Search Results - "GRAY, T. J. B"

Creatine metabolism in the seminiferous epithelium of rats. I. Creatine synthesis by isolated and cultured cells by Moore, N P, Gray, T J, Timbrell, J A

“…The testis synthesizes creatine from both arginine and glycine precursors, but when rat testicular tissue is separated into seminiferous tubules and…”
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Creatine metabolism in the seminiferous epithelium of rats. II. Effect of modulators of cellular biochemical function on creatine secretion by cultured Sertoli cells by Moore, N P, Gray, T J, Timbrell, J A

“…The Sertoli cells have been identified as the primary locus for creatine synthesis within the seminiferous epithelium. The purpose of the studies reported here…”
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Effects of di-(2-ethylhexyl) phthalate and five of its metabolites on rat testis in vivo and in in vitro by Sjöberg, P, Bondesson, U, Gray, T J, Plöen, L

“…In an attempt to establish which compound or compounds are responsible for the testicular damage observed after administration of di-(2-ethylhexyl) phthalate…”
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A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro by OGG, M. S.

“…1. A plasmid containing 1 kb of the CYP3A4 regulatory (promoter) region coupled to a reporter gene for secretary placental alkaline phosphatase (SPAP) was…”
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The peroxisome proliferators are hepatocyte mitogens in chemically-defined media : glucocorticoid-induced PPARα is linked to peroxisome proliferator mitogenesis by PLANT, N. J, HORLEY, N. J, SAVORY, R. L, ELCOMBE, C. R, GRAY, T. J. B, BELL, D. R

“…Peroxisome proliferator-induced mitogenesis is believed to play a role in hepatocarcinogenesis, but it has not been possible to demonstrate high level…”
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Interaction with the Aromatic Hydrocarbon Receptor, CYP1A Induction, and Mutagenicity of a Series of Diaminotoluenes: Implications for Their Carcinogenicity by Cheung, Yen-Ling, Snelling, Jacqueline, Mohammed, N.N.D., Gray, Tim J.B., Ioannides, Costas

“…The present study was undertaken to provide a rationale for the marked difference in carcinogenic potential among isomeric diaminotoluenes, in relation to…”
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Comparative studies on nafenopin-induced hepatic peroxisome proliferation in the rat, Syrian hamster, guinea pig, and marmoset by Lake, B G, Evans, J G, Gray, T J, Körösi, S A, North, C J

“…Nafenopin was administered orally for 21 days to male Sprague-Dawley rats (0.5-50 mg/kg/day), Syrian hamsters (5-250 mg/kg/day), Dunkin-Hartley guinea pigs (50…”
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The murine local lymph node assay: results of an inter-laboratory trial by Kimber, I, Hilton, J, Botham, P A, Basketter, D A, Scholes, E W, Miller, K, Robbins, M C, Harrison, P T, Gray, T J, Waite, S J

“…The local lymph node assay is a novel predictive test for the identification of contact allergens. The collaborative study reported here was performed to…”
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Mutagenicity of chrysene, its methyl and benzo derivatives, and their interactions with cytochromes P-450 and the Ah-receptor; relevance to their carcinogenic potency by Cheung, Y L, Gray, T J, Ioannides, C

“…The genotoxicity in the Ames test of chrysene, of its six methyl and of two benzo-derivatives, and their ability to induce rat hepatic CYP1A and epoxide…”
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Diaminonaphthalenes and related aminocompounds: Mutagenicity, CYP1A induction and interaction with the Ah receptor by Cheung, Yen-ling, Lewis, David F.V., Ridd, T.Ian, Gray, Timothy J.B., Ioannides, Costas

“…Using 1- and 2-aminonaphthalene as model substrates, we investigated the effect of insertion of a second amino group on mutagenicity, binding to the cytosolic…”
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Studies on the mechanism of coumarin-induced toxicity in rat hepatocytes: comparison with dihydrocoumarin and other coumarin metabolites by Lake, B G, Gray, T J, Evans, J G, Lewis, D F, Beamand, J A, Hue, K L

“…Single doses of coumarin (125 mg/kg, ip) produced a depletion of hepatic nonprotein sulfhydryl groups (mainly reduced glutathione; GSH) in young male…”
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Mutagenicity and CYP1A induction by azobenzenes correlates with their carcinogenicity by Cheung, Y L, Puddicombe, S M, Gray, T J, Ioannides, C

“…The genotoxicity of six azobenzenes was evaluated in the Ames test, in the presence of an activation system derived from Aroclor 1254-treated rats. Moreover,…”
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Development of an in vitro reporter gene assay to assess xenobiotic induction of the human CYP3A4 gene by Ogg, M S, Gray, T J, Gibson, G G

“…The current work concerns the development and validation of an in vitro reporter gene assay system for the assessment of induction of human CYP3A4. A plasmid…”
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The mutagenicity and interactions of 2- and 4-(acetylamino)fluorene with cytochrome P450 and the aromatic hydrocarbon receptor may explain the difference in their carcinogenic potency by Ioannides, Costas, Cheung, Yen Ling, Wilson, Judith, Lewis, David F. V, Gray, Tim J. B

“…A study has been undertaken to identify the properties of 2-(acetylamino)fluorene which render it carcinogenic, in contrast to the 4-isomer, the carcinogenic…”
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Rat renal cortical slices: Maintenance of viability and use in in vitro nephrotoxicity testing by Blackmore, M., Richardson, J.C., Rhodes, S.A., Patterson, L., Spencer, A.J., Gray, T.J.B.

“…The majority of in vitro toxicology studies employing precision-cut rat renal slices are carried out using simple incubation systems over relatively short…”
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Comparative hypolipidaemic and peroxisomal effects of ciprofibrate, clofibric acid, and their respective difluorocyclopropyl and 4-fluoro-substituted analogues in rat by Graham, M J, Winham, M A, Old, S L, Gray, T J

“…1. We investigated the biological activity of the difluoro analogue (WIN 36117) of ciprofibrate, a potent peroxisome proliferator, and re-examined the relative…”
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Effect of prolonged administration of clofibric acid and di-(2-ethylhexyl)phthalate on hepatic enzyme activities and lipid peroxidation in the rat by Lake, B G, Kozlen, S L, Evans, J G, Gray, T J, Young, P J, Gangolli, S D

“…Male Sprague-Dawley rats were fed diets containing either 0.5% clofibric acid (CA) or 2% di-(2-ethylhexyl)phthalate (DEHP) for 2 years. Both compounds produced…”
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Efflux of bis-carboxyethyl-carboxyfluorescein (BCECF) by a novel ATP-dependent transport mechanism in epithelial cells by Allen, C N, Harpur, E S, Gray, T J, Simmons, N L, Hirst, B H

“…The efflux of the intracellular pH fluorochrome 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) was quantified in four cultured epithelial cell…”
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The relative hypolipidaemic activity and hepatic effects of ciprofibrate enantiomers in the rat by Graham, M J, Winham, M A, Harpur, E S, Bonner, F W, Gray, T J

“…The aim of this study was to establish whether the individual enantiomers of racemic ciprofibrate, a potent hypolipidaemic agent and peroxisome proliferator,…”
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A study of the nephrotoxicity of three cephalosporins in rabbits using 1H NMR spectroscopy by Halligan, Susan, Byard, Stephen J., Spencer, Andrew J., Gray, Tim J.B., Harpur, Ernest S., Bonner, Frank W.

“…Male New Zealand White rabbits received a single intravenous injection of 125 mg/kg cephaloridine, 500 mg/kg cefoperazone or 1000 mg/kg cephalothin…”
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