Search Results - "GREENWALD, JASON"

Biology of Amyloid: Structure, Function, and Regulation by Greenwald, Jason, Riek, Roland

“…Amyloids are highly ordered cross-β sheet protein aggregates associated with many diseases including Alzheimer's disease, but also with biological functions…”
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On the Possible Amyloid Origin of Protein Folds by Greenwald, Jason, Riek, Roland

“…The diversity of protein folds is derived from the diversity of the underlying proteome. Such diversity must have originated from a so-called common ancestor:…”
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Amyloid Aggregates Arise from Amino Acid Condensations under Prebiotic Conditions by Greenwald, Jason, Friedmann, Michael P., Riek, Roland

“…Current theories on the origin of life reveal significant gaps in our understanding of the mechanisms that allowed simple chemical precursors to coalesce into…”
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A prebiotic template-directed peptide synthesis based on amyloids by Rout, Saroj K., Friedmann, Michael P., Riek, Roland, Greenwald, Jason

“…The prebiotic replication of information-coding molecules is a central problem concerning life’s origins. Here, we report that amyloids composed of short…”
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Towards Prebiotic Catalytic Amyloids Using High Throughput Screening by Friedmann, Michael P, Torbeev, Vladimir, Zelenay, Viviane, Sobol, Alexander, Greenwald, Jason, Riek, Roland

“…Enzymes are capable of directing complex stereospecific transformations and of accelerating reaction rates many orders of magnitude. As even the simplest known…”
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A structural rationale for reversible vs irreversible amyloid fibril formation from a single protein by Frey, Lukas, Zhou, Jiangtao, Cereghetti, Gea, Weber, Marco E., Rhyner, David, Pokharna, Aditya, Wenchel, Luca, Kadavath, Harindranath, Cao, Yiping, Meier, Beat H., Peter, Matthias, Greenwald, Jason, Riek, Roland, Mezzenga, Raffaele

“…Reversible and irreversible amyloids are two diverging cases of protein (mis)folding associated with the cross-β motif in the protein folding and aggregation…”
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The mechanism of toxicity in HET-S/HET-s prion incompatibility by Seuring, Carolin, Greenwald, Jason, Wasmer, Christian, Wepf, Roger, Saupe, Sven J, Meier, Beat H, Riek, Roland

“…The HET-s protein from the filamentous fungus Podospora anserina is a prion involved in a cell death reaction termed heterokaryon incompatibility. This…”
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On the pH-dependence of α-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation by Frey, Lukas, Ghosh, Dhiman, Qureshi, Bilal M, Rhyner, David, Guerrero-Ferreira, Ricardo, Pokharna, Aditya, Kwiatkowski, Witek, Serdiuk, Tetiana, Picotti, Paola, Riek, Roland, Greenwald, Jason

“…The aggregation of the protein α-synuclein is closely associated with several neurodegenerative disorders and as such the structures of the amyloid fibril…”
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Structure–activity relationship of amyloid fibrils by Maji, Samir K., Wang, Lei, Greenwald, Jason, Riek, Roland

“…Protein aggregation is a process in which proteins self-associate into imperfectly ordered macroscopic entities. Such aggregates are generally classified as…”
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NMR Structure of Mistic, a Membrane-Integrating Protein for Membrane Protein Expression by Roosild, Tarmo P, Greenwald, Jason, Vega, Mark, Castronovo, Samantha, Riek, Roland, Choe, Senyon

“…Although structure determination of soluble proteins has become routine, our understanding of membrane proteins has been limited by experimental bottlenecks in…”
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Narrowing SWNT diameter distribution using size-separated ferritin-based Fe catalysts by Durrer, Lukas, Greenwald, Jason, Helbling, Thomas, Muoth, Matthias, Riek, Roland, Hierold, Christofer

“…Sensors and devices made from single-walled carbon nanotubes (SWNTs) are most often electrically probed through metal leads contacting the semiconducting SWNTs…”
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FpvA bound to non-cognate pyoverdines: molecular basis of siderophore recognition by an iron transporter by Greenwald, Jason, Nader, Mirella, Celia, Hervé, Gruffaz, Christelle, Geoffroy, Valérie, Meyer, Jean-Marie, Schalk, Isabelle J, Pattus, Franc

“…The first step in the specific uptake of iron via siderophores in Gram-negative bacteria is the recognition and binding of a ferric siderophore by its cognate…”
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The Metal Dependence of Pyoverdine Interactions with Its Outer Membrane Receptor FpvA by Greenwald, Jason, Zeder-Lutz, Gabrielle, Hagege, Agnès, Celia, Hervé, Pattus, Franc

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Crystal structures of T. b. rhodesiense adenosine kinase complexed with inhibitor and activator: implications for catalysis and hyperactivation by Kuettel, Sabine, Greenwald, Jason, Kostrewa, Dirk, Ahmed, Shaheen, Scapozza, Leonardo, Perozzo, Remo

“…The essential purine salvage pathway of Trypanosoma brucei bears interesting catalytic enzymes for chemotherapeutic intervention of Human African…”
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Amyloid Aggregates Arise from Amino Acid Condensations under Prebiotic Conditions by Greenwald, Jason, Friedmann, Michael P., Riek, Roland

“…Current theories on the origin of life reveal significant gaps in our understanding of the mechanisms that allowed simple chemical precursors to coalesce into…”
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Peptide Amyloids in the Origin of Life by Greenwald, Jason, Kwiatkowski, Witek, Riek, Roland

“…How life can emerge from non-living matter is one of the fundamental mysteries of the universe. A bottom-up approach to this problem focuses on the potential…”
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Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain by Molteni, Valentina, Greenwald, Jason, Rhodes, Denise, Hwang, Young, Kwiatkowski, Witek, Bushman, Frederic D., Siegel, Jay S., Choe, Senyon

“…Integration of the reverse‐transcribed HIV cDNA into the host DNA is a required step in viral replication. The virus‐encoded integrase protein catalyzes the…”
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Identification of a Binding Site on the Type II Activin Receptor for Activin and Inhibin by Gray, Peter C., Greenwald, Jason, Blount, Amy L., Kunitake, Koichi S., Donaldson, Cynthia J., Choe, Senyon, Vale, Wylie

“…Type II activin receptors (ActRII and ActRIIB) are single-transmembrane domain serine/threonine kinase receptors that bind activin to initiate the signaling…”
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Expression, Purification, and Characterization of a Soluble Form of the First Extracellular Domain of the Human Type 1 Corticotropin Releasing Factor Receptor by Perrin, M H, Fischer, W H, Kunitake, K S, Craig, A G, Koerber, S C, Cervini, L A, Rivier, J E, Groppe, J C, Greenwald, J, Møller Nielsen, S, Vale, W W

“…The first extracellular domain (ECD-1) of the corticotropin releasing factor (CRF) type 1 receptor, (CRFR1), is important for binding of CRF ligands. A soluble…”
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Real Time Fluorescent Resonance Energy Transfer Visualization of Ferric Pyoverdine Uptake in Pseudomonas aeruginosa by Greenwald, Jason, Hoegy, Françoise, Nader, Mirella, Journet, Laure, Mislin, Gaëtan L.A., Graumann, Peter L., Schalk, Isabelle J.

“…To acquire iron, Pseudomonas aeruginosa secretes a major fluorescent siderophore, pyoverdine (PvdI), that chelates iron and shuttles it into the cells via the…”
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