Search Results - "GRAZIA CASCIO, Maria"

Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors by Marini, Pietro, Cascio, Maria‐Grazia, King, Angela, Pertwee, Roger G, Ross, Ruth A

“…Background and Purpose Although cannabinoid CB2 receptor ligands have been widely characterized in recombinant systems in vitro, little pharmacological…”
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Gradient of 2-Arachidonoylglycerol Regulates Mouse Epididymal Sperm Cell Start-Up by Cobellis, Gilda, Ricci, Giulia, Cacciola, Giovanna, Orlando, Pierangelo, Petrosino, Stefania, Cascio, Maria Grazia, Bisogno, Tiziana, De Petrocellis, Luciano, Chioccarelli, Teresa, Altucci, Lucia, Fasano, Silvia, Meccariello, Rosaria, Pierantoni, Riccardo, Ledent, Catherine, Di Marzo, Vincenzo

“…During transit through the epididymis, spermatozoa are normally kept immotile and do not attain the ability to become motile until they reach the caudal…”
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Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine by González, Sara, Grazia Cascio, Maria, Fernández-Ruiz, Javier, Fezza, Filomena, Di Marzo, Vincenzo, Ramos, José A

“…Despite recent data suggesting that the endocannabinoid transmission is a component of the brain reward system and plays a role in dependence/withdrawal to…”
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Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: A critical revisitation by Ortar, Giorgio, Cascio, Maria Grazia, Moriello, Aniello Schiano, Camalli, Mercedes, Morera, Enrico, Nalli, Marianna, Di Marzo, Vincenzo

“…We have synthesized a series of 18 1,5- and 2,5-disubstituted carbamoyl tetrazoles, including LY2183240 ( 1) and LY2318912 ( 7), two compounds previously…”
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New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists by MANERA, Clementina, GRAZIA CASCIO, Maria, LUIGI FERRARINI, Pier, BENETTI, Veronica, ALLARA, Marco, TUCCINARDI, Tiziano, MARTINELLI, Adriano, SACCOMANNI, Giuseppe, VIVOLI, Elisa, GHELARDINI, Carla, DI MARZO, Vincenzo

“…A series of new 1,8-naphthyridine and quinoline derivatives were synthesized and evaluated for their cannabinoid receptor affinity. In particular, compounds 2,…”
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Novel sterically hindered cannabinoid CB1 receptor ligands by URBANI, Paolo, GRAZIA CASCIO, Maria, RAMUNNO, Anna, BISOGNO, Tiziana, SATURNINO, Carmela, DI MARZO, Vincenzo

“…In the present study, 11 novel N-(3,3-diphenyl)propyl-2,2-diphenylacetamide derivatives (4a-d and 9a-g) and six triphenylacetamides (10a-c and 11a-c) were…”
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A structure–activity relationship study on N-arachidonoyl-amino acids as possible endogenous inhibitors of fatty acid amide hydrolase by Grazia Cascio, Maria, Minassi, Alberto, Ligresti, Alessia, Appendino, Giovanni, Burstein, Sumner, Di Marzo, Vincenzo

“…N-arachidonoyl-glycine (NAGly) has been recently identified in rodent tissues and found to exhibit analgesic activity in vivo. NAGly is a potent inhibitor of…”
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Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors by Brizzi, Antonella, Cascio, Maria Grazia, Brizzi, Vittorio, Bisogno, Tiziana, Dinatolo, Maria Teresa, Martinelli, Adriano, Tuccinardi, Tiziano, Di Marzo, Vincenzo

“…In our ongoing program aimed at the design, synthesis, and biological evaluation of novel cannabinoid receptor ligands derived from olivetol and…”
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Cloning of the First sn1-DAG Lipases Points to the Spatial and Temporal Regulation of Endocannabinoid Signaling in the Brain by Bisogno, Tiziana, Howell, Fiona, Williams, Gareth, Minassi, Alberto, Cascio, Maria Grazia, Ligresti, Alessia, Matias, Isabel, Schiano-Moriello, Aniello, Paul, Praveen, Williams, Emma-Jane, Gangadharan, Uma, Hobbs, Carl, Di Marzo, Vincenzo, Doherty, Patrick

“…Diacylglycerol (DAG) lipase activity is required for axonal growth during development and for retrograde synaptic signaling at mature synapses. This enzyme…”
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CB1 Cannabinoid Receptors and On-Demand Defense against Excitotoxicity by Marsicano, Giovanni, Goodenough, Sharon, Monory, Krisztina, Hermann, Heike, Eder, Matthias, Cannich, Astrid, Azad, Shahnaz C., Cascio, Maria Grazia, Gutiérrez, Silvia Ortega, van der Stelt, Mario, López-Rodríguez, Maria Luz, Casanova, Emilio, Schütz, Günther, Zieglgänsberger, Walter, Di Marzo, Vincenzo, Behl, Christian, Lutz, Beat

“…Abnormally high spiking activity can damage neurons. Signaling systems to protect neurons from the consequences of abnormal discharge activity have been…”
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Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors by Pasquini, Serena, De Rosa, Maria, Ligresti, Alessia, Mugnaini, Claudia, Brizzi, Antonella, Caradonna, Nicola P., Cascio, Maria Grazia, Bolognini, Daniele, Pertwee, Roger G., Di Marzo, Vincenzo, Corelli, Federico

“…Within our studies on structure–activity relationships of 4-quinolone-3-carboxamides as cannabinoid ligands, a new series of compounds characterized by a…”
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1,2,3-Triazole Ring as a Peptido- and Olefinomimetic Element: Discovery of Click Vanilloids and Cannabinoids by Appendino, Giovanni, Bacchiega, Sara, Minassi, Alberto, Cascio, Maria Grazia, De Petrocellis, Luciano, Di Marzo, Vincenzo

“…Fooling nature: The replacement of amide and alkene groups in a biological setting with the 1,2,3‐triazole group led to the discovery of compounds with a…”
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New N-Arachidonoylserotonin Analogues with Potential “Dual” Mechanism of Action against Pain by Ortar, Giorgio, Cascio, Maria Grazia, De Petrocellis, Luciano, Morera, Enrico, Rossi, Francesca, Schiano-Moriello, Aniello, Nalli, Marianna, de Novellis, Vito, Woodward, David F, Maione, Sabatino, Di Marzo, Vincenzo

“…N-Arachidonoylserotonin (AA-5-HT, 1a) is an inhibitor of fatty acid amide hydrolase (FAAH) that acts also as an antagonist of transient receptor potential…”
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Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 3. Synthesis, Structure−Affinity Relationships, and Pharmacological Characterization of 6-Substituted 4-Quinolone-3-carboxamides as Highly Selective Cannabinoid-2 Receptor Ligands by Pasquini, Serena, Ligresti, Alessia, Mugnaini, Claudia, Semeraro, Teresa, Cicione, Lavinia, De Rosa, Maria, Guida, Francesca, Luongo, Livio, De Chiaro, Maria, Cascio, Maria Grazia, Bolognini, Daniele, Marini, Pietro, Pertwee, Roger, Maione, Sabatino, Marzo, Vincenzo Di, Corelli, Federico

“…A set of quinolone-3-carboxamides 2 bearing diverse substituents at position 1, 3, and 6 of the bicyclic nucleus was prepared. Except for six compounds…”
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Rational Design, Synthesis, and Pharmacological Properties of New 1,8-Naphthyridin-2(1H)-on-3-Carboxamide Derivatives as Highly Selective Cannabinoid-2 Receptor Agonists by Manera, Clementina, Saccomanni, Giuseppe, Adinolfi, Barbara, Benetti, Veronica, Ligresti, Alessia, Cascio, Maria Grazia, Tuccinardi, Tiziano, Lucchesi, Valentina, Martinelli, Adriano, Nieri, Paola, Masini, Emanuela, Di Marzo, Vincenzo, Ferrarini, Pier Luigi

“…The CB2 receptor activation can be exploited for the treatment of diseases such as chronic pain and tumors of immune origin, devoid of psychotropic activity…”
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Development of the first potent and specific inhibitors of endocannabinoid biosynthesis by Bisogno, Tiziana, Cascio, Maria Grazia, Saha, Bijali, Mahadevan, Anu, Urbani, Paolo, Minassi, Alberto, Appendino, Giovanni, Saturnino, Carmela, Martin, Billy, Razdan, Raj, Di Marzo, Vincenzo

“…Enzymes for the biosynthesis and degradation of the endocannabinoid 2-arachidonoyl glycerol (2-AG) have been cloned and are the sn-1-selective-diacylglycerol…”
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Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB1 receptor antagonist by Wiley, Jenny L., Breivogel, Christopher S., Mahadevan, Anu, Pertwee, Roger G., Cascio, Maria Grazia, Bolognini, Daniele, Huffman, John W., Walentiny, D. Matthew, Vann, Robert E., Razdan, Raj K., Martin, Billy R.

“…Rimonabant, the prototypic antagonist of cannabinoid CB1 receptors, has been reported to have inverse agonist properties at higher concentrations, which may…”
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Changes in endocannabinoid levels in a rat model of behavioural sensitization to morphine by Viganò, Daniela, Valenti, Marta, Grazia Cascio, Maria, Di Marzo, Vincenzo, Parolaro, Daniela, Rubino, Tiziana

“…The opioid and cannabinoid systems co‐operate to regulate physiological processes such as nociception and reward. The endocannabinoid system may be a component…”
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New tetrazole-based selective anandamide uptake inhibitors by Ortar, Giorgio, Schiano Moriello, Aniello, Cascio, Maria Grazia, De Petrocellis, Luciano, Ligresti, Alessia, Morera, Enrico, Nalli, Marianna, Di Marzo, Vincenzo

“…A new series of 1,5-and 2,5-disubstituted tetrazoles have been synthesized and evaluated as inhibitors of anandamide cellular uptake. Some of them inhibit the…”
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New Resorcinol−Anandamide “Hybrids” as Potent Cannabinoid Receptor Ligands Endowed with Antinociceptive Activity in Vivo by Brizzi, Antonella, Brizzi, Vittorio, Cascio, Maria Grazia, Corelli, Federico, Guida, Francesca, Ligresti, Alessia, Maione, Sabatino, Martinelli, Adriano, Pasquini, Serena, Tuccinardi, Tiziano, Di Marzo, Vincenzo

“…Bearing in mind the pharmacophoric requirements of both (−)-trans-Δ9-tetrahydrocannabinol (THC) and anandamide (AEA), we designed a novel pharmacophore…”
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