Search Results - "GRAVALLESE, Ellen M"

Rheumatoid Arthritis — Common Origins, Divergent Mechanisms by Gravallese, Ellen M., Firestein, Gary S.

“…Rheumatoid arthritis is a chronic, systemic autoimmune disease manifested primarily as inflammatory arthritis, typically involving the small joints of the…”
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Effects of the IL-23–IL-17 pathway on bone in spondyloarthritis by Gravallese, Ellen M., Schett, Georg

“…Over the past several years, a pathophysiological role for the IL-23–IL-17 pathway in human disease has been defined. A subset of rheumatic diseases, including…”
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Bone Loss in Rheumatoid Arthritis: Basic Mechanisms and Clinical Implications by Shim, Jae-hyuck, Stavre, Zheni, Gravallese, Ellen M.

“…Patients with rheumatoid arthritis (RA) have historically developed progressive damage of articular bone and cartilage, which correlates with disability over…”
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American College of Rheumatology Guidance for the Management of Rheumatic Disease in Adult Patients During the COVID‐19 Pandemic: Version 3 by Mikuls, Ted R., Johnson, Sindhu R., Fraenkel, Liana, Arasaratnam, Reuben J., Baden, Lindsey R., Bermas, Bonnie L., Chatham, Winn, Cohen, Stanley, Costenbader, Karen, Gravallese, Ellen M., Kalil, Andre C., Weinblatt, Michael E., Winthrop, Kevin, Mudano, Amy S., Turner, Amy, Saag, Kenneth G.

“…Objective To provide guidance to rheumatology providers on the management of adult rheumatic disease in the context of the coronavirus disease 2019 (COVID‐19)…”
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Towards an arthritis flare-responsive drug delivery system by Joshi, Nitin, Yan, Jing, Levy, Seth, Bhagchandani, Sachin, Slaughter, Kai V., Sherman, Nicholas E., Amirault, Julian, Wang, Yufeng, Riegel, Logan, He, Xueyin, Rui, Tan Shi, Valic, Michael, Vemula, Praveen K., Miranda, Oscar R., Levy, Oren, Gravallese, Ellen M., Aliprantis, Antonios O., Ermann, Joerg, Karp, Jeffrey M.

“…Local delivery of therapeutics for the treatment of inflammatory arthritis (IA) is limited by short intra-articular half-lives. Since IA severity often…”
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Intracellular Sensing of DNA in Autoinflammation and Autoimmunity by MacLauchlan, Susan, Fitzgerald, Katherine A., Gravallese, Ellen M.

“…Evidence has shown that DNA is a pathogen‐associated molecular pattern, posing a unique challenge in the discrimination between endogenous and foreign DNA…”
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Impact of Inflammation on the Osteoblast in Rheumatic Diseases by Baum, Rebecca, Gravallese, Ellen M.

“…Normal bone remodeling depends upon a balance between the action of bone-resorbing cells, osteoclasts, and bone-forming cells, osteoblasts. When this balance…”
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RANK‐Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis by O'Brien, William, Fissel, Brian M., Maeda, Yukiko, Yan, Jing, Ge, Xianpeng, Gravallese, Ellen M., Aliprantis, Antonios O., Charles, Julia F.

“…Objective Proinflammatory molecules promote osteoclast‐mediated bone erosion by up‐regulating local RANKL production. However, recent evidence suggests that…”
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Bone remodeling in rheumatic disease: a question of balance by Walsh, Nicole C, Gravallese, Ellen M

“…The past decade has observed an explosion of new information regarding the impact of inflammation on bone. In rheumatic diseases, several factors that act as…”
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American College of Rheumatology Guidance for the Management of Rheumatic Disease in Adult Patients During the COVID‐19 Pandemic: Version 2 by Mikuls, Ted R., Johnson, Sindhu R., Fraenkel, Liana, Arasaratnam, Reuben J., Baden, Lindsey R., Bermas, Bonnie L., Chatham, Winn, Cohen, Stanley, Costenbader, Karen, Gravallese, Ellen M., Kalil, Andre C., Weinblatt, Michael E., Winthrop, Kevin, Mudano, Amy S., Turner, Amy, Saag, Kenneth G.

“…Objective To provide guidance to rheumatology providers on the management of adult rheumatic disease in the context of the coronavirus disease 2019 (COVID‐19)…”
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Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis by Stavre, Zheni, Kim, Jung-Min, Yang, Yeon-Suk, Nündel, Kerstin, Chaugule, Sachin, Sato, Tadatoshi, Park, Kwang Hwan, Gao, Guangping, Gravallese, Ellen M, Shim, Jae-Hyuck

“…Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to systemic and articular bone loss by activating bone resorption and suppressing bone…”
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A role for neutrophils in early enthesitis in spondyloarthritis by Stavre, Zheni, Bridgewood, Charles, Zhou, Qiao, Maeda, Yukiko, Huang, Ting-Ting, Karman, Jozsef, Khan, Almas, Giryes, Sami, Sharif, Kassem, McGonagle, Dennis, Gravallese, Ellen M

“…Neutrophils are present in the early phases of spondyloarthritis-related uveitis, skin and intestinal disease, but their role in enthesitis, a cardinal…”
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Bone Damage in Rheumatoid Arthritis: Mechanistic Insights and Approaches to Prevention by Karmakar, Sougata, PhD, Kay, Jonathan, MD, Gravallese, Ellen M., MD

“…In rheumatoid arthritis (RA), cells within the inflamed synovium and pannus elaborate a variety of cytokines, including tumor necrosis factor (TNF) α,…”
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Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice by Baum, Rebecca, Sharma, Shruti, Carpenter, Susan, Li, Quan-Zhen, Busto, Patricia, Fitzgerald, Katherine A, Marshak-Rothstein, Ann, Gravallese, Ellen M

“…Innate immune pattern recognition receptors sense nucleic acids from microbes and orchestrate cytokine production to resolve infection. Inappropriate…”
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Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway by Matzelle, Melissa M., Gallant, Maxime A., Condon, Keith W., Walsh, Nicole C., Manning, Catherine A., Stein, Gary S., Lian, Jane B., Burr, David B., Gravallese, Ellen M.

“…Objective Inflammation in the bone microenvironment stimulates osteoclast differentiation, resulting in uncoupling of resorption and formation. Mechanisms…”
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Osteoblast Function Is Compromised at Sites of Focal Bone Erosion in Inflammatory Arthritis by Walsh, Nicole C, Reinwald, Susan, Manning, Catherine A, Condon, Keith W, Iwata, Ken, Burr, David B, Gravallese, Ellen M

“…In rheumatoid arthritis (RA), synovial inflammation results in focal erosion of articular bone. Despite treatment attenuating inflammation, repair of erosions…”
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Rheumatic diseases: the effects of inflammation on bone by Walsh, Nicole C., Crotti, Tania N., Goldring, Steven R., Gravallese, Ellen M.

“…Rheumatoid arthritis, juvenile idiopathic arthritis, the seronegative spondyloarthropathies including psoriatic arthritis, and systemic lupus erythematosus are…”
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Immune-mediated inflammatory disease therapeutics: past, present and future by McInnes, Iain B., Gravallese, Ellen M.

“…Immune-mediated inflammatory diseases are common and clinically diverse. Although they are currently incurable, the therapeutic armamentarium for…”
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mTOR Blockade by Rapamycin in Spondyloarthritis: Impact on Inflammation and New Bone Formation in vitro and in vivo by Chen, Sijia, van Tok, Melissa N, Knaup, Véronique L, Kraal, Lianne, Pots, Désiree, Bartels, Lina, Gravallese, Ellen M, Taurog, Joel D, van de Sande, Marleen, van Duivenvoorde, Leonie M, Baeten, Dominique L

“…Spondyloarthritis (SpA) is characterized by inflammation, articular bone erosions and pathologic new bone formation. Targeting TNFα or IL-17A with current…”
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Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model by Duffau, Pierre, Menn‐Josephy, Hanni, Cuda, Carla M., Dominguez, Salina, Aprahamian, Tamar R., Watkins, Amanda A., Yasuda, Kei, Monach, Paul, Lafyatis, Robert, Rice, Lisa M., Kenneth Haines, G., Gravallese, Ellen M., Baum, Rebecca, Richez, Christophe, Perlman, Harris, Bonegio, Ramon G., Rifkin, Ian R.

“…Objective Polymorphisms in the transcription factor interferon regulatory factor 5 (IRF5) are associated with an increased risk of developing rheumatoid…”
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