functional reconstitution of wild-type and mutant Tetrahymena telomerase by AUTEXIER, C, GREIDER, C. W

“…Telomerase is a ribonucleoprotein that catalyzes telomere elongation in vitro and in vivo. The 159-nucleotide RNA component of Tetrahymena telomerase contains…”
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