Search Results - "GRAFF, Aaron H"

Flagellin-F1-V Fusion Protein Is an Effective Plague Vaccine in Mice and Two Species of Nonhuman Primates by Mizel, Steven B, Graff, Aaron H, Sriranganathan, Nammalwar, Ervin, Sean, Lees, Cynthia J, Lively, Mark O, Hantgan, Roy R, Thomas, Michael J, Wood, James, Bell, Brian

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Engineered Expression of the TLR5 Ligand Flagellin Enhances Paramyxovirus Activation of Human Dendritic Cell Function by ARIMILLI, Subhashini, JOHNSON, John B, CLARK, Kimberly M, GRAFF, Aaron H, ALEXANDER-MILLER, Martha A, MIZEL, Steven B, PARKS, Griffith D

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Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins by Bolduc, Jesalyn A., Nelson, Kimberly J., Haynes, Alexina C., Lee, Jingyun, Reisz, Julie A., Graff, Aaron H., Clodfelter, Jill E., Parsonage, Derek, Poole, Leslie B., Furdui, Cristina M., Lowther, W. Todd

“…2-Cys peroxiredoxins (Prxs) modulate hydrogen peroxide (H2O2)-mediated cell signaling. At high H2O2 levels, eukaryotic Prxs can be inactivated by…”
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Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria by Ding, Jinyue, Gumpena, Rajesh, Boily, Marc-Olivier, Caron, Alexandre, Chong, Oliver, Cox, Jennifer H, Dumais, Valerie, Gaudreault, Samuel, Graff, Aaron H, King, Andrew, Knight, John, Oballa, Renata, Surendradoss, Jayakumar, Tang, Tim, Wu, Joyce, Lowther, W. Todd, Powell, David A

“…Both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA) influence the endogenous synthesis of oxalate and are clinically validated targets for treatment…”
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Aromatic Residues at the Dimer−Dimer Interface in the Peroxiredoxin Tsa1 Facilitate Decamer Formation and Biological Function by Loberg, Matthew A, Hurtig, Jennifer E, Graff, Aaron H, Allan, Kristin M, Buchan, John A, Spencer, Matthew K, Kelly, Joseph E, Clodfelter, Jill E, Morano, Kevin A, Lowther, W. Todd, West, James D

“…To prevent the accumulation of reactive oxygen species and limit associated damage to biological macromolecules, cells express a variety of oxidant-detoxifying…”
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Enhanced antigen processing of flagellin fusion proteins promotes the antigen-specific CD8+ T cell response independently of TLR5 and MyD88 by Bates, John T, Graff, Aaron H, Phipps, James P, Grayson, Jason M, Mizel, Steven B

“…Flagellin is a highly effective adjuvant for CD4(+) T cell and humoral immune responses. However, there is conflicting data in the literature regarding the…”
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Mucosal adjuvant activity of flagellin in aged mice by Bates, John T., Honko, Anna N., Graff, Aaron H., Kock, Nancy D., Mizel, Steven B.

“…We evaluated the ability of flagellin, a highly effective mucosal adjuvant in mice and non-human primates, to promote mucosal innate and adaptive immunity in…”
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A Phase I Safety and Immunogenicity Dose Escalation Trial of Plague Vaccine, Flagellin/F1/V, in Healthy Adult Volunteers (DMID 08-0066) by Frey, Sharon E, Lottenbach, Kathleen, Graham, Irene, Anderson, Edwin, Bajwa, Kanwaldeep, May, Ryan, Mizel, Steven B., Graff, Aaron H., Belshe, Robert B.

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899A Phase I Safety and Immunogenicity Dose Escalation Trial of Plague Vaccine, Flagellin/F1/V, in Healthy Adult Volunteers (DMID 08-0066) by Frey, Sharon E, Lottenbach, Kathleen, Graham, Irene, Anderson, Edwin, Bajwa, Kanwaldeep, May, Ryan, Mizel, Steven B., Graff, Aaron H., Belshe, Robert B.

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