Search Results - "GRAY, L. Earl"

In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor assays by Evans, Nicola, Conley, Justin M., Cardon, Mary, Hartig, Phillip, Medlock-Kakaley, Elizabeth, Gray, L. Earl

“…Data demonstrate numerous per- and polyfluoroalkyl substances (PFAS) activate peroxisome proliferator-activated receptor alpha (PPARα), however, additional…”
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Biologically relevant reductions in fetal testosterone and Insl3 induced by in utero exposure to high levels of di-isononyl phthalate (DINP) in male rats by Earl Gray, L.

“…Some phthalate esters alter male rat reproductive development during sexual differentiation by interfering with fetal testis maturation resulting in reduced…”
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Hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) alters maternal and fetal glucose and lipid metabolism and produces neonatal mortality, low birthweight, and hepatomegaly in the Sprague-Dawley rat by Conley, Justin M., Lambright, Christy S., Evans, Nicola, McCord, James, Strynar, Mark J., Hill, Donna, Medlock-Kakaley, Elizabeth, Wilson, Vickie S., Gray, L. Earl

“…[Display omitted] •HFPO-DA (or GenX) is a developmental toxicant in the rat.•Dysregulation of carbohydrate and lipid metabolism are critical key events.•PPAR…”
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Maternal and Neonatal Effects of Maternal Oral Exposure to Perfluoro-2-methoxyacetic Acid (PFMOAA) during Pregnancy and Early Lactation in the Sprague–Dawley Rat by Conley, Justin M., Lambright, Christy S., Evans, Nicola, Bangma, Jacqueline, Ford, Jermaine, Hill, Donna, Medlock-Kakaley, Elizabeth, Gray, L. Earl

“…Perfluoro-2-methoxyacetic acid (PFMOAA) is a short-chain perfluoroalkyl ether carboxylic acid that has been detected at high concentrations (∼10 μg/L) in…”
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A mixture of 15 phthalates and pesticides below individual chemical no observed adverse effect levels (NOAELs) produces reproductive tract malformations in the male rat by Conley, Justin M., Lambright, Christy S., Evans, Nicola, Cardon, Mary, Medlock-Kakaley, Elizabeth, Wilson, Vickie S., Gray, L. Earl

“…•Multiple molecular initiating events lead to adverse male reproductive development.•Rat dams exposed to mixture of 9 phthalates, 5 pesticides, and 1 pesticide…”
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Cumulative maternal and neonatal effects of combined exposure to a mixture of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) during pregnancy in the Sprague-Dawley rat by Conley, Justin M., Lambright, Christy S., Evans, Nicola, Medlock-Kakaley, Elizabeth, Dixon, Aaron, Hill, Donna, McCord, James, Strynar, Mark J., Ford, Jermaine, Gray, L. Earl

“…Globally, biomonitoring data demonstrate virtually all humans carry residues of multiple per- and polyfluoroalkyl substances (PFAS). Despite pervasive…”
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Developmental toxicity of Nafion byproduct 2 (NBP2) in the Sprague-Dawley rat with comparisons to hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) and perfluorooctane sulfonate (PFOS) by Conley, Justin M., Lambright, Christy S., Evans, Nicola, Medlock-Kakaley, Elizabeth, Hill, Donna, McCord, James, Strynar, Mark J., Wehmas, Leah C., Hester, Susan, MacMillan, Denise K., Gray, L. Earl

“…[Display omitted] Nafion byproduct 2 (NBP2) is a polyfluoroalkyl ether sulfonic acid that was recently detected in surface water, drinking water, and human…”
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Long-chain perfluoroalkylether carboxylic acids PFO5DoA and PFO4DA alter glucose, bile acid, and thyroid hormone homeostasis in fetal rats from 5-day maternal oral exposure by Conley, Justin M., Lambright, Christy S., Evans, Nicola, Bangma, Jacqueline, Ford, Jermaine, Hill, Donna, Gray, L. Earl

“…Chemical monitoring studies in North Carolina, USA and Shandong, China have reported detections of perfluoroalkylether carboxylic acids of increasing chain…”
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Dose additive maternal and offspring effects of oral maternal exposure to a mixture of three PFAS (HFPO-DA, NBP2, PFOS) during pregnancy in the Sprague-Dawley rat by Conley, Justin M., Lambright, Christy S., Evans, Nicola, Farraj, Aimen K., Smoot, Jacob, Grindstaff, Rachel D., Hill, Donna, McCord, James, Medlock-Kakaley, Elizabeth, Dixon, Aaron, Hines, Erin, Gray, L. Earl

“…Simultaneous exposure to multiple per- and polyfluoroalkyl substances (PFAS) is common in humans across the globe. Individual PFAS are associated with adverse…”
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Exploring maternal and developmental toxicity of perfluoroalkyl ether acids PFO4DA and PFO5DoA using hepatic transcriptomics and serum metabolomics by Jackson, Thomas W., Lambright, Christy S., Evans, Nicola, Wehmas, Leah C., MacMillan, Denise K., Bangma, Jacqueline, Gray, L. Earl, Conley, Justin M.

“…Production of per- and polyfluoroalkyl substances (PFAS) has shifted from long-chain perfluoroalkyl acids to short-chain compounds and those with ether bonds…”
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Environmental Factors and Puberty Timing: Expert Panel Research Needs by Buck Louis, Germaine M, Gray, L. Earl, Jr, Marcus, Michele, Ojeda, Sergio R, Pescovitz, Ora H, Witchel, Selma Feldman, Sippell, Wolfgang, Abbott, David H, Soto, Ana, Tyl, Rochelle W, Bourguignon, Jean-Pierre, Skakkebaek, Niels E, Swan, Shanna H, Golub, Mari S, Wabitsch, Martin, Toppari, Jorma, Euling, Susan Y

“…Serono Symposia International convened an expert panel to review the impact of environmental influences on the regulation of pubertal onset and progression…”
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De Facto Water Reuse: Bioassay suite approach delivers depth and breadth in endocrine active compound detection by Medlock Kakaley, Elizabeth K., Blackwell, Brett R., Cardon, Mary C., Conley, Justin M., Evans, Nicola, Feifarek, David J., Furlong, Edward T., Glassmeyer, Susan T., Gray, L. Earl, Hartig, Phillip C., Kolpin, Dana W., Mills, Marc A., Rosenblum, Laura, Villeneuve, Daniel L., Wilson, Vickie S.

“…[Display omitted] •A suite of in vitro assays was applied to detect biological activity.•Estrogenic and glucocorticoid activity in effluent was corroborated by…”
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Cumulative effects of antiandrogenic chemical mixtures and their relevance to human health risk assessment by Howdeshell, Kembra L., Hotchkiss, Andrew K., Gray, L. Earl

“…•Many chemicals disrupt androgen-sensitive male reproductive development in the rat.•Mixtures of antiandrogenic chemicals act via dose addition, regardless of…”
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Adverse Maternal, Fetal, and Postnatal Effects of Hexafluoropropylene Oxide Dimer Acid (GenX) from Oral Gestational Exposure in Sprague-Dawley Rats by Conley, Justin M, Lambright, Christy S, Evans, Nicola, Strynar, Mark J, McCord, James, McIntyre, Barry S, Travlos, Gregory S, Cardon, Mary C, Medlock-Kakaley, Elizabeth, Hartig, Phillip C, Wilson, Vickie S, Gray, Jr, L Earl

“…Hexafluoropropylene oxide dimer acid [(HFPO-DA), GenX] is a member of the per- and polyfluoroalkyl substances (PFAS) chemical class, and elevated levels of…”
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In Utero and Lactational Exposure to Bisphenol A, In Contrast to Ethinyl Estradiol, Does Not Alter Sexually Dimorphic Behavior, Puberty, Fertility, and Anatomy of Female LE Rats by Ryan, Bryce C., Hotchkiss, Andrew K., Crofton, Kevin M., Gray, L. Earl

“…Many chemicals released into the environment display estrogenic activity including the oral contraceptive ethinyl estradiol (EE2) and the plastic monomer…”
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Mechanisms of action of phthalate esters, individually and in combination, to induce abnormal reproductive development in male laboratory rats by Howdeshell, Kembra L., Rider, Cynthia V., Wilson, Vickie S., Gray, L. Earl

“…Phthalate esters are high production volume chemicals used to impart flexibility to polyvinyl chloride products as well as other applications. In the male…”
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In utero exposure to simvastatin reduces postnatal survival and permanently alters reproductive tract development in the Crl:CD(SD) male rat by Beverly, Brandiese E.J., Furr, Johnathan R., Lambright, Christy S., Wilson, Vickie S., McIntyre, Barry S., Foster, Paul M.D., Travlos, Greg, Earl Gray, L.

“…We showed previously that in utero exposure to the cholesterol-lowering drug simvastatin (SMV) during sex differentiation lowers fetal lipids and testicular…”
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NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A by Chapin, Robert E., Adams, Jane, Boekelheide, Kim, Gray, L. Earl, Hayward, Simon W., Lees, Peter S.J., McIntyre, Barry S., Portier, Kenneth M., Schnorr, Teresa M., Selevan, Sherry G., Vandenbergh, John G., Woskie, Susan R.

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In utero phthalate effects in the female rat: A model for MRKH syndrome by Hannas, Bethany R., Howdeshell, Kembra L., Furr, Johnathan, Earl Gray, L.

“…•A chemically induced animal model of the human MRKH syndrome.•A phthalate syndrome in female rats: uterine and vaginal agenesis.•A phthalate mixture disrupts…”
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Cumulative Effects of In Utero Administration of Mixtures of “Antiandrogens” on Male Rat Reproductive Development by Rider, Cynthia V., Wilson, Vickie S., Howdeshell, Kembra L., Hotchkiss, Andrew K., Furr, Johnathan R., Lambright, Christy R., Earl Gray, L.

“…Although risk assessments are typically conducted on a chemical-by-chemical basis, the 1996 Food Quality Protection Act (FQPA) required the Environmental…”
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