Search Results - "GRAY, Daniel C"

Sexually Dimorphic Neurons in the Ventromedial Hypothalamus Govern Mating in Both Sexes and Aggression in Males by Yang, Cindy F., Chiang, Michael C., Gray, Daniel C., Prabhakaran, Mahalakshmi, Alvarado, Maricruz, Juntti, Scott A., Unger, Elizabeth K., Wells, James A., Shah, Nirao M.

“…Sexual dimorphisms in the brain underlie behavioral sex differences, but the function of individual sexually dimorphic neuronal populations is poorly…”
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Small-Molecule Activators of a Proenzyme by Wolan, Dennis W, Zorn, Julie A, Gray, Daniel C, Wells, James A

“…Virtually all of the 560 human proteases are stored as inactive proenyzmes and are strictly regulated. We report the identification and characterization of the…”
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Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents by Degtyarev, Michael, De Mazière, Ann, Orr, Christine, Lin, Jie, Lee, Brian B, Tien, Janet Y, Prior, Wei W, van Dijk, Suzanne, Wu, Hong, Gray, Daniel C, Davis, David P, Stern, Howard M, Murray, Lesley J, Hoeflich, Klaus P, Klumperman, Judith, Friedman, Lori S, Lin, Kui

“…Although Akt is known as a survival kinase, inhibitors of the phosphatidylinositol 3-kinase (PI3K)-Akt pathway do not always induce substantial apoptosis. We…”
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Oncogenic BRAF is required for tumor growth and maintenance in melanoma models by HOEFLICH, Klaus P, GRAY, Daniel C, MURRAY, Lesley J, DAVIS, David P, SESHAGIRI, Somasekar, EBY, Michael T, TIEN, Janet Y, LEO WONG, BOWER, Janeko, GOGINENI, Alvin, JIPING ZHA, COLE, Mary J, STERN, Howard M

“…The usual paradigm for developing kinase inhibitors in oncology is to use a high-affinity proof-of-concept inhibitor with acceptable metabolic properties for…”
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Engineered cellular gene-replacement platform for selective and inducible proteolytic profiling by Morgan, Charles W, Juan E. Diaz, Samantha G. Zeitlin, Daniel C. Gray, James A. Wells

“…Cellular demolition during apoptosis is completed by executioner caspases, that selectively cleave more than 1,500 proteins but whose individual roles are…”
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In-vivo imaging of retinal nerve fiber layer vasculature: imaging histology comparison by Scoles, Drew, Gray, Daniel C, Hunter, Jennifer J, Wolfe, Robert, Gee, Bernard P, Geng, Ying, Masella, Benjamin D, Libby, Richard T, Russell, Stephen, Williams, David R, Merigan, William H

“…Although it has been suggested that alterations of nerve fiber layer vasculature may be involved in the etiology of eye diseases, including glaucoma, it has…”
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Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease by Gray, Daniel C., Mahrus, Sami, Wells, James A.

“…Apoptosis is a conserved cellular pathway that results in the activation of cysteine- aspartyl proteases, or caspases. To dissect the nonredundant roles of the…”
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Inhibitor hijacking of Akt activation by Shokat, Kevan M, Okuzumi, Tatsuya, Fiedler, Dorothea, Zhang, Chao, Gray, Daniel C, Aizenstein, Brian, Hoffman, Randy

“…The kinase Akt plays a central role as a regulator of multiple growth factor input signals, thus making it an attractive anticancer drug target. A-443654 is an…”
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Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface by Shigdel, Uddhav K., Lee, Seung-Joo, Sowa, Mathew E., Bowman, Brian R., Robison, Keith, Zhou, Minyun, Pua, Khian Hong, Stiles, Dylan T., Blodgett, Joshua A. V., Udwary, Daniel W., Rajczewski, Andrew T., Mann, Alan S., Mostafavi, Siavash, Hardy, Tara, Arya, Sukrat, Weng, Zhigang, Stewart, Michelle, Kenyon, Kyle, Morgenstern, Jay P., Pan, Ende, Gray, Daniel C., Pollock, Roy M., Fry, Andrew M., Klausner, Richard D., Townson, Sharon A., Verdine, Gregory L.

“…The vast majority of intracellular protein targets are refractory toward small-molecule therapeutic engagement, and additional therapeutic modalities are…”
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pHUSH: a single vector system for conditional gene expression by Gray, Daniel C, Hoeflich, Klaus P, Peng, Li, Gu, Zhenyu, Gogineni, Alvin, Murray, Lesley J, Eby, Mike, Kljavin, Noelyn, Seshagiri, Somasekar, Cole, Mary J, Davis, David P

“…Conditional expression vectors have become a valuable research tool to avoid artefacts that may result from traditional gene expression studies. However, most…”
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Development and Validation of a Mobile Application to Detect Visual Dysfunction Following Mild Traumatic Brain Injury by Linder, Susan M, Koop, Mandy Miller, Tucker, Diane, Guzi, Karen, Gray, Daniel C, Alberts, Jay L

“…ABSTRACT Introduction Following mild traumatic brain injury, visual dysfunction is a common occurrence, yet the condition often goes undiagnosed. A mobile…”
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Light-Induced Retinal Changes Observed with High-Resolution Autofluorescence Imaging of the Retinal Pigment Epithelium by Morgan, Jessica I. W, Hunter, Jennifer J, Masella, Benjamin, Wolfe, Robert, Gray, Daniel C, Merigan, William H, Delori, Francois C, Williams, David R

“…Autofluorescence fundus imaging using an adaptive optics scanning laser ophthalmoscope (AOSLO) allows for imaging of individual retinal pigment epithelial…”
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In vivo fluorescence imaging of primate retinal ganglion cells and retinal pigment epithelial cells by Gray, Daniel C, Merigan, William, Wolfing, Jessica I, Gee, Bernard P, Porter, Jason, Dubra, Alfredo, Twietmeyer, Ted H, Ahamd, Kamran, Tumbar, Remy, Reinholz, Fred, Williams, David R

“…The ability to resolve single cells noninvasively in the living retina has important applications for the study of normal retina, diseased retina, and the…”
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In Vivo Imaging of Microscopic Structures in the Rat Retina by Geng, Ying, Greenberg, Kenneth P, Wolfe, Robert, Gray, Daniel C, Hunter, Jennifer J, Dubra, Alfredo, Flannery, John G, Williams, David R, Porter, Jason

“…The ability to resolve single retinal cells in rodents in vivo has applications in rodent models of the visual system and retinal disease. The authors have…”
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In Vivo Imaging of the Fine Structure of Rhodamine-Labeled Macaque Retinal Ganglion Cells by Gray, Daniel C, Wolfe, Robert, Gee, Bernard P, Scoles, Drew, Geng, Ying, Masella, Benjamin D, Dubra, Alfredo, Luque, Sergio, Williams, David R, Merigan, William H

“…The extent to which the fine structure of single ganglion cells, such as dendrites and axons, can be resolved in retinal images obtained from the living…”
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Dual-mode laparoscopic fluorescence image-guided surgery using a single camera by Gray, Daniel C, Kim, Evgenia M, Cotero, Victoria E, Bajaj, Anshika, Staudinger, V Paul, Hehir, Cristina A Tan, Yazdanfar, Siavash

“…Iatrogenic nerve damage is a leading cause of morbidity associated with many common surgical procedures. Complications arising from these injuries may result…”
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Regulation of ERK3/MAPK6 expression by BRAF by HOEFLICH, Klaus P, EBY, Michael T, FORREST, William F, GRAY, Daniel C, TIEN, Janet Y, STERN, Howard M, MURRAY, Lesley J, DAVIS, David P, MODRUSAN, Zora, SESHAGIRI, Somasekar

“…Several forms of cancer are characterized by frequent activating mutations in the serine/threonine kinase, BRAF. Substitution of glutamic acid for valine at…”
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Small Molecule Activation of Apoptotic Caspases by Zorn, Julie Anne, Wolan, Dennis W., Gray, Daniel C., Wells, James A.

“…Caspases comprise a family of cysteine aspartyl proteases that are expressed as inactive zymogens, or procaspases. These enzymes require proteolytic processing…”
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Using Commercial Source Measure Units for Traceable RF Power Measurements by Gray, Daniel C., Hagerstrom, Aaron M., Roberts, Zenn C., Long, Christian J.

“…As a National Metrology Institute (NMI), the National Institute of Standards and Technology (NIST) maintains traceable measurement capabilities for a variety…”
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Traceable RF Power Metering Procedures With Thermoelectric Sensors by Roberts, Zenn C., Gray, Daniel C., Neylon, Vincent, Stelson, Angela C., Hagerstrom, Aaron M., Long, Christian J.

“…The National Institute of Standards and Technology (NIST) maintains the United States' primary standards for traceable RF and mm-wave power measurements. In…”
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