Search Results - "GRASHOFF, Martina"

Astrocytes evoke a robust IRF7-independent type I interferon response upon neurotropic viral infection by Weichert, Loreen, Düsedau, Henning Peter, Fritzsch, David, Schreier, Sarah, Scharf, Annika, Grashoff, Martina, Cebulski, Kristin, Michaelsen-Preusse, Kristin, Erck, Christian, Lienenklaus, Stefan, Dunay, Ildiko Rita, Kröger, Andrea

“…Abstract Background Type I interferons (IFN-I) are fundamental in controlling viral infections but fatal interferonopathy is restricted in the…”
Get full text

ER intrabody-mediated inhibition of interferon α secretion by mouse macrophages and dendritic cells by Büssow, Konrad, Themann, Philipp, Luu, Sabine, Pentrowski, Paul, Harting, Claudia, Majewski, Mira, Vollmer, Veith, Köster, Mario, Grashoff, Martina, Zawatzky, Rainer, Van den Heuvel, Joop, Kröger, Andrea, Böldicke, Thomas

“…Interferon α (IFNα) counteracts viral infections by activating various IFNα-stimulated genes (ISGs). These genes encode proteins that block viral transport…”
Get full text

Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons by Nair, Sharmila, Michaelsen-Preusse, Kristin, Finsterbusch, Katja, Stegemann-Koniszewski, Sabine, Bruder, Dunja, Grashoff, Martina, Korte, Martin, Köster, Mario, Kalinke, Ulrich, Hauser, Hansjörg, Kröger, Andrea

“…The innate immune system protects cells against invading viral pathogens by the auto- and paracrine action of type I interferon (IFN). In addition, the…”
Get full text

IRF-1 Expression Is Essential for Natural Killer Cells to Suppress Metastasis by KSIENZYK, Antje, NEUMANN, Berit, NANDAKUMAR, Ramya, FINSTERBUSCH, Katja, GRASHOFF, Martina, ZAWATZKY, Rainer, BERNHARDT, Gunter, HAUSER, Hansjörg, KRÖGER, Andrea

“…IFN-γ promotes tumoral immune surveillance, but its involvement in controlling metastases is less clear. Using a mouse model of pulmonary metastases, we show…”
Get full text

Tumor suppression by IFN regulatory factor-1 is mediated by transcriptional down-regulation of cyclin D1 by KRÖGER, Andrea, STIRNWEISS, Anja, PULVERER, Julia Elisabeth, KLAGES, Katjana, GRASHOFF, Martina, REIMANN, Jörg, HAUSER, Hansjörg

“…IFNs have been ascribed to mediate antitumor effects. IFN regulatory factor-1 (IRF-1) is a major target gene of IFNs. It inhibits cell proliferation and…”
Get full text

Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases by Chaudhry, M Zeeshan, Eschke, Kathrin, Hoffmann, Markus, Grashoff, Martina, Abassi, Leila, Kim, Yeonsu, Brunotte, Linda, Ludwig, Stephan, Kröger, Andrea, Klawonn, Frank, Pöhlmann, Stefan H, Cicin-Sain, Luka

“…Recent emergence of SARS-CoV-1 variants demonstrates the potential of this virus for targeted evolution, despite its overall genomic stability. Here we show…”
Get full text

IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction by Stirnweiss, Anja, Ksienzyk, Antje, Klages, Katjana, Rand, Ulfert, Grashoff, Martina, Hauser, Hansjörg, Kröger, Andrea

“…Viperin is an antiviral protein whose expression is highly upregulated during viral infections via IFN-dependent and/or IFN-independent pathways. We examined…”
Get full text

ER intrabody-mediated inhibition of interferon [alpha] secretion by mouse macrophages and dendritic cells by Büssow, Konrad, Themann, Philipp, Luu, Sabine, Pentrowski, Paul, Harting, Claudia, Majewski, Mira, Vollmer, Veith, Köster, Mario, Grashoff, Martina, Zawatzky, Rainer, Van den Heuvel, Joop, Kröger, Andrea, Böldicke, Thomas

“…Interferon [alpha] (IFN[alpha]) counteracts viral infections by activating various IFN[alpha]-stimulated genes (ISGs). These genes encode proteins that block…”
Get full text

Hepatitis C Virus Replication in Mouse Cells Is Restricted by IFN-Dependent and -Independent Mechanisms by Nandakumar, Ramya, Finsterbusch, Katja, Lipps, Christoph, Neumann, Berit, Grashoff, Martina, Nair, Sharmila, Hochnadel, Inga, Lienenklaus, Stefan, Wappler, Ilka, Steinmann, Eike, Hauser, Hansjörg, Pietschmann, Thomas, Kröger, Andrea

“…Background & Aims Current treatment strategies for hepatitis C virus (HCV) infection include pegylated interferon (IFN)-alfa and ribavirin. Approximately 50%…”
Get full text

Interferon Regulatory Factor-1 Protects from Fatal Neurotropic Infection with Vesicular Stomatitis Virus by Specific Inhibition of Viral Replication in Neurons: e1003999 by Nair, Sharmila, Michaelsen-Preusse, Kristin, Finsterbusch, Katja, Stegemann-Koniszewski, Sabine, Bruder, Dunja, Grashoff, Martina, Korte, Martin, Köster, Mario, Kalinke, Ulrich, Hauser, Hansjörg, Kröger, Andrea

“…The innate immune system protects cells against invading viral pathogens by the auto- and paracrine action of type I interferon (IFN). In addition, the…”
Get full text

PS1-109 IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction by Finsterbusch, Katja, Stirnweiss, Anja, Ksienzyk, Antje, Grashoff, Martina, Hauser, Hansjörg, Kröger, Andrea

Get full text

Detection of mycoplasma contaminations by the polymerase chain reaction by WIRTH, M, BERTHOLD, E, GRASHOFF, M, PFÜTZNER, H, SCHUBERT, U, HAUSER, H

“…The polymerase chain reaction (PCR) has been used for the general detection of Mollicutes. 25 Mycoplasma and Acholeplasma species were detected including…”
Get full text

PS2-078 Interferon Regulatory Factor-1 promotes NK cell-mediated suppression of lung metastasis through DNAM1/CD155 interaction by Ksienzyk, A., Neumann, Berit, Finsterbusch, Katja, RamyaNandakumar, Grashoff, Martina, Zawatzky, Rainer, Bernhardt, Günter, Hauser, Hansjörg, Kröger, Andrea

Get full text

IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR by Kirchhoff, S, Koromilas, A E, Schaper, F, Grashoff, M, Sonenberg, N, Hauser, H

“…Expression of the tumor suppressor IRF-1 results in the inhibition of cell growth and transcriptional activation of the IFN-beta gene. IFN production is not…”
Get more information