Search Results - "GREENER, Ian D"

Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar by Kelemen, Kamilla, Greener, Ian D., Wan, Xiaoping, Parajuli, Shankar, Donahue, J. Kevin

“…Arrhythmias originating in scarred ventricular myocardium are a major cause of death, but the underlying mechanism allowing these rhythms to exist remains…”
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Connexin Gene Transfer Preserves Conduction Velocity and Prevents Atrial Fibrillation by IGARASHI, Tomonori, FINET, J. Emanuel, TAKEUCHI, Ayano, FUJINO, Yoshihisa, STROM, Maria, GREENER, Ian D, ROSENBAUM, David S, DONAHUE, J. Kevin

“…Several lines of evidence have suggested that maintenance of atrial fibrillation (AF) depends on reentrant mechanisms. Maintenance of reentry necessitates a…”
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Connexin43 Gene Transfer Reduces Ventricular Tachycardia Susceptibility After Myocardial Infarction by Greener, Ian D., PhD, Sasano, Tetsuo, MD, PhD, Wan, Xiaoping, PhD, Igarashi, Tomonori, MD, PhD, Strom, Maria, PhD, Rosenbaum, David S., MD, Donahue, J. Kevin, MD

“…Objectives The aim of this study was to evaluate the links between connexin43 (Cx43) expression, myocardial conduction velocity, and ventricular tachycardia in…”
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Selective Molecular Potassium Channel Blockade Prevents Atrial Fibrillation by AMIT, Guy, KIKUCHI, Kan, GREENER, Ian D, LIZHU YANG, NOVACK, Victor, DONAHUE, J. Kevin

“…Safety and efficacy limit currently available atrial fibrillation (AF) therapies. We hypothesized that atrial gene transfer would allow focal manipulation of…”
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c-Src Kinase Inhibition Reduces Arrhythmia Inducibility and Connexin43 Dysregulation After Myocardial Infarction by Rutledge, Cody A., BS, Ng, Fu Siong, MD, PhD, Sulkin, Matthew S., MS, Greener, Ian D., PhD, Sergeyenko, Artem M., BA, Liu, Hong, MD, PhD, Gemel, Joanna, PhD, Beyer, Eric C., MD, PhD, Sovari, Ali A., MD, Efimov, Igor R., PhD, Dudley, Samuel C., MD, PhD

“…Objectives The aim of this study was to evaluate the role of tyrosine kinase cellular-Src (c-Src) inhibition on connexin43 (Cx43) regulation in a mouse model…”
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Differential Expression of Ion Channel Transcripts in Atrial Muscle and Sinoatrial Node in Rabbit by Tellez, James O, Dobrzynski, Halina, Greener, Ian D, Graham, Gillian M, Laing, Emma, Honjo, Haruo, Hubbard, Simon J, Boyett, Mark R, Billeter, Rudi

“…The aim of the study was to identify ion channel transcripts expressed in the sinoatrial node (SAN), the pacemaker of the heart. Functionally, the SAN can be…”
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Computer Three-Dimensional Reconstruction of the Atrioventricular Node by Li, Jue, Greener, Ian D, Inada, Shin, Nikolski, Vladimir P, Yamamoto, Mitsuru, Hancox, Jules C, Zhang, Henggui, Billeter, Rudi, Efimov, Igor R, Dobrzynski, Halina, Boyett, Mark R

“…Because of its complexity, the atrioventricular node (AVN), remains 1 of the least understood regions of the heart. The aim of the study was to construct a…”
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Site of Origin and Molecular Substrate of Atrioventricular Junctional Rhythm in the Rabbit Heart by Dobrzynski, Halina, Nikolski, Vladimir P, Sambelashvili, Alexandre T, Greener, Ian D, Yamamoto, Mitsuru, Boyett, Mark R, Efimov, Igor R

“…ABSTRACT—During failure of the sinoatrial node, the heart can be driven by an atrioventricular (AV) junctional pacemaker. The position of the leading pacemaker…”
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Ventricular tachycardia from the healed myocardial infarction scar: Validation of an animal model and utility of gene therapy by Sasano, Tetsuo, MD, Kelemen, Kamilla, MD, Greener, Ian D., PhD, Donahue, J. Kevin, MD

“…Life-threatening ventricular arrhythmias generally occur in the setting of structural heart disease. Current clinical options for patients at risk for these…”
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P2 purinergic receptor mRNA in rat and human sinoatrial node and other heart regions by Musa, Hanny, Tellez, James O., Chandler, Natalie J., Greener, Ian D., Mączewski, Michał, Mackiewicz, Urszula, Beresewicz, Andrzej, Molenaar, Peter, Boyett, Mark R., Dobrzynski, Halina

“…It is known that adenosine 5′-triphosphate (ATP) is a cotransmitter in the heart. Additionally, ATP is released from ischemic and hypoxic myocytes. Therefore,…”
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Ion Channel Transcript Expression at the Rabbit Atrioventricular Conduction Axis by Greener, Ian D, Tellez, James O, Dobrzynski, Halina, Yamamoto, Mitsuru, Graham, Gillian M, Billeter, Rudi, Boyett, Mark R

“…BACKGROUND—Little is known about the distribution of gap junctions and ion channels in the atrioventricular node, even though the physiology and pathology of…”
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Molecular Architecture of the Human Sinus Node : Insights Into the Function of the Cardiac Pacemaker by CHANDLER, Natalie J, GREENER, Ian D, BILLETER, Rudolf, SHARMA, Vinod, SIGG, Daniel C, BOYETT, Mark R, DOBRZYNSKI, Halina, TELLEZ, James O, INADA, Shin, MUSA, Hanny, MOLENAAR, Peter, DIFRANCESCO, Dario, BARUSCOTTI, Mirko, LONGHI, Renato, ANDERSON, Robert H

“…Although we know much about the molecular makeup of the sinus node (SN) in small mammals, little is known about it in humans. The aims of the present study…”
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Connexin Gene Transfer Preserves Conduction Velocity and Prevents Atrial Fibrillation by Igarashi, Tomonori, Finet, J. Emanuel, Strom, Maria, D. Greener, Ian, S. Rosenbaum, David, Donahue, J. Kevin

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Structure‐function relationship in the AV junction by Efimov, Igor R., Nikolski, Vladimir P., Rothenberg, Florence, Greener, Ian D., Li, Jue, Dobrzynski, Halina, Boyett, Mark

“…In the normal heart, the atrioventricular node (AVN) is part of the sole pathway between the atria and ventricles. Under normal physiological conditions, the…”
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Abstract 18802: Endothelial-Mesenchymal Transition (EndMT) of the Atrial Endocardial Endothelial Layer: A Potential Contributor to Atrial Pathological Remodeling? by Greener, Ian D, Rutledge, Cody A, Dudley, Samuel C

“…Abstract only Introduction: Atrial fibrosis is a major contributor to the atrial fibrillation substrate but the mechanisms underlying its formation remain…”
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