Search Results - "GRANT, J L"

Structural dissimilarity from self drives neoepitope escape from immune tolerance by Devlin, Jason R., Alonso, Jesus A., Ayres, Cory M., Keller, Grant L. J., Bobisse, Sara, Vander Kooi, Craig W., Coukos, George, Gfeller, David, Harari, Alexandre, Baker, Brian M.

“…T-cell recognition of peptides incorporating nonsynonymous mutations, or neoepitopes, is a cornerstone of tumor immunity and forms the basis of new…”
Get full text

Reversion analysis reveals the in vivo immunogenicity of a poorly MHC I-binding cancer neoepitope by Ebrahimi-Nik, Hakimeh, Moussa, Marmar, Englander, Ryan P., Singhaviranon, Summit, Michaux, Justine, Pak, HuiSong, Miyadera, Hiroko, Corwin, William L., Keller, Grant L. J., Hagymasi, Adam T., Shcheglova, Tatiana V., Coukos, George, Baker, Brian M., Mandoiu, Ion I., Bassani-Sternberg, Michal, Srivastava, Pramod K.

“…High-affinity MHC I-peptide interactions are considered essential for immunogenicity. However, some neo-epitopes with low affinity for MHC I have been reported…”
Get full text

A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry by Singh, Nishant K., Alonso, Jesus A., Devlin, Jason R., Keller, Grant L. J., Gray, George I., Chiranjivi, Adarsh K., Foote, Sara G., Landau, Lauren M., Arbuiso, Alyssa G., Weiss, Laura I., Rosenberg, Aaron M., Hellman, Lance M., Nishimura, Michael I., Baker, Brian M.

“…MHC restriction, which describes the binding of TCRs from CD4 + T cells to class II MHC proteins and TCRs from CD8 + T cells to class I MHC proteins, is a…”
Get full text

Structure Based Prediction of Neoantigen Immunogenicity by Riley, Timothy P, Keller, Grant L J, Smith, Angela R, Davancaze, Lauren M, Arbuiso, Alyssa G, Devlin, Jason R, Baker, Brian M

“…The development of immunological therapies that incorporate peptide antigens presented to T cells by MHC proteins is a long sought-after goal, particularly for…”
Get full text

Physicochemical Heuristics for Identifying High Fidelity, Near-Native Structural Models of Peptide/MHC Complexes by Keller, Grant L J, Weiss, Laura I, Baker, Brian M

“…There is long-standing interest in accurately modeling the structural features of peptides bound and presented by class I MHC proteins. This interest has grown…”
Get full text

Improving T Cell Receptor On-Target Specificity via Structure-Guided Design by Hellman, Lance M., Foley, Kendra C., Singh, Nishant K., Alonso, Jesus A., Riley, Timothy P., Devlin, Jason R., Ayres, Cory M., Keller, Grant L.J., Zhang, Yuting, Vander Kooi, Craig W., Nishimura, Michael I., Baker, Brian M.

“…T cell receptors (TCRs) have emerged as a new class of immunological therapeutics. However, though antigen specificity is a hallmark of adaptive immunity, TCRs…”
Get full text

Calculating ecological footprints at the municipal level: what is a reasonable approach for Canada? by Wilson, J., Grant, J. L.

“…No clear ecological footprint calculation strategy is available for small- and mid-sized communities within Canada. By adjusting provincial or national…”
Get full text

Chromosome territories have a highly nonspherical morphology and nonrandom positioning by Khalil, A, Grant, J L, Caddle, L B, Atzema, E, Mills, K D, Arneodo, A

“…Interphase chromosomes are organized into discrete chromosome territories (CTs) that may occupy preferred sub-nuclear positions. While chromosome size and gene…”
Get full text

Structural and physical features that distinguish tumor-controlling from inactive cancer neoepitopes by Custodio, Jean M, Ayres, Cory M, Rosales, Tatiana J, Brambley, Chad A, Arbuiso, Alyssa G, Landau, Lauren M, Keller, Grant L J, Srivastava, Pramod K, Baker, Brian M

“…Neoepitopes arising from amino acid substitutions due to single nucleotide polymorphisms are targets of T cell immune responses to cancer and are of…”
Get full text

Accurate modeling of peptide-MHC structures with AlphaFold by Mikhaylov, Victor, Brambley, Chad A, Keller, Grant L J, Arbuiso, Alyssa G, Weiss, Laura I, Baker, Brian M, Levine, Arnold J

“…Major histocompatibility complex (MHC) proteins present peptides on the cell surface for T cell surveillance. Reliable in silico prediction of which peptides…”
Get more information

A previously unappreciated polymorphism in the beta chain of I-As expressed in autoimmunity-prone SJL mice: Combined impact on antibody, CD4 T cell recognition and MHC class II dimer structural stability by Richards, Katherine A., Lavery, Courtney, Keller, Grant L.J., Miller, Jim, Baker, Brian M., Sant, Andrea J.

“…•A rare and unreported mutation was discovered in I-As expressed autoimmunity prone SJL mice.•A single amino acid polymorphism alters MHC class II structural…”
Get full text

Distribution and controls on silver mineralization in the Hackett River main zone, Nunavut, Canada; an Ag- and Pb-enriched Archean volcanogenic massive sulfide deposit by Grant, Hannah L. J, Layton-Matthews, Daniel, Peter, Jan M

“…The 2.67 Ga Hackett River volcanogenic massive sulfide (VMS) deposits located in the northeastern Slave province, Nunavut, Canada, are among the largest…”
Get full text

Defibrillators can be susceptible to electromagnetic fields from adjacent portable suction units by Lee, S.M, Hyde, D, Dimunge, A, Grant, L.J

Get full text

Regulations and safety in medical equipment design by Grant, L. J.

Get full text

Kinetic analysis and substrate specificity of Escherichia coli dimethyl sulfoxide reductase by Simala-Grant, Joanne L, Weiner, Joel H

“…Medical Research Council Group in the Molecular Biology of Membranes, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7…”
Get full text

An evaluation of the characteristics and performance of neonatal phototherapy equipment by Dicken, P, Grant, L J, Jones, S

“…This paper reviews the current state of knowledge and practice in neonatal phototherapy, and assesses methods of evaluating the characteristics and performance…”
Get more information

Association of molybdopterin guanine dinucleotide with Escherichia coli dimethyl sulfoxide reductase: effect of tungstate and a mob mutation by Rothery, R A, Grant, J L, Johnson, J L, Rajagopalan, K V, Weiner, J H

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Antibiotic susceptibility of attached and free-floating Helicobacter pylori by Simala-Grant, Joanne L., Zopf, David, Taylor, Diane E.

“…Helicobacter pylori are found attached to mucous cells of the human stomach or under the mucous layer. Models mimicking the in vivo situation may be more…”
Get full text

Characterization of a cDNA Clone Encoding Human Filaggrin and Localization of the Gene to Chromosome Region 1q21 by McKinley-Grant, Lynn J., Idler, William W., Bernstein, Isadore A., David A. D. Parry, Cannizzaro, Linda, Croce, Carlo M., Huebner, Kay, Lessin, Stuart R., Steinert, Peter M.

“…Filaggrins are an important class of intermediate filament-associated proteins that interact with keratin intermediate filaments of terminally differentiating…”
Get full text

Methods of measuring skin blood flow by Swain, I D, Grant, L J

Get more information