Search Results - "GRAGNOLI, C"

Melatonin receptor 1A (MTNR1A) gene linkage and association to type 2 diabetes in Italian families by Amin, M, Gragnoli, C

“…Melatonin regulates the mammalian circadian rhythm and plays metabolic functions such as glucose homeostasis. Both melatonin receptors (MTNR1A and MTNR1B,…”
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Genome-wide linkage and association study identifies novel genes and pathways implicated in polycystic ovarian syndrome by Amin, M, Gragnoli, C

“…Polycystic ovarian syndrome (PCOS) is a complex heterogeneous condition that affects women of reproductive age, conferring increased cardiovascular morbidity…”
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Proteasome modulator 9 and depression in type 2 diabetes by Gragnoli, C

“…The chromosome 12q24 locus is linked to bipolar disorder, depression, and type 2 diabetes (T2D). PSMD9 lies in the 12q24 locus and is linked to MODY3, T2D,…”
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Oxytocin receptor (OXTR) is a risk gene for polycystic ovarian syndrome by Amin, M, Horst, N, Wu, R, Gragnoli, C

“…Oxytocin (OXT) controls appetite, promotes diet-induced energy expenditure, and may protect against obesity. Furthermore, the oxytocin system controls ovarian…”
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Comorbidity of CRHR2 gene variants in type 2 diabetes and depression by Amin, M., Ott, J., Wu, R., Postolache, T., Vergare, M., Gragnoli, C.

“…IntroductionThe corticotropin-releasing hormone receptor 2 (CRHR2) gene encodes CRHR2, which is an important element in the hypothalamic-pituitary-adrenal…”
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The mineralocorticoid receptor gene (NR3C2) is linked to and associated with polycystic ovarian syndrome in Italian families by Amin, M, Perrelli, M, Wu, R, Gragnoli, C

“…Polycystic ovarian syndrome (PCOS) is a complex heterogeneous disorder characterized by hyperandrogenism, irregular menses, and subfertility and often…”
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Linkage and association of novel DRD2 variants to the comorbidity of type 2 diabetes and depression by Amin, M, Wu, R, Postolache, T T, Gragnoli, C

“…The dopamine receptor 2 (DRD2) binds dopamine in both central tissues (e.g., basal ganglia, pituitary gland) and peripheral tissues (e.g., adrenal gland,…”
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Novel implication of the prolactin (PRL) gene in the comorbidity of type 2 diabetes and depression by Amin, M, Wu, R, Postolache, T T, Gragnoli, C

“…The prolactin (PRL) system plays important behavioral, social, and metabolic roles, such as mediating social bonding and insulin secretion. Inherited…”
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Novel TCF7L2 familial linkage and association with Type 2 diabetes, depression, and their comorbidity by Del Bosque-Plata, L, Amin, M, Wu, R, Postolache, T T, Gragnoli, C

“…Alterations in the activity of the transcription factor 7-like 2 (TCF7L2) generate defects previously associated with neuropsychiatric disorders. We…”
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PSMD9 is linked to T2D age of onset, years of isolated and combined insulin therapy, irregular menses, and hot flashes by Del Bosque-Plata, L, Amin, M, Gragnoli, C

“…PSMD9 is a ubiquitous protein present at high concentrations in eukaryotic cells. It contributes to the degradation of intracellular proteins in the immune…”
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Dopamine–prolactin pathway potentially contributes to the schizophrenia and type 2 diabetes comorbidity by Gragnoli, C, Reeves, G M, Reazer, J, Postolache, T T

“…Schizophrenia (SCZ) and type 2 diabetes (T2D) are clinically associated, and common knowledge attributes this association to side effects of antipsychotic…”
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Heavy metals as risk factors for human diseases - a Bayesian network approach by Perrelli, M, Wu, R, Liu, D J, Lucchini, R G, Del Bosque-Plata, L, Vergare, M J, Akhter, M P, Ott, J, Gragnoli, C

“…Modern industrial agricultural processes expose human beings to multifactorial environmental pollution including heightened levels of heavy metals. The effects…”
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PSMD9 gene variants within NIDDM2 may rarely contribute to type 2 diabetes by Gragnoli, C., Cronsell, J.

“…Multiple genome‐wide scans in different populations have linked the chromosome 12q24 region, known as NIDDM2 (non‐insulin‐dependent‐diabetes, locus 2), to type…”
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Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4 alpha binding site in the promoter of the hepatocyte nuclear factor-1 alpha gene by GRAGNOLI, C, LINDNER, T, COCKBURN, B. N, KAISAKI, P. J, GRAGNOLI, F, MAROZZI, G, BELL, G. I

“…Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4 alpha binding site in the promoter of the hepatocyte nuclear factor-1…”
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Meta-analysis of the IPF1 D76N polymorphism in a worldwide type 2 diabetes population by Gragnoli, C, Cronsell, J

“…Mutations in the IPF1 gene cause MODY4; IPF1 D76N is a polymorphism, which inhibits the insulin promoter and decreases insulin-secretion. We planned to…”
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Hypothesis of the neuroendocrine cortisol pathway gene role in the comorbidity of depression, type 2 diabetes, and metabolic syndrome by Gragnoli, Claudia

“…Depression, type 2 diabetes (T2D), and metabolic syndrome (MetS) are often comorbid. Depression per se increases the risk for T2D by 60%. This risk is not…”
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NEUROG3 variants and type 2 diabetes in Italians by Milord, E, Gragnoli, C

“…Type 2 diabetes (T2D) is a complex polygenic disorder. Genetic predisposition may vary in different ethnic groups. A potential candidate gene for T2D is…”
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Early-onset Type II diabetes mellitus in Italian families due to mutations in the genes encoding hepatic nuclear factor 1α and glucokinase by GRAGNOLI, C, COCKBURN, B. N, CHIARAMONTE, F, GORINI, A, MARIETTI, G, MAROZZI, G, SIGNORINI, A. M

“…Maturity-onset-diabetes of the young (MODY) is caused by mutations in at least five different genes. Our aim was to determine the prevalence of the most common…”
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Proteasome modulator 9 gene is linked to diabetic and non-diabetic retinopathy in T2D by Gragnoli, Claudia

“…Background: Diabetic retinopathy is a long-term complication of type 2 diabetes (T2D). Non-diabetic retinopathy may be present in T2D patients as well and…”
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Double blind trial of nicotinamide in recent-onset IDDM (the IMDIAB III study) by POZZILLI, P, VISALLI, N, LUCENTINI, L, MATTEOLI, M. C, CRINO, A, CICCONETTI, C. A, TEODONIO, C, PACI, F, AMORETTI, R, PISANO, L, PENNAFINA, M. G, SANTOPADRE, G, SIGNORE, A, MAROZZI, G, MULTARI, G, SUPPA, M. A, CAMPEA, L, DE MATTIA, G. C, CASSONE FALDETTA, M, MARIETTI, G, PERRONE, F, GRECO, A. V, GHIRLANDA, G, BARONI, M. G, BUZZETTI, R, CAVALLO, M. G, BOCCUNI, M. L, FAVA, D, GRAGNOLI, C, ANDREANI, D

“…Nicotinamide has been recently introduced, in addition to intensive insulin therapy for patients with recent-onset insulin-dependent diabetes mellitus (IDDM)…”
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