Search Results - "GREENFEDER, Scott"

Emerging strategies and agents to lower cardiovascular risk by increasing high density lipoprotein cholesterol levels by Greenfeder, Scott

“…For decades, the focus of therapy to mitigate cardiovascular risk has been to lower low density lipoprotein cholesterol (LDL-C), so called "bad cholesterol"…”
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Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice by Stanton, Michaela C, Chen, Shu-Cheng, Jackson, James V, Rojas-Triana, Alberto, Kinsley, David, Cui, Long, Fine, Jay S, Greenfeder, Scott, Bober, Loretta A, Jenh, Chung-Her

“…Obesity and inflammation are highly integrated processes in the pathogenesis of insulin resistance, diabetes, dyslipidemia, and non-alcoholic fatty liver…”
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Identification and characterization of splice variants of the human P2X7 ATP channel by Cheewatrakoolpong, Boonlert, Gilchrest, Helen, Anthes, John C, Greenfeder, Scott

“…The P2X7 channel is a member of the P2X family of ligand-gated ion channels which respond to ATP as the endogenous agonist. Studies suggest that P2X7 has a…”
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Th2 cytokines and asthma. The role of interleukin-5 in allergic eosinophilic disease by Greenfeder, S, Umland, S P, Cuss, F M, Chapman, R W, Egan, R W

“…Interleukin-5 is produced by a number of cell types, and is responsible for the maturation and release of eosinophils in the bone marrow. In humans,…”
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Cloning and pharmacological characterization of mouse TRPV1 by Correll, Craig C., Phelps, P. Tara, Anthes, John C., Umland, Shelby, Greenfeder, Scott

“…The Transient Receptor Potential cation channel V1 (TRPV1) is expressed in peripheral nociceptive neurons and is subject to polymodal activation via various…”
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Biochemical characterization of desloratadine, a potent antagonist of the human histamine H1 receptor by ANTHES, John C, GILCHREST, Helen, EGAN, Robert W, RICHARD, Christian, ECKEL, Stephen, HESK, Dave, WEST, Robert E, WILLIAMS, Shirley M, GREENFEDER, Scott, BILLAH, Motasim, KREUTNER, William

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Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia by Palani, Anandan, Rao, Ashwin U, Chen, Xiao, Huang, Xianhai, Su, Jing, Tang, Haiqun, Huang, Ying, Qin, Jun, Xiao, Dong, Degrado, Sylvia, Sofolarides, Michael, Zhu, Xiaohong, Liu, Zhidan, McKittrick, Brian, Zhou, Wei, Aslanian, Robert, Greenlee, William J, Senior, Mary, Cheewatrakoolpong, Boonlert, Zhang, Hongtao, Farley, Constance, Cook, John, Kurowski, Stan, Li, Qiu, van Heek, Margaret, Wang, Gangfeng, Hsieh, Yunsheng, Li, Fangbiao, Greenfeder, Scott, Chintala, Madhu

“…Structure-guided optimization of a series of C-5 alkyl substituents led to the discovery of a potent nicotinic acid receptor agonist SCH 900271 (33) with an…”
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Cloning and characterization of the hamster and guinea pig nicotinic acid receptors by Torhan, April Smith, Cheewatrakoolpong, Boonlert, Kwee, Lia, Greenfeder, Scott

“…In this study, we present the identification and characterization of hamster and guinea pig nicotinic acid receptors. The hamster receptor shares ∼80–90%…”
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Cloning and characterization of a novel human histamine receptor by Morse, K L, Behan, J, Laz, T M, West, Jr, R E, Greenfeder, S A, Anthes, J C, Umland, S, Wan, Y, Hipkin, R W, Gonsiorek, W, Shin, N, Gustafson, E L, Qiao, X, Wang, S, Hedrick, J A, Greene, J, Bayne, M, Monsma, Jr, F J

“…Histamine exerts its numerous physiological functions through interaction with G protein-coupled receptors. Three such receptors have been defined at both the…”
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Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex by Greenfeder, Scott A., Nunes, Perla, Kwee, Lia, Labow, Mark, Chizzonite, Richard A., Ju, Grace

“…A monoclonal antibody (mAb) was isolated that blocked the binding and bioactivity of both human and murine interleukin 1β (IL-1β) on murine IL-1…”
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A Review and Comparative Case Study Analysis of Real-World Evidence in European Regulatory and Health Technology Assessment Decision Making for Oncology Medicines by Zong, Jihong, Rojubally, Adina, Pan, Xiaoyun, Wolf, Birgit, Greenfeder, Scott, Upton, Alexander, Gdovin Bergeson, Joette

“…Real-world evidence (RWE) is valuable in supporting regulatory and health technology assessment (HTA) decisions; however, the actual contribution to approvals…”
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SCH 206272: a potent, orally active tachykinin NK1, NK2, and NK3 receptor antagonist by ANTHES, John C, CHAPMAN, Richard W, RIZZO, Charles, CRAWLEY, Yvette, SHIH, Neng-Yang, PIWINSKI, John, REICHARD, Greg, TING, Pauline, CARRUTHERS, Nick, CUSS, Francis M, BILLAH, Motasim, KREUTNER, William, RICHARD, Christian, EGAN, Robert W, ECKEL, Stephen, CORBOZ, Michel, HEY, John A, FERNANDEZ, Xiomara, GREENFEDER, Scott, MCLEOD, Robbie, SEHRING, Susan

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A Review and Comparative Case Study Analysis of Real-world Evidence in European Regulatory and HTA Decision-making for Oncology Medicines by Zong, Jihong, Rojubally, Adina, Pan, Xiaoyun, Wolf, Birgit, Greenfeder, Scott, Upton, Alexander, Bergeson, Joette Gdovin

“…Real-world evidence (RWE) is valuable in supporting regulatory and HTA decisions, however, the actual contribution in approvals remains elusive. This study…”
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Tryptase-induced airway microvascular leakage in guinea pigs: involvement of tachykinins and leukotrienes by Greenfeder, Scott, Sehring, Susan, McHugh, Nansie, Corboz, Michel, Rivelli, Maria, Anthes, John C, Billah, Motasim, Egan, Robert W, Chapman, Richard W

“…Tryptase, a serine protease synthesized by and stored in mast cells, is implicated as an important mediator in the pathogenesis of airway inflammation. In this…”
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Neuromodulation mediated by the tachykinin NK 3 -receptor agonist [MePhe 7 ]-neurokinin B in the isolated perfused lung of nonsensitized nonchallenged and ovalbumin-sensitized and -challenged guinea pig by Corboz, Michel R., Rivelli, Maria A., Fernandez, Xiomara, Greenfeder, Scott

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New strategies for the development of lipid-lowering therapies to reduce cardiovascular risk by Graham, Ian, Shear, Chuck, De Graeff, Pieter, Boulton, Caroline, Catapano, Alberico L, Stough, Wendy Gattis, Carlsson, Stefan C, De Backer, Guy, Emmerich, Joseph, Greenfeder, Scott, Kim, Albert M, Lautsch, Dominik, Nguyen, Tu, Nissen, Steven E, Prasad, Krishna, Ray, Kausik K, Robinson, Jennifer G, Sasiela, William J, Bruins Slot, Karsten, Stroes, Erik, Thuren, Tom, Van der Schueren, Bart, Velkovski-Rouyer, Maja, Wasserman, Scott M, Wiklund, Olov, Zouridakis, Emmanouil

“…Abstract The very high occurrence of cardiovascular events presents a major public health issue, because treatment remains suboptimal. Lowering LDL cholesterol…”
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Neuromodulation mediated by the tachykinin NK3-receptor agonist [MePhe7]-neurokinin B in the isolated perfused lung of nonsensitized nonchallenged and ovalbumin-sensitized and -challenged guinea pig by Corboz, Michel R., Rivelli, Maria A., Fernandez, Xiomara, Greenfeder, Scott

“…The neuromodulatory action of the tachykinin NK3-receptor agonist [MePhe7]-neurokinin B ([MePhe7]-NKB) was evaluated on vagal stimulation-induced…”
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Biochemical characterization of desloratadine, a potent antagonist of the human histamine H 1 receptor by Anthes, John C, Gilchrest, Helen, Richard, Christian, Eckel, Stephen, Hesk, Dave, West, Robert E, Williams, Shirley M, Greenfeder, Scott, Billah, Motasim, Kreutner, William, Egan, Robert W

“…We have characterized desloratadine (5 H-benzo[5,6]cyclohepta[1,2- b]pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene), CAS 100643-71-8) as a potent…”
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SAR studies of C2 ethers of 2H-pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-triones as nicotinic acid receptor (NAR) agonist by Huang, Xianhai, Su, Jing, Rao, Ashwin U., Tang, Haiqun, Zhou, Wei, Zhu, Xiaohong, Chen, Xiao, Liu, Zhidan, Huang, Ying, Degrado, Sylvia, Xiao, Dong, Qin, Jun, Aslanian, Robert, McKittrick, Brian A., Greenfeder, Scott, Heek, Margaret van, Chintala, Madhu, Palani, Anandan

“…Based on in house screening lead compound 1 for the NAR project, SAR studies have been focused on the modification of the C2 ethers of the pyrimidinedione core…”
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Corrigendum to “Identification and characterization of splice variants of the human P2X7 ATP channel” [Biochem. Biophys. Res. Commun. 332 (2005) 17–27] by Cheewatrakoolpong, Boonlert, Gilchrest, Helen, Anthes, John C., Greenfeder, Scott

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