Search Results - "GRANOWITZ, E. V"

Hyperbaric oxygen inhibits stimulus‐induced proinflammatory cytokine synthesis by human blood‐derived monocyte‐macrophages by Benson, R. M., Minter, L. M., Osborne, B. A., Granowitz, E. V.

“…SUMMARY Hyperbaric oxygen (HBO) is 100% oxygen administered at elevated atmospheric pressure to patients with inflammatory diseases. We developed an in vitro…”
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A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses by Chernoff, AE, Granowitz, EV, Shapiro, L, Vannier, E, Lonnemann, G, Angel, JB, Kennedy, JS, Rabson, AR, Wolff, SM, Dinarello, CA

“…In vitro, IL-10 inhibits T cell proliferation and LPS-induced monocyte production of IL-1, TNF-alpha, IL-6, and IL-8. We studied the safety and…”
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Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor by GRANOWITZ, E. V, CLARK, B. D, MANCILLA, J, DINARELLO, C. A

“…The interleukin-1 receptor antagonist (IL-1ra) inhibits the binding of interleukin-1 (IL-1) to T-cell lines possessing the type I IL-1 receptor; evidence has…”
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Production of interleukin-1-receptor antagonist during experimental endotoxaemia by Granowitz, E V, Santos, A A, Poutsiaka, D D, Cannon, J G, Wilmore, D W, Wolff, S M, Dinarello, C A

“…Interleukin-1 (IL-1) has been implicated in the pathogenesis of sepsis. IL-1-receptor antagonist (IL-1ra) is a naturally occurring inhibitor of IL-1 activity…”
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Exposure to increased pressure or hyperbaric oxygen suppresses interferon-gamma secretion in whole blood cultures of healthy humans by Granowitz, E V, Skulsky, E J, Benson, R M, Wright, J, Garb, J L, Cohen, E R, Smithline, E C, Brown, R B

“…This study examines the effects of hyperoxia, increased atmospheric pressure, and hyperbaric oxygen on cytokine synthesis. Five healthy volunteers were exposed…”
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Intravenous endotoxin suppresses the cytokine response of peripheral blood mononuclear cells of healthy humans by Granowitz, EV, Porat, R, Mier, JW, Orencole, SF, Kaplanski, G, Lynch, EA, Ye, K, Vannier, E, Wolff, SM, Dinarello, CA

“…When administered parenterally, endotoxin stimulates the synthesis of IL-1, TNF-alpha, and IL-6. However, this initial injection induces tolerance; a second…”
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Detection of Tumor Necrosis Factor Soluble Receptor p55 in Blood Samples from Healthy and Endotoxemic Humans by Shapiro, Leland, Clark, Burton D., Orencole, Scott F., Poutsiaka, Debra D., Granowitz, Eric V., Dinarello, Charles A.

“…The tumor necrosis factor (TNF) soluble receptor derived from the cell surface p55 TNF receptor (TNFsRp55) is a naturally occurring substance generated during…”
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A pseudoepidemic of Alcaligenes xylosoxidans attributable to contaminated saline by Granowitz, Eric V., Keenholtz, Steven L.

“…Alcaligenes xylosoxidans is an uncommon but serious cause of nosocomial epidemics. This report describes a cluster of two patients who underwent revision of…”
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Extraintestinal Clostridium difficile: 10 years' experience at a tertiary-care hospital by Wolf, L E, Gorbach, S L, Granowitz, E V

“…To determine the clinical characteristics of patients with extraintestinal Clostridium difficile (ECD). All cultures obtained during a 10.5-year period (from…”
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Clinical, hematologic, and immunologic effects of interleukin-10 in humans by FUCHS, A. C, GRANOWITZ, E. V, CUTLER, D. L, GRINT, P. C, DINARELLO, C. A, SHAPIRO, L, VANNIER, E, LONNEMANN, G, ANGEL, J. B, KENNEDY, J. S, RABSON, A. R, RADWANSKI, E, AFFRIME, M. B

“…We conducted a double-blind, placebo-controlled study to investigate the safety, pharmacokinetics, and immunological properties of interleukin-10 (IL-10)…”
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Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells by Porat, R, Poutsiaka, D D, Miller, L C, Granowitz, E V, Dinarello, C A

“…Interleukin-1 (IL-1) is a potent stimulator of IL-8 production by fibroblasts and monocytes. In the present study, we asked how much of endotoxin (LPS)-induced…”
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Circulating Leptin during Experimental Endotoxemia in Humans by Granowitz, Eric V., Porat, Reuven, Dinarello, Charles A.

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Hematologic and immunomodulatory effects of an interleukin-1 receptor antagonist coinfusion during low-dose endotoxemia in healthy humans by GRANOWITZ, E. V, PORAT, R, SHAPIRO, L, PRIBBLE, J. P, STILES, D. M, CATALANO, M. A, WOLFF, S. M, DINARELLO, C. A, MIER, J. W, ORENCOLE, S. F, CALLAHAN, M. V, CANNON, J. G, LYNCH, E. A, KE YE, POUTSIAKA, D. D, VANNIER, E

“…Endotoxin is a component of gram-negative bacteria that causes hematologic and immunologic changes through its induction of cytokines. Interleukin-1 receptor…”
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Interleukin 1 induces HIV-1 expression in chronically infected U1 cells: blockade by interleukin 1 receptor antagonist and tumor necrosis factor binding protein type 1 by Granowitz, E V, Saget, B M, Wang, M Z, Dinarello, C A, Skolnik, P R

“…Cytokines and cytokine antagonists modulate human immunodeficiency virus (HIV) replication in vitro and may be involved in HIV disease pathogenesis. An…”
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Photosensitivity Rash in a Patient Being Treated with Ciprofloxacin by Granowitz, Eric V.

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Transforming Growth Factor-β Enhances and Pro-inflammatory Cytokines Inhibit OB Gene Expression in 3T3-L1 Adipocytes by Granowitz, Eric V.

“…Leptin is a protein which is encoded by the obese (ob) gene. It is synthesized by adipocytes and binds to receptors in the hypothalamus, thereby suppressing…”
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Hyperbaric oxygen enhances apoptosis in hematopoietic cells by Ganguly, B J, Tonomura, N, Benson, R M, Osborne, B A, Granowitz, E V

“…Hyperbaric oxygen (HBO) is 100% oxygen administered at elevated atmospheric pressure. In this study, we examined the effect of HBO on hematopoietic cell…”
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Administration of Low-Dose Endotoxin to Healthy Humans Increases C5a Binding to Circulating Neutrophils by Granowitz, Eric V., Porat, Reuven, Gelfand, Jeffrey A., Wolff, Sheldon M., Dinarello, Charles A.

“…We examined the binding of C5a to neutrophils of healthy human volunteers given endotoxin. Male volunteers aged 18-30 years were enrolled. After they fasted…”
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Gas-forming soft tissue abscess caused by Streptococcus pneumoniae by Granowitz, E V, Donaldson, W R, Skolnik, P R

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Hyperbaric oxygen enhances apoptosis in hematopoietic cells by Ganguly, B J, Tonomura, N, Benson, R M, Osborne, B A, Granowitz, E V

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