Search Results - "GRANGER, Joey P"

Animal models of preeclampsia: investigating pathophysiology and therapeutic targets by Bakrania, Bhavisha A., George, Eric M., Granger, Joey P.

“…Animal models have been critical in investigating the pathogenesis, mediators, and even therapeutic options for a number of diseases, including preeclampsia…”
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Increased risk for the development of preeclampsia in obese pregnancies: weighing in on the mechanisms by Spradley, Frank T, Palei, Ana C, Granger, Joey P

“…Preeclampsia (PE) is a pregnancy-specific disorder typically presenting as new-onset hypertension and proteinuria. While numerous epidemiological studies have…”
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Placental Growth Factor Administration Abolishes Placental Ischemia-Induced Hypertension by Spradley, Frank T, Tan, Adelene Y, Joo, Woo S, Daniels, Garrett, Kussie, Paul, Karumanchi, S Ananth, Granger, Joey P

“…Preeclampsia is a pregnancy-specific disorder of new-onset hypertension. Unfortunately, the most effective treatment is early delivery of the fetus and…”
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The Endothelin System: A Critical Player in the Pathophysiology of Preeclampsia by Granger, Joey P., Spradley, Frank T., Bakrania, Bhavisha A.

“…Purpose of Review Preeclampsia (PE) is a disorder of pregnancy typically characterized by new-onset hypertension and proteinuria after gestational week 20…”
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Bioflavonoid luteolin prevents sFlt‐1 release via HIF‐1α inhibition in cultured human placenta by Eddy, Adrian C., Chiang, Chun Yi, Rajakumar, Augustine, Spradley, Frank T., Dauer, Patricia, Granger, Joey P., Rana, Sarosh

“…Preeclampsia (PE) is a serious hypertensive complication of pregnancy and is a leading cause of maternal death and major contributor to maternal and perinatal…”
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Placental Ischemia Says "NO" to Proper NOS-Mediated Control of Vascular Tone and Blood Pressure in Preeclampsia by Palei, Ana C, Granger, Joey P, Spradley, Frank T

“…In this review, we first provide a brief overview of the nitric oxide synthase (NOS) isoforms and biochemistry. This is followed by describing what is known…”
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Recent Advances in the Understanding of the Pathophysiology of Preeclampsia by WARRINGTON, Junie P, GEORGE, Eric M, PALEI, Ana C, SPRADLEY, Frank T, GRANGER, Joey P

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Role of Endothelin in Mediating Soluble fms-Like Tyrosine Kinase 1–Induced Hypertension in Pregnant Rats by Murphy, Sydney R, LaMarca, B Babbette D, Cockrell, Kathy, Granger, Joey P

“…Although soluble fms-like tyrosine kinase 1 (sFlt-1), an antagonist of vascular endothelial growth factor and placental growth factor, has been implicated in…”
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The Endothelin Type A Receptor as a Potential Therapeutic Target in Preeclampsia by Bakrania, Bhavisha, Duncan, Jeremy, Warrington, Junie P, Granger, Joey P

“…Preeclampsia (PE) is a disorder of pregnancy typically characterized by new onset hypertension after gestational week 20 and proteinuria. Although PE is one of…”
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Induction of heme oxygenase 1 attenuates placental ischemia-induced hypertension by George, Eric M, Cockrell, Kathy, Aranay, Marietta, Csongradi, Eva, Stec, David E, Granger, Joey P

“…Recent in vitro studies have reported that heme oxygenase 1 (HO-1) downregulates the angiostatic protein soluble fms-like tyrosine kinase 1 from placental…”
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Sildenafil attenuates placental ischemia-induced hypertension by George, Eric M, Palei, Ana C, Dent, Edward A, Granger, Joey P

“…Preeclampsia is a complication of pregnancy that is marked by hypertension, proteinuria, and maternal endothelial dysfunction. A central factor in the etiology…”
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Recent Progress Toward the Understanding of the Pathophysiology of Hypertension During Preeclampsia by LaMarca, Babbette D, Gilbert, Jeffery, Granger, Joey P

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Reduced uterine perfusion pressure induces hypertension in the pregnant mouse by Intapad, Suttira, Warrington, Junie P, Spradley, Frank T, Palei, Ana C, Drummond, Heather A, Ryan, Michael J, Granger, Joey P, Alexander, Barbara T

“…Despite preeclampsia being one of the leading causes of maternal death and a major contributor of maternal and perinatal morbidity, the mechanisms responsible…”
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Matrix metalloproteinases as drug targets in preeclampsia by Palei, Ana C T, Granger, Joey P, Tanus-Santos, Jose E

“…Preeclampsia is an important syndrome complicating pregnancy. While the pathogenesis of preeclampsia is not entirely known, poor placental perfusion leading to…”
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Interleukin-17 Reduces βENaC via MAPK Signaling in Vascular Smooth Muscle Cells by Duncan, Jeremy W, Granger, Joey P, Ryan, Michael J, Drummond, Heather A

“…Degenerin proteins, such as the beta epithelial Na channel (βENaC), are essential in the intracellular signaling of pressure-induced constriction, an important…”
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Exposure to placental ischemia impairs postpartum maternal renal and cardiac function in rats by Paauw, Nina D, Joles, Jaap A, Spradley, Frank T, Bakrania, Bhavisha, Zsengeller, Zsuzsanna K, Franx, Arie, Verhaar, Marianne C, Granger, Joey P, Lely, A Titia

“…Women with a history of preeclampsia (PE) have an increased risk to develop cardiovascular and renal diseases later in life, but the mechanisms underlying this…”
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Long-Term Postpartum Cardiac Function and Its Association With Preeclampsia by deMartelly, Victoria A, Dreixler, John, Tung, Avery, Mueller, Ariel, Heimberger, Sarah, Fazal, Abid A, Naseem, Heba, Lang, Roberto, Kruse, Eric, Yamat, Megan, Granger, Joey P, Bakrania, Bhavisha A, Rodriguez-Kovacs, Javier, Rana, Sarosh, Shahul, Sajid

“…Background Preeclampsia is a prominent risk factor for long-term development of cardiovascular disease. Although existing studies report a strong correlation…”
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Preeclampsia: Pathophysiology, Challenges, and Perspectives by Rana, Sarosh, Lemoine, Elizabeth, Granger, Joey, Karumanchi, S Ananth

“…Hypertensive disorders of pregnancy—chronic hypertension, gestational hypertension, and preeclampsia—are uniquely challenging as the pathology and its…”
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Immune Mechanisms Linking Obesity and Preeclampsia by Spradley, Frank T, Palei, Ana C, Granger, Joey P

“…Preeclampsia (PE) is characterized by hypertension occurring after the twentieth week of pregnancy. It is a significant contributor to maternal and perinatal…”
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Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences by Chatre, Laurent, Ducat, Aurélien, Spradley, Frank T., Palei, Ana C., Chéreau, Christiane, Couderc, Betty, Thomas, Kamryn C., Wilson, Anna R., Amaral, Lorena M., Gaillard, Irène, Méhats, Céline, Lagoutte, Isabelle, Jacques, Sébastien, Miralles, Francisco, Batteux, Frédéric, Granger, Joey P., Ricchetti, Miria, Vaiman, Daniel

“…Preeclampsia (PE) is a high-prevalence pregnancy disease characterized by placental insufficiency, gestational hypertension, and proteinuria. Overexpression of…”
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