Search Results - "GREENHAW, J"

Regorafenib impairs mitochondrial functions, activates AMP-activated protein kinase, induces autophagy, and causes rat hepatocyte necrosis by Weng, Zuquan, Luo, Yong, Yang, Xi, Greenhaw, James J, Li, Haibo, Xie, Liming, Mattes, William B, Shi, Qiang

“…Highlights • Regorafenib uncouples hepatic mitochondrial oxidative phosphorylation. • Regorafenib causes necrosis but not apoptosis in hepatocytes. •…”
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Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma by Mattes, W., Davis, K., Fabian, E., Greenhaw, J., Herold, M., Looser, R., Mellert, W., Groeters, S., Marxfeld, H., Moeller, N., Montoya-Parra, G., Prokoudine, A., van Ravenzwaay, B., Strauss, V., Walk, T., Kamp, H.

“…While conventional parameters used to detect hepatotoxicity in drug safety assessment studies are generally informative, the need remains for parameters that…”
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Congenital heart defects and genetic variants in the methylenetetrahydroflate reductase gene by Hobbs, C A, James, S J, Parsian, A, Krakowiak, P A, Jernigan, S, Greenhaw, J J, Lu, Y, Cleves, M A

“…Background: Most non-syndromic congenital heart defects (CHD) are caused by a complex interaction between maternal lifestyle factors, environmental exposures,…”
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Hepatic Transcript Profiles of Cytochrome P450 Genes Predict Sex Differences in Drug Metabolism by Fuscoe, James C, Vijay, Vikrant, Hanig, Joseph P, Han, Tao, Ren, Lijun, Greenhaw, James J, Beger, Richard D, Pence, Lisa M, Shi, Qiang

“…Safety assessments of new drug candidates are an important part of the drug development and approval process. Often, possible sex-associated susceptibilities…”
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Drug-Induced Liver Injury in Children: Clinical Observations, Animal Models, and Regulatory Status by Shi, Qiang, Yang, Xi, Greenhaw, James J., Salminen, Alec Thomas, Russotti, Gary M., Salminen, William F.

“…Drug-induced liver injury in children (cDILI) accounts for about 1% of all reported adverse drug reactions throughout all age groups, less than 10% of all…”
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Metabolic pathways for activation of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine in human lymphoid cells by ROBBINS, B. L, GREENHAW, J, CONNELLY, M. C, FRIDLAND, A

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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Cholate extracts of mitochondrial outer membranes increase inhibition by malonyl-CoA of carnitine palmitoyltransferase-I by a mechanism involving phospholipids by MYNATT, R. L, GREENHAW, J. J, COOK, G. A

“…It has been reported that sodium cholate can separate the catalytic component of carnitine palmitoyltransferase-I (CPT-I) from a putative malonyl-CoA-binding…”
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Effects of in vitro prepared immune complexes on rat adipose tissue lipoprotein lipase by Singh, A, Kang, ES, Greenhaw, J, Dorsett, P

“…The possibility that circulating immune complexes (IC) could modify lipoprotein lipase (LPL) activity or release was explored in in vitro systems. IC were…”
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Novel Resuscitation Strategy for Pulmonary Contusion after Severe Chest Trauma by Kelly, Michael E., Miller, Preston R., Greenhaw, James J., Fabian, Timothy C., Proctor, Kenneth G.

“…BACKGROUND: METHODS: RESULTS:Fluid requirements were reduced by half with Hextend compared with LR (p < 0.05). ATL-146e in either Hextend or LR transiently…”
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Macrophage Cyclooxygenase Expression, Immunosuppression, and Cardiopulmonary Dysfunction after Blunt Chest Trauma by Desselle, Wesley J., Greenhaw, James J., Trenthem, Lisa L., Fabian, Timothy C., Proctor, Kenneth G.

“…BACKGROUNDTwo series of experiments were performed in swine who received severe blunt chest trauma. The goals were to determine the time course of constitutive…”
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Pectoral Glands of Scaphiopus and Megophrys by Jacob, James S., Greenhaw, James J., Plummer, Michael V., Gay, Jo M.

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Congenital heart defects and genetic variants in the methylenetetrahydroflate reductase aene by HOBBS, C. A, JAMES, S. J, PARSIAN, A, KRAKOWIAK, P. A, JERNIGAN, S, GREENHAW, J. J, LU, Y, CLEVES, M. A

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Cellular Phosphorylation of 2′, 3′-Dideoxyadenosine-5′-monophosphate, a Key Intermediate in The Activation of the Antiviral Agent DDI, in Human Peripheral Blood Mononuclear Cells by Robbins, Brian L., Greenhaw, Jack, Fridland, Arnold

“…2′,3′-dideoxyadenosine 5-monophosphate (ddAMP), is a key intermediate in the metabolism of the antiviral agent 2′,3′-dideoxyinosine (ddI) to its active…”
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College counseling center professional staff involvement in professional organizations by Greenhaw, Kimberly J

“…College counselors today face increasing challenges, with fewer resources than in the past. Little has been known as to whether college counselors take…”
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Campus Chaplains: Cult Training and Perceptions by Elleven, Russell K, Greenhaw, Kimberly J, Allen, Jeff

“…This article examines the perception of 43 college chaplains across the United States with regard to cult training and perceptions of college and university…”
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Serum lipolytic activity in Reye's syndrome by Kang, E S, Matsuo, N, Nagai, T, Greenhaw, J, Williams, P L

“…High levels of the serum free fatty acids (FFA) are found in Reye's syndrome (RS). While this is attributed to enhanced adipose tissue lipolysis, the…”
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Total and peroxisomal fatty acid oxidation by liver homogenates from autopsied Reye's and control subjects by Kang, E S, Capaci, M T, Sawhney, B, Greenhaw, J

“…To determine whether the accumulation of liver triglyceride in Reye's syndrome could be due to a block in beta-oxidation of the fatty acids, the ability of…”
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Macrophage cyclooxygenase expression, immunosuppression, and cardiopulmonary dysfunction after blunt chest trauma. Discussion by DESSELLE, Wesley J, GREENHAW, James J, TRENTHEM, Lisa L, FABIAN, Timothy C, PROCTOR, Kenneth G, HAISCH, Carl E, HAUSER, Carl J

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