Search Results - "GRANOFF, DAN M"

Review of Meningococcal Group B Vaccines by Granoff, Dan M.

“…No broadly effective vaccines are available for prevention of group B meningococcal disease, which accounts for>50% of all cases. The group B capsule is an…”
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Binding of Complement Factor H (fH) to Neisseria meningitidis Is Specific for Human fH and Inhibits Complement Activation by Rat and Rabbit Sera by Granoff, Dan M, Welsch, Jo Anne, Ram, Sanjay

“…Complement factor H (fH), a molecule that downregulates complement activation, binds to Neisseria meningitidis and increases resistance to serum bactericidal…”
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Human factor H (FH) impairs protective meningococcal anti-FHbp antibody responses and the antibodies enhance FH binding by Costa, Isabella, Pajon, Rolando, Granoff, Dan M

“…The meningococcal 4CMenB vaccine (Bexsero; Novartis) contains four antigens that can elicit serum bactericidal activity, one of which is factor H (FH)-binding…”
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Fatal Nongroupable Neisseria meningitidis Disease in Vaccinated Patient Receiving Eculizumab by Nolfi-Donegan, Deirdre, Konar, Monica, Vianzon, Vianca, MacNeil, Jessica, Cooper, James, Lurie, Perrianne, Sedivy, Judi, Wang, Xin, Granoff, Dan M, McNamara, Lucy

“…Patients receiving eculizumab have an increased risk for meningococcal disease, but most reported cases are attributable to encapsulated meningococcal strains…”
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Differential effects of therapeutic complement inhibitors on serum bactericidal activity against non-groupable meningococcal isolates recovered from patients treated with eculizumab by Granoff, Dan M, Kim, Howard, Topaz, Nadav, MacNeil, Jessica, Wang, Xin, McNamara, Lucy A

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A Meningococcal Outer Membrane Vesicle Vaccine with Overexpressed Mutant FHbp Elicits Higher Protective Antibody Responses in Infant Rhesus Macaques than a Licensed Serogroup B Vaccine by Beernink, Peter T, Vianzon, Vianca, Lewis, Lisa A, Moe, Gregory R, Granoff, Dan M

“…MenB-4C (Bexsero; GlaxoSmithKline Biologicals) is a licensed meningococcal vaccine for capsular B strains. The vaccine contains detergent-extracted outer…”
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Complement-Mediated Bactericidal Activity of Anti-Factor H Binding Protein Monoclonal Antibodies against the Meningococcus Relies upon Blocking Factor H Binding by GIUNTINI, Serena, REASON, Donald C, GRANOFF, Dan M

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Combined Roles of Human IgG Subclass, Alternative Complement Pathway Activation, and Epitope Density in the Bactericidal Activity of Antibodies to Meningococcal Factor H Binding Protein by Giuntini, Serena, Reason, Donald C, Granoff, Dan M

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Bactericidal Antibody Responses Elicited by a Meningococcal Outer Membrane Vesicle Vaccine with Overexpressed Factor H–Binding Protein and Genetically Attenuated Endotoxin by Koeberling, Oliver, Seubert, Anja, Granoff, Dan M.

“…Background. Outer membrane vesicle (OMV) vaccines from mutant Neisseria meningitidis strains engineered to overexpress factor H-binding protein (fHbp) have…”
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Factor H-dependent alternative pathway inhibition mediated by porin B contributes to virulence of Neisseria meningitidis by Lewis, Lisa A, Vu, David M, Vasudhev, Shreekant, Shaughnessy, Jutamas, Granoff, Dan M, Ram, Sanjay

“…The identification of "factor H binding protein (fHbp)-null" invasive meningococcal isolates and the realization that widespread use of fHbp-based vaccines…”
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Bactericidal Antibody Responses Induced by Meningococcal Recombinant Chimeric Factor H-Binding Protein Vaccines by Beernink, Peter T, Granoff, Dan M

“…Factor H-binding protein (fHbp) is a novel meningococcal vaccine candidate that elicits serum antibodies that activate classical complement pathway…”
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A Newly-Identified Polymorphism in Rhesus Macaque Complement Factor H Modulates Binding Affinity for Meningococcal FHbp by Konar, Monica, Beernink, Peter T, Granoff, Dan M

“…Two meningococcal serogroup B vaccines contain Factor H binding protein (FHbp). Binding of Factor H (FH) to FHbp was thought to be specific for human or…”
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Complement-Dependent Synergistic Bactericidal Activity of Antibodies against Factor H–Binding Protein, a Sparsely Distributed Meningococcal Vaccine Antigen by Welsch, Jo Anne, Ram, Sanjay, Koeberling, Oliver, Granoff, Dan M.

“…BackgroundAntibodies to factor H (fH)–binding protein (fHBP), a meningococcal vaccine antigen, activate classical complement pathway serum bactericidal…”
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Eculizumab treatment and impaired opsonophagocytic killing of meningococci by whole blood from immunized adults by Konar, Monica, Granoff, Dan M.

“…Eculizumab, a humanized anti–complement C5 monoclonal antibody (mAb) for treatment of paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic…”
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A Critical Threshold of Meningococcal Factor H Binding Protein Expression Is Required for Increased Breadth of Protective Antibodies Elicited by Native Outer Membrane Vesicle Vaccines by Koeberling, Oliver, Delany, Isabel, Granoff, Dan M

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Design of Meningococcal Factor H Binding Protein Mutant Vaccines That Do Not Bind Human Complement Factor H by PAJON, Rolando, BEERNINK, Peter T, GRANOFF, Dan M

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Mutant Native Outer Membrane Vesicles Combined with a Serogroup A Polysaccharide Conjugate Vaccine for Prevention of Meningococcal Epidemics in Africa by Pajon, Rolando, Fergus, Andrew M, Granoff, Dan M

“…The meningococcal serogroup A (MenA) polysaccharide conjugate vaccine used in Sub-Saharan Africa does not prevent disease caused by MenW or MenX strains, which…”
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Fine Antigenic Specificity and Cooperative Bactericidal Activity of Monoclonal Antibodies Directed at the Meningococcal Vaccine Candidate Factor H-Binding Protein by Beernink, Peter T, Welsch, Jo Anne, Bar-Lev, Michal, Koeberling, Oliver, Comanducci, Maurizio, Granoff, Dan M

“…No broadly protective vaccine is available for the prevention of group B meningococcal disease. One promising candidate is factor H-binding protein (fHbp),…”
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Reconsideration of the Use of Meningococcal Polysaccharide Vaccine by Granoff, Dan M, Pollard, Andrew J

“…In 2005, a quadrivalent meningococcal conjugate vaccine was licensed in the United States for persons aged 11–55 years of age. For children aged 2–10 years…”
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Does Binding of Complement Factor H to the Meningococcal Vaccine Antigen, Factor H Binding Protein, Decrease Protective Serum Antibody Responses? by Granoff, Dan M, Ram, Sanjay, Beernink, Peter T

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