Search Results - "GREGSON, N. A."

A controlled investigation of the cause of chronic idiopathic axonal polyneuropathy by Hughes, R. A. C., Umapathi, T., Gray, I. A., Gregson, N. A., Noori, M., Pannala, A. S., Proteggente, A., Swan, A. V.

“…To investigate the aetiology of chronic idiopathic axonal polyneuropathy (CIAP), 50 consecutive patients were compared with 50 control subjects from the same…”
Get full text

Patients with progressive multiple sclerosis have elevated antibodies to neurofilament subunit by SILBER, E, SEMRA, Y. K, GREGSON, N. A, SHARIEF, M. K

“…The cause of axonal loss, an important contributor to disability in MS, is poorly understood. This study investigated whether progression in MS is associated…”
Get full text

Pathogenesis of Guillain–Barré syndrome by Hughes, R.A.C, Hadden, R.D.M, Gregson, N.A, Smith, K.J

“…Recent neurophysiological and pathological studies have led to a reclassification of the diseases that underlie Guillain-Barré syndrome (GBS) into acute…”
Get full text

Paraneoplastic stiff person syndrome with metastatic adenocarcinoma and anti-Ri antibodies by MCCABE, D. J. H, TURNER, N. C, CHAO, D, LEFF, A, GREGSON, N. A, WOMERSLEY, H. J, MAK, I, PERKIN, G. D, SCHAPIRA, A. H. V

“…A 43-year-old woman presented with clinical and electrophysiologic features of stiff person syndrome (SPS), without abdominal or lumbar paraspinal muscle…”
Get full text

Campylobacter jejuni Infection and Guillain–Barré Syndrome by Rees, Jeremy H, Soudain, Sara E, Gregson, Norman A, Hughes, Richard A.C

“…Guillain–Barré syndrome is the most common cause of acute neuromuscular paralysis, 1 yet its cause and pathogenesis are unknown. In approximately two thirds of…”
Get full text

Characterisation of matrix metalloproteinases and the effects of a broad-spectrum inhibitor (BB-1101) in peripheral nerve regeneration by Demestre, M, Wells, G.M, Miller, K.M, Smith, K.J, Hughes, R.A.C, Gearing, A.J, Gregson, N.A

“…The effect of treatment with a broad-spectrum inhibitor (BB1101) of the matrix metalloproteinases (MMPs) on nerve regeneration and functional recovery after…”
Get full text

Characterization of matrix metalloproteinases in denervated muscle by Demestre, M., Orth, M., Wells, G. M., Gearing, A. J., Hughes, R. A. C., Gregson, N. A.

“…In a nerve crush model of denervation, we examined muscle matrix metalloproteinase (MMP) expression, localization and activity. In normal muscle, MMP mRNA…”
Get full text

A variant of multifocal motor neuropathy with acute, generalised presentation and persistent conduction blocks by Lefaucheur, J-P, Gregson, N A, Gray, I, von Raison, F, Bertocchi, M, Créange, A

“…Objective:Multifocal motor neuropathy with persistent conduction blocks is classically described as a chronic neuropathy with progressive onset, and acute…”
Get full text

Anti-PMP22 antibodies in patients with inflammatory neuropathy by Gabriel, C.M, Gregson, N.A, Hughes, R.A.C

“…An experimental model of inflammatory radiculoneuropathy is induced by immunising rats with peripheral myelin protein 22 (PMP22). We have investigated whether…”
Get full text

A combined inhibitor of matrix metalloproteinase activity and tumour necrosis factor-α processing attenuates experimental autoimmune neuritis by REDFORD, E. J, SMITH, K. J, GREGSON, N. A, DAVIES, M, HUGHES, P, GEARING, A. J. H, MILLER, K, HUGHES, R. A. C

“…Matrix metalloproteinases (MMPs) and the cytokine tumour necrosis factor (TNF)-alpha are implicated in the pathology of inflammatory demyelinating diseases of…”
Get full text

Immunological study of hereditary motor and sensory neuropathy type 1 a (HMSN1a) by GABRIEL, C. M, GREGSON, N. A, WOOD, N. W, HUGHES, R. A. C

Get full text

The distribution of CD1 molecules in inflammatory neuropathy by Khalili-Shirazi, A., Gregson, N.A., Londei, M., Summers, L., Hughes, R.A.C.

“…The CD1 molecules have been shown to present non-protein antigens, such as complex lipids to Mycobacteria, and may be important in presenting glycolipids which…”
Get full text

Effects on axonal conduction of anti-ganglioside sera and sera from patients with Guillain-Barré syndrome by Dilley, A, Gregson, N.A, Hadden, R.D.M, Smith, K.J

“…The efficacy of plasma exchange as a therapy for Guillain-Barré syndrome (GBS) suggests that humoral factors might contribute to the axonal conduction block…”
Get full text

Haemophilus influenzae as a possible cause of Guillain–Barré syndrome by Ju, Y.Y, Womersley, H, Pritchard, J, Gray, I, Hughes, R.A.C, Gregson, N.A

“…Recent reports have contained conflicting results on the relationship between antecedent Haemophilus influenzae infection and Guillain–Barré syndrome (GBS). To…”
Get full text

Human immunoglobulin ameliorates rat experimental autoimmune neuritis by GABRIEL, C. M, GREGSON, N. A, REDFORD, E. J, DAVIES, M, SMITH, K. J, HUGHES, R. A. C

“…Human immunoglobulin is an effective treatment for Guillain-Barré syndrome, although the mechanism of action is not understood. We have investigated the effect…”
Get full text

The clinical spectrum of peripheral neuropathies associated with benign monoclonal IgM, IgG and IgA paraproteinaemia : comparative clinical, immunological and nerve biopsy findings by YEUNG, K. B, THOMAS, P. K, KING, R. H. M, WADDY, H, WILL, R. G, HUGHES, R. A. C, GREGSON, N. A, LEIBOWITZ, S

“…Observations have been made on a consecutive series of 62 patients with peripheral neuropathy associated with benign monoclonal paraproteinaemia. The…”
Get full text

Accumulation of immunoglobulin across the 'blood-nerve barrier' in spinal roots in adoptive transfer experimental autoimmune neuritis by Hadden, R. D. M., Gregson, N. A., Gold, R., Smith, K. J., Hughes, R. A. C.

“…At the onset of Guillain–Barré syndrome, disruption of diffusion barriers, such as the blood–nerve barrier, probably increases the exposure of spinal roots and…”
Get full text

A novel metalloproteinase associated with brain myelin membranes. Isolation and characterization by CHANTRY, A, GREGSON, N. A, GLYNN, P

“…Brain myelin membrane preparations contain a metalloproteinase activity which degrades myelin basic protein (MBP). The activity was associated with lentil…”
Get full text

Efficacy of leukemia inhibitory factor in experimental autoimmune neuritis by Laurà, M, Gregson, N.A, Curmi, Y, Hughes, R.A.C

“…Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that exerts neurotrophic and myotrophic actions. We have investigated the effect of LIF in…”
Get full text

Effect of a Matrix Metalloproteinase Inhibitor (BB-1101) on Nerve Regeneration by DEMESTRE, MARIA, GREGSON, N. A., SMITH, K. J., MILLER, K. M., GEARING, A. J., HUGHES, R.A. C.

Get full text