Search Results - "GREENOUGH, Thomas"

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus by Choe, Hyeryun, Farzan, Michael, Li, Wenhui, Moore, Michael J, Vasilieva, Natalya, Sui, Jianhua, Wong, Swee Kee, Berne, Michael A, Somasundaran, Mohan, Sullivan, John L, Luzuriaga, Katherine, Greenough, Thomas C

“…Spike (S) proteins of coronaviruses, including the coronavirus that causes severe acute respiratory syndrome (SARS), associate with cellular receptors to…”
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A Novel Assay for Antibody-Dependent Cell-Mediated Cytotoxicity against HIV-1- or SIV-Infected Cells Reveals Incomplete Overlap with Antibodies Measured by Neutralization and Binding Assays by ALPERT, Michael D, HEYER, Lisa N, WILLIAMS, David E. J, HARVEY, Jackson D, GREENOUGH, Thomas, ALLHORN, Maria, EVANS, David T

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Uveitis and Systemic Inflammatory Markers in Convalescent Phase of Ebola Virus Disease by Chancellor, John R, Padmanabhan, Sriranjani P, Greenough, Thomas C, Sacra, Richard, Ellison, 3rd, Richard T, Madoff, Lawrence C, Droms, Rebecca J, Hinkle, David M, Asdourian, George K, Finberg, Robert W, Stroher, Ute, Uyeki, Timothy M, Cerón, Olga M

“…We report a case of probable Zaire Ebola virus-related ophthalmologic complications in a physician from the United States who contracted Ebola virus disease in…”
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Episomal viral cDNAs identify a reservoir that fuels viral rebound after treatment interruption and that contributes to treatment failure by Sharkey, Mark, Babic, Dunja Z, Greenough, Thomas, Gulick, Roy, Kuritzkes, Daniel R, Stevenson, Mario

“…Viral reservoirs that persist in HIV-1 infected individuals on antiretroviral therapy (ART) are the major obstacle to viral eradication. The identification and…”
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On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis by Hadinoto, Vey, Shapiro, Michael, Greenough, Thomas C., Sullivan, John L., Luzuriaga, Katherine, Thorley-Lawson, David A.

“…Memory B cells latently infected with Epstein-Barr virus (mBLats) in the blood disappear rapidly on presentation with acute symptomatic primary infection…”
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A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection by Greenough, Thomas C, Straubhaar, Juerg R, Kamga, Larisa, Weiss, Eric R, Brody, Robin M, McManus, Margaret M, Lambrecht, Linda K, Somasundaran, Mohan, Luzuriaga, Katherine F

“…Virus-specific CD8(+) T cells expand dramatically during acute EBV infection, and their persistence is important for lifelong control of EBV-related disease…”
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Programmed Death-1 expression on Epstein Barr virus specific CD8+ T cells varies by stage of infection, epitope specificity, and T-cell receptor usage by Greenough, Thomas C, Campellone, Shalyn C, Brody, Robin, Jain, Surbhi, Sanchez-Merino, Victor, Somasundaran, Mohan, Luzuriaga, Katherine

“…Programmed Death-1 (PD-1) is an inhibitory member of the CD28 family of molecules expressed on CD8+ T cells in response to antigenic stimulation. To better…”
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Retroviruses Pseudotyped with the Severe Acute Respiratory Syndrome Coronavirus Spike Protein Efficiently Infect Cells Expressing Angiotensin-Converting Enzyme 2 by MOORE, Michael J, DORFMAN, Tatyana, FARZAN, Michael, HYERYUN CHOE, WENHUI LI, SWEE KEE WONG, YANHAN LI, KUHN, Jens H, CODERRE, James, VASILIEVA, Natalya, ZHONGCHAO HAN, GREENOUGH, Thomas C

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Efficient Replication of Severe Acute Respiratory Syndrome Coronavirus in Mouse Cells Is Limited by Murine Angiotensin-Converting Enzyme 2 by WENHUI LI, GREENOUGH, Thomas C, MOORE, Michael J, VASILIEVA, Natalya, SOMASUNDARAN, Mohan, SULLIVAN, John L, FARZAN, Michael, CHOE, Hyeryun

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Down-Modulation of Mature Major Histocompatibility Complex Class II and Up-Regulation of Invariant Chain Cell Surface Expression Are Well-Conserved Functions of Human and Simian Immunodeficiency Virus nef Alleles by Schindler, Michael, Würfl, Stephanie, Benaroch, Philippe, Greenough, Thomas C, Daniels, Rod, Easterbrook, Philippa, Brenner, Matthias, Münch, Jan, Kirchhoff, Frank

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Development and Characterization of a Severe Acute Respiratory Syndrome—Associated Coronavirus—Neutralizing Human Monoclonal Antibody That Provides Effective Immunoprophylaxis in Mice by Greenough, Thomas C., Babcock, Gregory J., Roberts, Anjeanette, Hernandez, Hector J., Thomas, William D., Coccia, Jennifer A., Graziano, Robert F., Srinivasan, Mohan, Lowy, Israel, Finberg, Robert W, Subbarao, Kanta, Vogel, Leatrice, Somasundaran, Mohan, Luzuriaga, Katherine, Sullivan, John L., Ambrosino, Donna M.

“…Background. Severe acute respiratory syndrome (SARS) remains a significant public health concern after the epidemic in 2003. Human monoclonal antibodies (MAbs)…”
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Pneumonitis and Multi-Organ System Disease in Common Marmosets ( Callithrix jacchus) Infected with the Severe Acute Respiratory Syndrome-Associated Coronavirus by Greenough, Thomas C., Carville, Angela, Coderre, James, Somasundaran, Mohan, Sullivan, John L., Luzuriaga, Katherine, Mansfield, Keith

“…Severe acute respiratory syndrome (SARS) is a significant emerging infectious disease. Humans infected with the etiological agent, SARS-associated coronavirus…”
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Therapy with a Severe Acute Respiratory Syndrome–Associated Coronavirus–Neutralizing Human Monoclonal Antibody Reduces Disease Severity and Viral Burden in Golden Syrian Hamsters by Roberts, Anjeanette, Thomas, William D., Guarner, Jeannette, Lamirande, Elaine W., Babcock, Gregory J., Greenough, Thomas C., Vogel, Leatrice, Hayes, Norman, Sullivan, John L., Zaki, Sherif, Subbarao, Kanta, Ambrosino, Donna M.

“…BackgroundImmunotherapy with monoclonal antibodies (MAbs) offers safe interventions for the prevention of infection in patients after organ transplantation and…”
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Identification of Ongoing Human Immunodeficiency Virus Type 1 (HIV-1) Replication in Residual Viremia during Recombinant HIV-1 Poxvirus Immunizations in Patients with Clinically Undetectable Viral Loads on Durable Suppressive Highly Active Antiretroviral Therapy by SHIU, Carlum, CUNNINGHAM, Coleen K, RAY, Stuart C, LUZURIAGA, Katherine, PERSAUD, Deborah, GREENOUGH, Thomas, MURESAN, Petronella, SANCHEZ-MERINO, Victor, CAREY, Vincent, BROOKS JACKSON, J, ZIEMNIAK, Carrie, FOX, Lawrence, BELZER, Marvin

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Absence of Intact nef Sequences in a Long-Term Survivor with Nonprogressive HIV-1 Infection by Kirchhoff, Frank, Greenough, Thomas C, Brettler, Doreen B, Sullivan, John L, Desrosiers, Ronald C

“…Although disease develops within 10 years in most persons infected with human immunodeficiency virus type 1 (HIV-1), some remain symptom-free for prolonged…”
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Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapy by Greenough, Thomas C, Cunningham, Coleen K, Muresan, Petronella, McManus, Margaret, Persaud, Deborah, Fenton, Terry, Barker, Piers, Gaur, Aditya, Panicali, Dennis, Sullivan, John L, Luzuriaga, Katherine

“…Abstract A trial to evaluate the safety and immunogenicity of recombinant modified vaccinia Ankara (MVA) and fowlpox (FP) vectors expressing multiple HIV-1…”
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CD4 Binding Affinity Determines Human Immunodeficiency Virus Type 1-Induced Alpha Interferon Production in Plasmacytoid Dendritic Cells by HAUPT, Sabrina, DONHAUSER, Norbert, CHAIPAN, Chawaree, SCHUSTER, Philipp, PUFFER, Bridget, DANIELS, Rod S, GREENOUGH, Thomas C, KIRCHHOFF, Frank, SCHMIDT, Barbara

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Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy by Stevenson, Mario, Sharkey, Mark E, Teo, Ian, Greenough, Thomas, Sharova, Natalia, Luzuriaga, Katherine, Sullivan, John L, Bucy, R. Pat, Kostrikis, Leondios G, Haase, Ashley, Veryard, Claire, Davaro, Raul E, Cheeseman, Sarah H, Daly, Jennifer S, Bova, Carol, Ellison, Richard T, Mady, Brian, Lai, Kwan Kew, Moyle, Graeme, Nelson, Mark, Gazzard, Brian, Shaunak, Sunil

“…Treatment of HIV-1-infected individuals with a combination of anti-retroviral agents results in sustained suppression of HIV-1 replication, as evidenced by a…”
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Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes (CTL), Virus Load, and CD4 T Cell Loss: Evidence Supporting a Protective Role for CTL In Vivo by Greenough, Thomas C., Brettler, Doreen B., Somasundaran, Mohan, Panicali, Dennis L., Sullivan, John L.

“…The relationships between primary human immunodeficiency virus type 1 (HIV-1) Gag-specific cytotoxic T lymphocyte (CTL) frequency, virus load, and CD4 T cell…”
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Declining CD4 T-Cell Counts in a Person Infected with nef-Deleted HIV-1 by Desrosiers, Ronald C, Greenough, Thomas C, Sullivan, John L

“…To the Editor: We have recently seen declining CD4 T-lymphocyte counts in a man with long-term, nonprogressive infection with only nef -deleted forms of human…”
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