Search Results - "GRANTHAM, JARED J"

Autosomal Dominant Polycystic Kidney Disease by Grantham, Jared J

“…Shortly after being elbowed in the flank during a basketball game, a 35-year-old healthy man has severe, colicky abdominal pain followed by gross hematuria. A…”
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The importance of total kidney volume in evaluating progression of polycystic kidney disease by Grantham, Jared J., Torres, Vicente E.

“…Key Points In autosomal dominant polycystic kidney disease (ADPKD), renal cyst formation begins in utero and continues throughout life Renal cysts originate in…”
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Rationale for early treatment of polycystic kidney disease by Grantham, Jared J.

“…In hereditary cystic disorders, renal injury begins with the formation of the first cyst. Renal injury may manifest as large kidneys, abdominal pain,…”
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Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease by Schrier, Robert W, Abebe, Kaleab Z, Perrone, Ronald D, Torres, Vicente E, Braun, William E, Steinman, Theodore I, Winklhofer, Franz T, Brosnahan, Godela, Czarnecki, Peter G, Hogan, Marie C, Miskulin, Dana C, Rahbari-Oskoui, Frederic F, Grantham, Jared J, Harris, Peter C, Flessner, Michael F, Bae, Kyongtae T, Moore, Charity G, Chapman, Arlene B

“…In patients with autosomal dominant polycystic kidney disease, the rate of increase in total kidney volume was not slowed by lisinopril and telmisartan, as…”
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Angiotensin Blockade in Late Autosomal Dominant Polycystic Kidney Disease by Torres, Vicente E, Abebe, Kaleab Z, Chapman, Arlene B, Schrier, Robert W, Braun, William E, Steinman, Theodore I, Winklhofer, Franz T, Brosnahan, Godela, Czarnecki, Peter G, Hogan, Marie C, Miskulin, Dana C, Rahbari-Oskoui, Frederic F, Grantham, Jared J, Harris, Peter C, Flessner, Michael F, Moore, Charity G, Perrone, Ronald D

“…This trial tested single versus dual inhibition of the renin–angiotensin–aldosterone system in ADPKD. ACE-inhibitor monotherapy controlled blood pressure in…”
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Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease by Chen, Li, Zhou, Xia, Fan, Lucy X, Yao, Ying, Swenson-Fields, Katherine I, Gadjeva, Mihaela, Wallace, Darren P, Peters, Dorien J M, Yu, Alan, Grantham, Jared J, Li, Xiaogang

“…Autosomal dominant polycystic kidney disease (ADPKD) is characterized by renal cyst formation, inflammation, and fibrosis. Macrophages infiltrate cystic…”
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Effect of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease by CKD Stage: Results from the TEMPO 3:4 Trial by Torres, Vicente E, Higashihara, Eiji, Devuyst, Olivier, Chapman, Arlene B, Gansevoort, Ronald T, Grantham, Jared J, Perrone, Ronald D, Ouyang, John, Blais, Jaime D, Czerwiec, Frank S

“…and objectives The Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes 3:4 study demonstrated a…”
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Kidney Volume and Functional Outcomes in Autosomal Dominant Polycystic Kidney Disease by Chapman, Arlene B, Bost, James E, Torres, Vicente E, Guay-Woodford, Lisa, Bae, Kyongtae Ty, Landsittel, Douglas, Li, Jie, King, Bernard F, Martin, Diego, Wetzel, Louis H, Lockhart, Mark E, Harris, Peter C, Moxey-Mims, Marva, Flessner, Mike, Bennett, William M, Grantham, Jared J

“…Autosomal dominant polycystic kidney disease (ADPKD) is characterized by increased total kidney volume (TKV) and renal failure. This study aimed to determine…”
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Predicted Mutation Strength of Nontruncating PKD1 Mutations Aids Genotype-Phenotype Correlations in Autosomal Dominant Polycystic Kidney Disease by Heyer, Christina M, Sundsbak, Jamie L, Abebe, Kaleab Z, Chapman, Arlene B, Torres, Vicente E, Grantham, Jared J, Bae, Kyongtae T, Schrier, Robert W, Perrone, Ronald D, Braun, William E, Steinman, Theodore I, Mrug, Michal, Yu, Alan S L, Brosnahan, Godela, Hopp, Katharina, Irazabal, Maria V, Bennett, William M, Flessner, Michael F, Moore, Charity G, Landsittel, Douglas, Harris, Peter C

“…Autosomal dominant polycystic kidney disease (ADPKD) often results in ESRD but with a highly variable course. Mutations to PKD1 or PKD2 cause ADPKD; both loci…”
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Dietary salt restriction is beneficial to the management of autosomal dominant polycystic kidney disease by Torres, Vicente E, Abebe, Kaleab Z, Schrier, Robert W, Perrone, Ronald D, Chapman, Arlene B, Yu, Alan S, Braun, William E, Steinman, Theodore I, Brosnahan, Godela, Hogan, Marie C, Rahbari, Frederic F, Grantham, Jared J, Bae, Kyongtae T, Moore, Charity G, Flessner, Michael F

“…The CRISP study of polycystic kidney disease (PKD) found that urinary sodium excretion associated with the rate of total kidney volume increase. Whether sodium…”
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A Case for Water in the Treatment of Polycystic Kidney Disease by Torres, Vicente E, Bankir, Lise, Grantham, Jared J

“…Autosomal dominant polycystic disease (ADPKD) is an inherited disorder characterized by the development within renal tubules of innumerable cysts that…”
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Rationale and Design of the TEMPO (Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes) 3-4 Study by Torres, Vicente E., MD, PhD, Meijer, Esther, MD, Bae, Kyongtae T., MD, PhD, Chapman, Arlene B., MD, Devuyst, Olivier, MD, PhD, Gansevoort, Ron T., MD, PhD, Grantham, Jared J., MD, Higashihara, Eiji, MD, Perrone, Ronald D., MD, Krasa, Holly B., MS, Ouyang, John J., PhD, Czerwiec, Frank S., MD, PhD

“…Background Current management of autosomal dominant polycystic kidney disease (ADPKD) is focused on treating disease complications, not on slowing cyst…”
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Volume Progression in Autosomal Dominant Polycystic Kidney Disease: The Major Factor Determining Clinical Outcomes by Grantham, Jared J, Chapman, Arlene B, Torres, Vicente E

“…Autosomal dominant polycystic kidney disease (PKD) is a hereditary condition characterized by the progressive enlargement of innumerable renal cysts that…”
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Tolvaptan in Autosomal Dominant Polycystic Kidney Disease: Three Years' Experience by Higashihara, Eiji, Torres, Vicente E, Chapman, Arlene B, Grantham, Jared J, Bae, Kyongtae, Watnick, Terry J, Horie, Shigeo, Nutahara, Kikuo, Ouyang, John, Krasa, Holly B, Czerwiec, Frank S

“…Autosomal dominant polycystic kidney disease (ADPKD), a frequent cause of end-stage renal disease, has no cure. V2-specific vasopressin receptor antagonists…”
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Albuminuria and tolvaptan in autosomal-dominant polycystic kidney disease: results of the TEMPO 3:4 Trial by Gansevoort, Ron T, Meijer, Esther, Chapman, Arlene B, Czerwiec, Frank S, Devuyst, Olivier, Grantham, Jared J, Higashihara, Eiji, Krasa, Holly B, Ouyang, John, Perrone, Ronald D, Torres, Vicente E

“…The TEMPO 3:4 Trial results suggested that tolvaptan had no effect compared with placebo on albuminuria in autosomal-dominant polycystic kidney disease (ADPKD)…”
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Imaging for the prognosis of autosomal dominant polycystic kidney disease by Grantham, Jared J, Bae, Kyongtae T

“…The defining characteristic of autosomal dominant polycystic kidney disease is the progressive formation and enlargement of large numbers of renal cysts, which…”
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Tolvaptan suppresses monocyte chemotactic protein-1 excretion in autosomal-dominant polycystic kidney disease by Grantham, Jared J, Chapman, Arlene B, Blais, Jaime, Czerwiec, Frank S, Devuyst, Olivier, Gansevoort, Ron T, Higashihara, Eiji, Krasa, Holly, Zhou, Wen, Ouyang, John, Perrone, Ronald D, Torres, Vicente E

“…Autosomal-dominant polycystic kidney disease (ADPKD) is characterized by multitudes of expanding renal cysts associated with mononuclear interstitial…”
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Tubular Obstruction Leads to Progressive Proximal Tubular Injury and Atubular Glomeruli in Polycystic Kidney Disease by Galarreta, Carolina I, Grantham, Jared J, Forbes, Michael S, Maser, Robin L, Wallace, Darren P, Chevalier, Robert L

“…In polycystic kidney disease (PKD), renal parenchyma is destroyed by cysts, hypothesized to obstruct nephrons. A signature of unilateral ureteral obstruction,…”
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Urinary proteomic biomarkers for diagnosis and risk stratification of autosomal dominant polycystic kidney disease: a multicentric study by Kistler, Andreas D, Serra, Andreas L, Siwy, Justyna, Poster, Diane, Krauer, Fabienne, Torres, Vicente E, Mrug, Michal, Grantham, Jared J, Bae, Kyongtae T, Bost, James E, Mullen, William, Wüthrich, Rudolf P, Mischak, Harald, Chapman, Arlene B

“…Treatment options for autosomal dominant polycystic kidney disease (ADPKD) will likely become available in the near future, hence reliable diagnostic and…”
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Potentially Modifiable Factors Affecting the Progression of Autosomal Dominant Polycystic Kidney Disease by Torres, Vicente E., Grantham, Jared J., Chapman, Arlene B., Mrug, Michal, Bae, Kyongtae T., King, Bernard F., Wetzel, Louis H., Martin, Diego, Lockhart, Mark E., Bennett, William M., Moxey-Mims, Marva, Abebe, Kaleab Z., Lin, Yan, Bost, James E.

“…The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) was created to identify markers of disease progression in patients with…”
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