Search Results - "GRAEFF, R. M"

Enzymatic synthesis and characterizations of cyclic GDP-ribose. A procedure for distinguishing enzymes with ADP-ribosyl cyclase activity by Graeff, R M, Walseth, T F, Fryxell, K, Branton, W D, Lee, H C

“…Cyclic nucleotides such as cAMP and cGMP are second messengers subserving various signaling pathways. Cyclic ADP-ribose (cADPR), a recently discovered member…”
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Evidence for compartmentalized adenylate kinase catalysis serving a high energy phosphoryl transfer function in rat skeletal muscle by ZELEZNIKAR, R. J, HEYMAN, R. A, GRAEFF, R. M, WALSETH, T. F, DAWIS, S. M, BUTZ, E. A, GOLDBERG, N. D

“…The first characterization of the kinetics and subcellular compartmentation of adenylate kinase activity in intact muscle has been accomplished using rat…”
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Light-induced increases in cGMP metabolic flux correspond with electrical responses of photoreceptors by Ames, A, Walseth, T F, Heyman, R A, Barad, M, Graeff, R M, Goldberg, N D

“…The metabolism of photoreceptor cGMP and the relationship of its light-sensitive regulation to rhodopsin photoisomerization and to the photoreceptor electrical…”
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Regulation of cyclic GMP metabolism in toad photoreceptors. Definition of the metabolic events subserving photoexcited and attenuated states by Dawis, S M, Graeff, R M, Heyman, R A, Walseth, T F, Goldberg, N D

“…Photoreceptor metabolism of cGMP and its regulation were characterized in isolated toad retinas by determining the intensity and time dependence of…”
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ADP-ribosyl Cyclase and CD38 Catalyze the Synthesis of a Calcium-mobilizing Metabolite from NADP+(∗) by Aarhus, Robert, Graeff, Richard M., Dickey, Deborah M., Walseth, Timothy F., Hon, Cheung Lee

“…ADP-ribosyl cyclase catalyzes the cyclization of NAD++ to produce cyclic ADP-ribose (cADPR), which is emerging as an endogenous regulator of the Ca2+2+-induced…”
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Activation and inactivation of Ca2+ release by NAADP by Aarhus, R, Dickey, D M, Graeff, R M, Gee, K R, Walseth, T F, Lee, H C

“…Nicotinic acid adenine dinucleotide phosphate (NAADP+) is a recently identified metabolite of NADP+ that is as potent as inositol trisphosphate (IP3) and…”
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Cyclic GMP-dependent and -independent Effects on the Synthesis of the Calcium Messengers Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate by Graeff, Richard M., Franco, Luisa, De Flora, Antonio, Lee, Hon Cheung

“…Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) have been shown to mobilize intracellular Ca2+ stores by totally…”
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Sensitization of Calcium-induced Calcium Release by Cyclic ADP-ribose and Calmodulin by Lee, H C, Aarhus, R, Graeff, R M

“…Cyclic ADP-ribose (cADPR) is emerging as an endogenous regulator of Ca -induced Ca release (CICR), and we have recently demonstrated that its action is…”
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Nuclear CD38 in retinoic acid-induced HL-60 cells by Yalcintepe, Leman, Albeniz, Isil, Adin-Cinar, Suzan, Tiryaki, Demir, Bermek, Engin, Graeff, Richard M., Lee, Hon Cheung

“…The cell surface antigen, CD38, is a 45-kDa transmembrane protein which is predominantly expressed on hematopoietic cells during differentiation. As a…”
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Fluorescent Analogs of Cyclic ADP-Ribose:  Synthesis, Spectral Characterization, and Use by Graeff, Richard M, Walseth, Timothy F, Hill, Heather K, Lee, Hon Cheung

“…Cyclic ADP-ribose (cADPR) is a Ca2+-mobilizing cyclic nucleotide derived from NAD+. Accumulating evidence indicates that it is an endogenous modulator of the…”
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Subcellular localization of cyclic ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities in porcine airway smooth muscle by White, Thomas A., Johnson, Sonja, Walseth, Timothy F., Lee, Hon Cheung, Graeff, Richard M., Munshi, Cyrus B., Prakash, Y.S., Sieck, Gary C., Kannan, Mathur S.

“…Recent studies have provided evidence for a role of cyclic ADP-ribose (cADPR) in the regulation of intracellular calcium in smooth muscles of the intestine,…”
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A Ca2+-Linked Increase in Coupled cAMP Synthesis and Hydrolysis is an Early Event in Cholinergic and β -adrenergic Stimulation of Parotid Secretion by Deeg, Mark A., Graeff, Richard M., Walseth, Timothy F., Goldberg, Nelson D.

“…The dynamics and compartmental characteristics of cAMP metabolism were examined by 18O labeling of cellular adenine nucleotide α phosphoryls in rat parotid…”
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High throughput fluorescence-based assays for cyclic ADP-ribose, NAADP, and their metabolic enzymes by Graeff, Richard M, Lee, Hon Cheung

“…Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) are two novel Ca(2+) messengers derived respectively from NAD and NADP…”
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Non-identity of cGMP as the guanine nucleotide stimulated to bind to ROS by light and ATP by Yuen, P S, Graeff, R M, Walseth, T F, Goldberg, N D

“…Light, in the presence of ATP, has been reported to stimulate cGMP binding to a 58 kDa protein in ROS (rod outer segments, Fesenko and Krapivinsky, 1986b,…”
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GDP-ribosyl cyclase activity as a measure of CD38 induction by retinoic acid in HL-60 cells by Graeff, R M, Mehta, K, Lee, H C

“…Retinoic acid (RA) treatment of HL-60 cells induces surface expression of CD38. This lymphocytic antigen is also a novel bifunctional enzyme catalyzing the…”
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Radioimmunoassay for measuring endogenous levels of cyclic ADP-ribose in tissues by Graeff, R M, Walseth, T F, Lee, H C

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Bioassay for determining endogenous levels of cyclic ADP-ribose by Walseth, T F, Wong, L, Graeff, R M, Lee, H C

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Magnesium Ions But Not ATP Inhibit Cyclic ADP-Ribose-Induced Calcium Release by Graeff, R.M., Podein, R.J., Aarhus, R., Lee, H.C.

“…The pharmacology of the cyclic ADP-ribose (cADPR)-dependent Ca+2 release mechanism is very similar to that of the ryanodine receptor (RyR). Here we showed that…”
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Large-scale purification of Aplysia ADP-ribosylcyclase and measurement of its activity by fluorimetric assay by Lee, H C, Graeff, R M, Munshi, C B, Walseth, T F, Aarhus, R

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Functional Expression of Soluble Forms of Human CD38 in Escherichia coli and Pichia pastoris by Fryxell, K.B., Odonoghue, K., Graeff, R.M., Lee, H.C., Branton, W.D.

“…Cyclic adenosine diphosphate (ADP)-ribose (cADPR), a metabolite of nicotinamide adenine dinucleotide (NAD +), mobilizes calcium from intracellular stores in…”
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