Search Results - "GRASELA, T"

The Paradox of Scientific Excellence and the Search for Productivity in Pharmaceutical Research and Development by Grasela, T H, Slusser, R

“…Scientific advances in specialty areas are proceeding at a rapid rate, but the research and development enterprise seems unable to take full advantage…”
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Pharmacodynamics of fluoroquinolones against Streptococcus pneumoniae in patients with community-acquired respiratory tract infections by AMBROSE, Paul G, GRASELA, Dennis M, GRASELA, Thaddeus H, PASSARELL, Julie, MAYER, Howard B, PIERCE, Phillip F

“…Fluoroquinolone antibiotic agents have demonstrated efficacy in the treatment of respiratory tract infections. This analysis was designed to examine the…”
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Improving Productivity With Model-Based Drug Development: An Enterprise Perspective by Grasela, T H, Slusser, R

“…The productivity of the pharma enterprise has fallen, as evidenced by a decline in regulatory submissions and less commercial success. Two major impediments to…”
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Pharmacometrics and the Transition to Model-Based Development by Grasela, T H, Dement, C W, Kolterman, O G, Fineman, M S, Grasela, D M, Honig, P, Antal, E J, Bjornsson, T D, Loh, E

“…As the transition to model‐based drug development continues, pharmacometric analysis will have an increasingly important role across the entire life cycle of…”
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Relationship between drug exposure and the efficacy and safety of bupropion sustained release for smoking cessation by Johnston, J. Andrew, Fiedler-Kelly, Jill, Glover, Elbert D., Sachs, David P. L., Grasela, Thaddeus H., DeVeaugh-Geiss, Joseph

“…A population pharmacokinetic and pharmacodynamic analysis evaluated the relationships of dose, plasma concentrations of bupropion and metabolites, and patient…”
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Hemodynamic effects of propofol : data from over 25,000 patients by HUG, C. C, MCLESKEY, C. H, NAHRWOLD, M. L, ROIZEN, M. F, STANLEY, T. H, THISTED, R. A, WALAWANDER, C. A, WHITE, P. F, APFELBAUM, J. L, GRASELA, T. H

“…To investigate clinically important hypotension and bradycardia after induction of anesthesia with propofol, we analyzed data from a Phase IV stepwise study…”
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Symptomatic Cardiotoxicity Associated with 5-Fluorouracil by Meyer, Christine C., Calis, Karim Anton, Burke, Laurie B., Walawander, Cynthia A., Grasela, Thaddeus H.

“…A prospective cohort study was conducted in 35 hospitals with oncology units to determine the incidence of symptomatic cardiotoxicity in patients receiving…”
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The Clinical Evaluation of New Drugs for Sepsis: A Prospective Study Design Based on Survival Analysis by Knaus, William A, Harrell, Frank E, Fisher, Charles J, Wagner, Douglas P, Opal, Steven M, Sadoff, Jerald C, Draper, Elizabeth A, Walawander, Cynthia A, Conboy, Kathleen, Grasela, Thaddeus H

“…Objective.—To develop a survival model and severity assessment method to estimate the 28-day mortality risk for patients with sepsis syndrome entering phase 2…”
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Population Pharmacokinetics of Lamotrigine Adjunctive Therapy in Adults with Epilepsy by Grasela, Thaddeus H., Fiedler-Kelly, Jill, Cox, Eugène, Womble, Gilda P., Risner, Marcus E., Chen, Chao

“…Plasma concentrations of lamotrigine, an antiepileptic drug obtained in three adult controlled clinical trials conducted in the United States were pooled and…”
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Pretreatment Regimens for Adverse Events Related to Infusion of Amphotericin B by Goodwin, S. Diane, Cleary, John D., Walawander, Cynthia A., Taylor, Jerry W., Grasela, Thaddeus H.

“…Infusion-related adverse events (IRAEs) such as nausea, vomiting, fever, chills, and thrombophlebitis that are associated with amphotericin B therapy often…”
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Prospective use of population pharmacokinetics/pharmacodynamics in the development of cisatracurium by SCHMITH, V. D, FIEDLER-KELLY, J, PHILLIPS, L, GRASELA, T. H

“…The population PK/PD approach was prospectively used to determine the PK/PD of cisatracurium in various subgroups of healthy surgical patients. Plasma…”
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The initial clinical experience of 1819 physicians in maintaining anesthesia with propofol : characteristics associated with prolonged time to awakening by APFELBAUM, J. L, GRASELA, T. H, HUG, C. C, MCLESKEY, C. H, NAHRWOLD, M. L, ROIZEN, M. F, STANLEY, T. H, THISTED, R. A, WALAWANDER, C. A, WHITE, P. F

“…In October 1989, propofol underwent Phase IV Food and Drug Administration testing that involved 25,981 patients, 1722 institutions, and 1819 anesthesiologists…”
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Population pharmacokinetics of tirilazad : Effects of weight, gender, concomitant phenytoin, and subarachnoid hemorrhage by FLEISHAKER, J. C, FIEDLER-KELLY, J, GRASELA, T. H

“…Data collected during Phase I and II in the development of tirilazad were pooled and analyzed using nonlinear mixed effects models to assess covariates which…”
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Inhibition of enoxacin absorption by antacids or ranitidine by GRASELA, T. H. JR, SCHENTAG, J. J, SEDMAN, A. J, WILTON, J. H, THOMAS, D. J, SCHULTZ, R. W, LEBSACK, M. E, KINKEL, A. W

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Pharmacoepidemiology: a scientific basis for outcomes research by Grasela, T H

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Adverse events in a multicenter phase IV study of propofol : evaluation by anesthesiologists and postanesthesia care unit nurses by MCLESKEY, C. H, WALAWANDER, C. A, NAHRWOLD, M. L, ROIZEN, M. F, STANLEY, T. H, THISTED, R. A, WHITE, P. F, APFELBAUM, J. L, GRASELA, T. H, HUG, C. C

“…Phase II and III studies are tightly controlled trials investigating adverse effects before government approval of a new drug. However, because postapproval…”
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Dose Proportionality of Cisatracurium by Schmith, Virginia D., Fiedler-Kelly, Jill, Phillips, Luann, Grasela Jr, Thaddeus H.

“…The dose proportionality of cisatracurium pharmacokinetics was assessed using a population approach by incorporating the collection of sparse blood samples…”
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A population pharmacokinetic-pharmacodynamic analysis and model validation of azimilide by Phillips, L

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Analysis of Potential Risk Factors Associated with the Development of Pancreatitis in Phase I Patients with AIDS or AIDS-Related Complex Receiving Didanosine by Grasela, Thaddeus H., Walawander, Cynthia A., Beltangady, Mohan, Knupp, Catherine A., Martin, Russell R., Dunkle, Lisa M., Barbhaiya, Rashmi H., Pittman, Kenneth A., Dolin, Raphael, Valentine, Fred T., Liebman, Howard A.

“…Phase I dose-escalating trials of didanosine revealeddose-limiting toxicities, including pancreatitis, and established a total daily dose of 12.5 mg/kg/day as…”
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Inhibition of theophylline clearance by coadministered ofloxacin without alteration of theophylline effects by GREGOIRE, S. L, GRASELA, T. H. JR, FREER, J. P, TACK, K. J, SCHENTAG, J. J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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