Search Results - "GRAY, W"

Mosaic nature of the mitochondrial proteome: Implications for the origin and evolution of mitochondria by Gray, Michael W

“…Comparative studies of the mitochondrial proteome have identified a conserved core of proteins descended from the α-proteobacterial endosymbiont that gave…”
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Control of Invasion by Epithelial-to-Mesenchymal Transition Programs during Metastasis by Pearson, Gray W

“…Epithelial-to-mesenchymal transition (EMT) programs contribute to the acquisition of invasive properties that are essential for metastasis. It is well…”
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Mitochondrial evolution by Gray, Michael W

“…Viewed through the lens of the genome it contains, the mitochondrion is of unquestioned bacterial ancestry, originating from within the bacterial phylum…”
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How Machine Learning Will Transform Biomedicine by Goecks, Jeremy, Jalili, Vahid, Heiser, Laura M., Gray, Joe W.

“…This Perspective explores the application of machine learning toward improved diagnosis and treatment. We outline a vision for how machine learning can…”
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7-Ketocholesterol in disease and aging by Anderson, Amelia, Campo, Angielyn, Fulton, Elena, Corwin, Anne, Jerome, 3rd, W Gray, O'Connor, Matthew S

“…7-Ketocholesterol (7KC) is a toxic oxysterol that is associated with many diseases and disabilities of aging, as well as several orphan diseases. 7KC is the…”
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Dysfunctional High-Density Lipoprotein in Patients on Chronic Hemodialysis by Yamamoto, Suguru, MD, PhD, Yancey, Patricia G., PhD, Ikizler, T. Alp, MD, Jerome, W. Gray, PhD, Kaseda, Ryohei, MD, PhD, Cox, Brian, PhD, Bian, Aihua, MPH, Shintani, Ayumi, PhD, MPH, Fogo, Agnes B., MD, Linton, MacRae F., MD, Fazio, Sergio, MD, PhD, Kon, Valentina, MD

“…Objectives This study examined the functionality of high-density lipoprotein (HDL) in individuals with end-stage renal disease on dialysis (ESRD-HD)…”
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Circulating tumor DNA as an early cancer detection tool by Campos-Carrillo, Andrea, Weitzel, Jeffrey N., Sahoo, Prativa, Rockne, Russell, Mokhnatkin, Janet V., Murtaza, Muhammed, Gray, Stacy W., Goetz, Laura, Goel, Ajay, Schork, Nicholas, Slavin, Thomas P.

“…Circulating tumor DNA holds substantial promise as an early detection biomarker, particularly for cancers that do not have currently accepted screening…”
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Tumor-Derived Cell Lines as Molecular Models of Cancer Pharmacogenomics by Goodspeed, Andrew, Heiser, Laura M, Gray, Joe W, Costello, James C

“…Compared with normal cells, tumor cells have undergone an array of genetic and epigenetic alterations. Often, these changes underlie cancer development,…”
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Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target by Timmerman, Luika A., Holton, Thomas, Yuneva, Mariia, Louie, Raymond J., Padró, Mercè, Daemen, Anneleen, Hu, Min, Chan, Denise A., Ethier, Stephen P., van ‘t Veer, Laura J., Polyak, Kornelia, McCormick, Frank, Gray, Joe W.

“…A handful of tumor-derived cell lines form the mainstay of cancer therapeutic development, yielding drugs with an impact typically measured as months to…”
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Catastrophic Cooling in Superwinds. III. Nonequilibrium Photoionization by Danehkar, A., Oey, M. S., Gray, W. J.

“…Abstract Observations of some starburst-driven galactic superwinds suggest that strong radiative cooling could play a key role in the nature of feedback and…”
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Revisiting Oxygen‐18 and Clumped Isotopes in Planktic and Benthic Foraminifera by Daëron, M, Gray, W R

“…Abstract Foraminiferal isotopes are widely used to study past oceans, with different species recording conditions at different depths. Their δ 18 O values…”
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Metrics other than potency reveal systematic variation in responses to cancer drugs by Fallahi-Sichani, Mohammad, Honarnejad, Saman, Heiser, Laura M, Gray, Joe W, Sorger, Peter K

“…IC 50 values are widely used measures of compound potency. A multiparametric analysis of dose-response curves derived from a panel of cell lines treated with…”
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2-Hydroxypropyl-gamma-cyclodextrin overcomes NPC1 deficiency by enhancing lysosome-ER association and autophagy by Singhal, Ashutosh, Krystofiak, Evan S., Jerome, W. Gray, Song, Byeongwoon

“…Niemann-Pick type C (NPC) disease is a fatal neurodegenerative disorder caused by mutations in NPC1 and NPC2 genes that result in an accumulation of…”
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Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas' disease drug discovery by MacLean, Lorna M, Thomas, John, Lewis, Michael D, Cotillo, Ignacio, Gray, David W, De Rycker, Manu

“…Chagas' disease is responsible for significant mortality and morbidity in Latin America. Current treatments display variable efficacy and have adverse side…”
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Ocean Acidification Has Multiple Modes of Action on Bivalve Larvae by Waldbusser, George G, Hales, Burke, Langdon, Chris J, Haley, Brian A, Schrader, Paul, Brunner, Elizabeth L, Gray, Matthew W, Miller, Cale A, Gimenez, Iria, Hutchinson, Greg

“…Ocean acidification (OA) is altering the chemistry of the world's oceans at rates unparalleled in the past roughly 1 million years. Understanding the impacts…”
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Global biogeography of ant social parasites: Exploring patterns and mechanisms of an inverse latitudinal diversity gradient by Gray, Kyle W., Rabeling, Christian

“…Aim One of the most consistent global biogeographic patterns is the latitudinal diversity gradient where species richness peaks within the equatorial tropics…”
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Saturation-state sensitivity of marine bivalve larvae to ocean acidification by Waldbusser, George G., Hales, Burke, Langdon, Chris J., Haley, Brian A., Schrader, Paul, Brunner, Elizabeth L., Gray, Matthew W., Miller, Cale A., Gimenez, Iria

“…Ocean acidification results in co-varying inorganic carbon system variables. Of these, an explicit focus on pH and organismal acid–base regulation has failed…”
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An epigenetically distinct breast cancer cell subpopulation promotes collective invasion by Westcott, Jill M, Prechtl, Amanda M, Maine, Erin A, Dang, Tuyen T, Esparza, Matthew A, Sun, Han, Zhou, Yunyun, Xie, Yang, Pearson, Gray W

“…Tumor cells can engage in a process called collective invasion, in which cohesive groups of cells invade through interstitial tissue. Here, we identified an…”
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Development of a nanoparticle-based immunotherapy targeting PD-L1 and PLK1 for lung cancer treatment by Reda, Moataz, Ngamcherdtrakul, Worapol, Nelson, Molly A., Siriwon, Natnaree, Wang, Ruijie, Zaidan, Husam Y., Bejan, Daniel S., Reda, Sherif, Hoang, Ngoc Ha, Crumrine, Noah A., Rehwaldt, Justin P. C., Bindal, Akash, Mills, Gordon B., Gray, Joe W., Yantasee, Wassana

“…Immune checkpoint inhibitors (ICIs) targeting PD-L1 and PD-1 have improved survival in a subset of patients with advanced non-small cell lung cancer (NSCLC)…”
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The pre-endosymbiont hypothesis: a new perspective on the origin and evolution of mitochondria by Gray, Michael W

“…Mitochondrial DNA (mtDNA) is unquestionably the remnant of an α-proteobacterial genome, yet only ~10%-20% of mitochondrial proteins are demonstrably…”
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