Search Results - "GRAB, Dennis J."

Benidipine impairs innate immunity converting sublethal to lethal infections in a murine model of spotted fever rickettsiosis by Londoño, Andrés F, Farner, Jennifer M, Dillon, Marlon, Grab, Dennis J, Kim, Yuri, Scorpio, Diana G, Dumler, J Stephen

“…Spotted fever group rickettsiae are tick-borne obligate intracellular bacteria that infect microvascular endothelial cells. Humans and mammalian infection…”
Get full text

Molecular detection of zoonotic tick-borne pathogens from ticks collected from ruminants in four South African provinces by MTSHALI, Khethiwe, KHUMALO, ZTH, NAKAO, Ryo, GRAB, Dennis J., SUGIMOTO, Chihiro, THEKISOE, OMM

“…Ticks carry and transmit a remarkable array of pathogens including bacteria, protozoa and viruses, which may be of veterinary and/or of medical significance…”
Get full text

Early invasion of brain parenchyma by African trypanosomes by Frevert, Ute, Movila, Alexandru, Nikolskaia, Olga V, Raper, Jayne, Mackey, Zachary B, Abdulla, Maha, McKerrow, James, Grab, Dennis J

“…Human African trypanosomiasis or sleeping sickness is a vector-borne parasitic disease that has a major impact on human health and welfare in sub-Saharan…”
Get full text

Trypanosoma brucei rhodesiense Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response by Costa, Tatiana F R, Goundry, Amy, Morrot, Alexandre, Grab, Dennis J, Mottram, Jeremy C, Lima, Ana Paula C A

“…The protozoan causes Human African Trypanosomiasis, also known as sleeping sickness, and penetrates the central nervous system, leading to meningoencephalitis…”
Get full text

Anaplasma phagocytophilum Ankyrin A Protein (AnkA) Enters the Nucleus Using an Importin-β-, RanGTP-Dependent Mechanism by Kim, Yuri, Wang, Jianyang, Clemens, Emily G, Grab, Dennis J, Dumler, J Stephen

“…, a tick-borne obligately intracellular bacterium of neutrophils, causes human granulocytic anaplasmosis. Ankyrin A (AnkA), an effector protein with multiple…”
Get full text

Human granulocytic anaplasmosis and Anaplasma phagocytophilum by Dumler, J Stephen, Choi, Kyoung-Seong, Garcia-Garcia, Jose Carlos, Barat, Nicole S, Scorpio, Diana G, Garyu, Justin W, Grab, Dennis J, Bakken, Johan S

“…Human granulocytic anaplasmosis is a tickborne rickettsial infection of neutrophils caused by Anaplasma phagocytophilum. The human disease was first identified…”
Get full text

Loop-Mediated Isothermal Amplification for Detection of African Trypanosomes by KUBOKI, Noritaka, INOUE, Noboru, SAKURAI, Tatsuya, DI CELLO, Francescopaolo, GRAB, Dennis J, SUZUKI, Hiroshi, SUGIMOTO, Chihiro, IGARASHI, Ikuo

“…Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Using detergent-enhanced LAMP for African trypanosome detection in human cerebrospinal fluid and implications for disease staging by Grab, Dennis J, Nikolskaia, Olga V, Courtioux, Bertrand, Thekisoe, Oriel M M, Magez, Stefan, Bogorad, Maxim, Dumler, J Stephen, Bisser, Sylvie

“…Where human African trypanosomiasis (HAT) patients are seen, failure to microscopically diagnose infections by Trypanosoma brucei gambiense in blood smears…”
Get full text

Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host by Levy, David Jessula, Goundry, Amy, Laires, Raquel S S, Costa, Tatiana F R, Novo, Carlos Mendes, Grab, Dennis J, Mottram, Jeremy C, Lima, Ana Paula C A

“…Trypanosoma brucei rhodesiense is one of the causative agents of Human African Trypanosomiasis (HAT), known as sleeping sickness. The parasite invades the…”
Get full text

RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model by Abdulla, Maha-Hamadien, O'Brien, Theresa, Mackey, Zachary B, Sajid, Mohamed, Grab, Dennis J, McKerrow, James H

“…We investigated the roles played by the cysteine proteases cathepsin B and cathepsin L (brucipain) in the pathogenesis of Trypansoma brucei brucei in both an…”
Get full text

Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells by Grab, Dennis J, Garcia-Garcia, Jose C, Nikolskaia, Olga V, Kim, Yuri V, Brown, Amanda, Pardo, Carlos A, Zhang, Yongqing, Becker, Kevin G, Wilson, Brenda A, de A Lima, Ana Paula C, Scharfstein, Julio, Dumler, J Stephen

“…Using human brain microvascular endothelial cells (HBMECs) as an in vitro model for how African trypanosomes cross the human blood-brain barrier (BBB) we…”
Get full text

Traversal of human and animal trypanosomes across the blood-brain barrier by Grab, Dennis J, Kennedy, Peter GE

“…The neurological complications of human African trypanosomiasis (HAT) in man caused by the unicellular protozoan parasites Trypanosoma brucei gambiense and T…”
Get full text

Using detergent to enhance detection sensitivity of African trypanosomes in human CSF and blood by loop-mediated isothermal amplification (LAMP) by Grab, Dennis J, Nikolskaia, Olga V, Inoue, Noboru, Thekisoe, Oriel M M, Morrison, Liam J, Gibson, Wendy, Dumler, J Stephen

“…The loop-mediated isothermal amplification (LAMP) assay, with its advantages of simplicity, rapidity and cost effectiveness, has evolved as one of the most…”
Get full text

Anaplasma phagocytophilum-Borrelia burgdorferi Coinfection Enhances Chemokine, Cytokine, and Matrix Metalloprotease Expression by Human Brain Microvascular Endothelial Cells by Grab, Dennis J, Nyarko, Elvis, Barat, Nicole C, Nikolskaia, Olga V, Dumler, J Stephen

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Borrelia burgdorferi, Host-Derived Proteases, and the Blood-Brain Barrier by Grab, Dennis J, Perides, George, Dumler, J. Stephen, Kim, Kee Jun, Park, Jinho, Kim, Yuri V, Nikolskaia, Olga, Choi, Kyoung Seong, Stins, Monique F, Kim, Kwang Sik

“…Neurological manifestations of Lyme disease in humans are attributed in part to penetration of the blood-brain barrier (BBB) and invasion of the central…”
Get full text

Placental growth factor negatively regulates retinal endothelial cell barrier function through suppression of glucose‐6‐phosphate dehydrogenase and antioxidant defense systems by Huang, Hu, Lennikov, Anton, Saddala, Madhu Sudhana, Gozal, David, Grab, Dennis J., Khalyfa, Abdelnaby, Fan, Lijuan

“…We report that placental growth factor (PlGF) negatively affects the endothelial cell (EC) barrier function through a novel regulatory mechanism. The PlGF mAb…”
Get full text

Characteristics of novel insect defensin-based membrane-disrupting trypanocidal peptides by Yamage, M.(National Inst. of Agrobiological Sciences, Tsukuba, Ibaraki (Japan)), Yoshiyama, M, Grab, D.J, Kubo, M, Iwasaki, T, Kitani, H, Ishibashi, J, Yamakawa, M

“…Synthetic D- and L-amino acid type cationic 9-mer peptides (all sequences were synthesized as D- or L-amino acids) derived from the active sites of insect…”
Get full text

Spotted fever rickettsia-induced microvascular endothelial barrier dysfunction is delayed by the calcium channel blocker benidipine by Kim, Yuri, Clemens, Emily G., Farner, Jennifer M., Londono-Barbaran, Andres, Grab, Dennis J., Dumler, J. Stephen

“…The tick-borne bacterium Rickettsia parkeri is an obligate intracellular pathogen that belongs to spotted fever group rickettsia (SFGR). The SFG pathogens are…”
Get full text

Membrane active chelators as novel anti-African trypanosome and anti-malarial drugs by Grab, Dennis J, Nenortas, Elizabeth, Bakshi, Rahul P, Nikolskaia, Olga V, Friedman, Jonathan E, Shapiro, Theresa A

“…Abstract Malaria ( Plasmodium spp.) and human African trypanosomiasis ( Trypanosoma brucei spp.) are vector borne, deadly parasitic diseases. While…”
Get full text

Proteomics reveals ablation of PlGF increases antioxidant and neuroprotective proteins in the diabetic mouse retina by Saddala, Madhu Sudhana, Lennikov, Anton, Grab, Dennis J., Liu, Guei-Sheung, Tang, Shibo, Huang, Hu

“…Placental growth factor (PlGF or PGF), a member of the vascular endothelial growth factor (VEGF) sub-family, plays a crucial role in pathological angiogenesis…”
Get full text