Search Results - "GRÜNIG, Ekkehard"

Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study by Coghlan, J Gerry, Denton, Christopher P, Grünig, Ekkehard, Bonderman, Diana, Distler, Oliver, Khanna, Dinesh, Müller-Ladner, Ulf, Pope, Janet E, Vonk, Madelon C, Doelberg, Martin, Chadha-Boreham, Harbajan, Heinzl, Harald, Rosenberg, Daniel M, McLaughlin, Vallerie V, Seibold, James R

“…Earlier detection of pulmonary arterial hypertension (PAH), a leading cause of death in systemic sclerosis (SSc), facilitates earlier treatment. The objective…”
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Pulmonary Vascular Hemodynamic Response to Exercise in Cardiopulmonary Diseases by Lewis, Gregory D., Bossone, Eduardo, Naeije, Robert, Grünig, Ekkehard, Saggar, Rajeev, Lancellotti, Patrizio, Ghio, Stefano, Varga, Janos, Rajagopalan, Sanjay, Oudiz, Ronald, Rubenfire, Melvyn

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Riociguat for the Treatment of Pulmonary Arterial Hypertension by Ghofrani, Hossein-Ardeschir, Galiè, Nazzareno, Grimminger, Friedrich, Grünig, Ekkehard, Humbert, Marc, Jing, Zhi-Cheng, Keogh, Anne M, Langleben, David, Kilama, Michael Ochan, Fritsch, Arno, Neuser, Dieter, Rubin, Lewis J

“…In this trial, 443 patients with pulmonary arterial hypertension were assigned to placebo or to the soluble guanylate cyclase stimulator riociguat. At 12…”
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Risk stratification and medical therapy of pulmonary arterial hypertension by Galiè, Nazzareno, Channick, Richard N, Frantz, Robert P, Grünig, Ekkehard, Jing, Zhi Cheng, Moiseeva, Olga, Preston, Ioana R, Pulido, Tomas, Safdar, Zeenat, Tamura, Yuichi, McLaughlin, Vallerie V

“…Pulmonary arterial hypertension (PAH) remains a severe clinical condition despite the availability over the past 15 years of multiple drugs interfering with…”
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Incidence of pulmonary hypertension and determining factors in patients with systemic sclerosis by Coghlan, J Gerry, Wolf, Matthias, Distler, Oliver, Denton, Christopher P, Doelberg, Martin, Harutyunova, Satenik, Marra, Alberto M, Benjamin, Nicola, Fischer, Christine, Grünig, Ekkehard

“…The objective of this study was to evaluate the incidence of pulmonary hypertension (PH) and determining factors in patients with systemic sclerosis (SSc) and…”
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ERS Statement on Chronic Thromboembolic Pulmonary Hypertension by Delcroix, Marion, Torbicki, Adam, Gopalan, Deepa, Sitbon, Olivier, Klok, Frederikus A, Lang, Irene, Jenkins, David, Kim, Nick H, Humbert, Marc, Jais, Xavier, Noordegraaf, Anton Vonk, Pepke-Zaba, Joanna, Brénot, Philippe, Dorfmuller, Peter, Fadel, Elie, Ghofrani, Hossein-Ardeschir, Hoeper, Marius M, Jansa, Pavel, Madani, Michael, Matsubara, Hiromi, Ogo, Takeshi, Grünig, Ekkehard, D'Armini, Andrea, Galie, Nazzareno, Meyer, Bernhard, Corkery, Patrick, Meszaros, Gergely, Mayer, Eckhard, Simonneau, Gérald

“…Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of acute pulmonary embolism, either symptomatic or not. The occlusion of proximal…”
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Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension by Hoeper, Marius M., Badesch, David B., Ghofrani, H. Ardeschir, Gibbs, J. Simon R., Gomberg-Maitland, Mardi, McLaughlin, Vallerie V., Preston, Ioana R., Souza, Rogerio, Waxman, Aaron B., Grünig, Ekkehard, Kopeć, Grzegorz, Meyer, Gisela, Olsson, Karen M., Rosenkranz, Stephan, Xu, Yayun, Miller, Barry, Fowler, Marcie, Butler, John, Koglin, Joerg, de Oliveira Pena, Janethe, Humbert, Marc

“…In this double-blind, randomized, placebo-controlled trial, sotatercept increased the exercise capacity of patients with pulmonary arterial hypertension…”
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Genetics and Genomics of Pulmonary Arterial Hypertension by Soubrier, Florent, MD, PhD, Chung, Wendy K., MD, PhD, Machado, Rajiv, PhD, Grünig, Ekkehard, MD, Aldred, Micheala, PhD, Geraci, Mark, MD, Loyd, James E., MD, Elliott, C. Gregory, MD, Trembath, Richard C., MD, Newman, John H., MD, Humbert, Marc, MD, PhD

“…Major discoveries have been obtained within the last decade in the field of hereditary predisposition to pulmonary arterial hypertension (PAH). Among them, the…”
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COMPERA 2.0: a refined four-stratum risk assessment model for pulmonary arterial hypertension by Hoeper, Marius M., Pausch, Christine, Olsson, Karen M., Huscher, Doerte, Pittrow, David, Grünig, Ekkehard, Staehler, Gerd, Vizza, Carmine Dario, Gall, Henning, Distler, Oliver, Opitz, Christian, Gibbs, J. Simon R., Delcroix, Marion, Ghofrani, H. Ardeschir, Park, Da-Hee, Ewert, Ralf, Kaemmerer, Harald, Kabitz, Hans-Joachim, Skowasch, Dirk, Behr, Juergen, Milger, Katrin, Halank, Michael, Wilkens, Heinrike, Seyfarth, Hans-Jürgen, Held, Matthias, Dumitrescu, Daniel, Tsangaris, Iraklis, Vonk-Noordegraaf, Anton, Ulrich, Silvia, Klose, Hans, Claussen, Martin, Lange, Tobias J., Rosenkranz, Stephan

“…Background Risk stratification plays an essential role in the management of patients with pulmonary arterial hypertension (PAH). The current European…”
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Three- Versus Two-Drug Therapy for Patients With Newly Diagnosed Pulmonary Arterial Hypertension by Chin, Kelly M, Sitbon, Olivier, Doelberg, Martin, Feldman, Jeremy, Gibbs, J Simon R, Grünig, Ekkehard, Hoeper, Marius M, Martin, Nicolas, Mathai, Stephen C, McLaughlin, Vallerie V, Perchenet, Loïc, Poch, David, Saggar, Rajan, Simonneau, Gérald, Galiè, Nazzareno

“…In pulmonary arterial hypertension (PAH), there are no data comparing initial triple oral therapy with initial double oral therapy. TRITON (The Efficacy and…”
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Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension by Sindi, Hebah A., Russomanno, Giusy, Satta, Sandro, Abdul-Salam, Vahitha B., Jo, Kyeong Beom, Qazi-Chaudhry, Basma, Ainscough, Alexander J., Szulcek, Robert, Jan Bogaard, Harm, Morgan, Claire C., Pullamsetti, Soni S., Alzaydi, Mai M., Rhodes, Christopher J., Piva, Roberto, Eichstaedt, Christina A., Grünig, Ekkehard, Wilkins, Martin R., Wojciak-Stothard, Beata

“…Pulmonary arterial hypertension (PAH) is a severe disorder of lung vasculature that causes right heart failure. Homoeostatic effects of flow-activated…”
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Cardiopulmonary exercise testing for detecting pulmonary arterial hypertension in systemic sclerosis by Dumitrescu, Daniel, Nagel, Christian, Kovacs, Gabor, Bollmann, Tom, Halank, Michael, Winkler, Jörg, Hellmich, Martin, Grünig, Ekkehard, Olschewski, Horst, Ewert, Ralf, Rosenkranz, Stephan

“…Pulmonary arterial hypertension (PAH) is a devastating disease with limited survival and occurs as a frequent complication in patients with systemic sclerosis…”
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Pulmonary Hypertension in Patients With COPD: Results From the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA) by Vizza, Carmine Dario, Hoeper, Marius M, Huscher, Doerte, Pittrow, David, Benjamin, Nicola, Olsson, Karen M, Ghofrani, H Ardeschir, Held, Matthias, Klose, Hans, Lange, Tobias, Rosenkranz, Stephan, Dumitrescu, Daniel, Badagliacca, Roberto, Claussen, Martin, Halank, Michael, Vonk-Noordegraaf, Anton, Skowasch, Dirk, Ewert, Ralf, Gibbs, J Simon R, Delcroix, Marion, Skride, Andris, Coghlan, Gerry, Ulrich, Silvia, Opitz, Christian, Kaemmerer, Harald, Distler, Oliver, Grünig, Ekkehard

“…Pulmonary hypertension (PH) in COPD is a poorly investigated clinical condition. Which factors determine the outcome of PH in COPD? We analyzed the…”
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Haemodynamic phenotypes and survival in patients with systemic sclerosis: the impact of the new definition of pulmonary arterial hypertension by Xanthouli, Panagiota, Jordan, Suzana, Milde, Nicklas, Marra, Alberto, Blank, Norbert, Egenlauf, Benjamin, Gorenflo, Matthias, Harutyunova, Satenik, Lorenz, Hanns-Martin, Nagel, Christian, Theobald, Vivienne, Lichtblau, Mona, Berlier, Charlotte, Ulrich, Silvia, Grünig, Ekkehard, Benjamin, Nicola, Distler, Oliver

“…In this study, we investigated the impact of the new haemodynamic definition of pulmonary arterial hypertension (PAH) as proposed by the 6th PH World Symposium…”
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Riociguat in pulmonary hypertension and heart failure with preserved ejection fraction: the haemoDYNAMIC trial by Dachs, Theresa Marie, Duca, Franz, Rettl, René, Binder-Rodriguez, Christina, Dalos, Daniel, Ligios, Luciana Camuz, Kammerlander, Andreas, Grünig, Ekkehard, Pretsch, Ingrid, Steringer-Mascherbauer, Regina, Ablasser, Klemens, Wargenau, Manfred, Mascherbauer, Julia, Lang, Irene M, Hengstenberg, Christian, Badr-Eslam, Roza, Kastner, Johannes, Bonderman, Diana

“…Abstract Aims The presence of pulmonary hypertension (PH) severely aggravates the clinical course of heart failure with preserved ejection fraction (HFpEF). To…”
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Exercise and respiratory training improve exercise capacity and quality of life in patients with severe chronic pulmonary hypertension by MERELES, Derliz, EHLKEN, Nicola, HOLZAPFEL, Nicole, OPITZ, Christian, WINKLER, Jörg, HERTH, Felix F. J, WILKENS, Heinrike, KATUS, Hugo A, OLSCHEWSKI, Horst, GRÜNIG, Ekkehard, KREUSCHER, Sandra, GHOFRANI, Stefanie, HOEPER, Marius M, HALANK, Michael, MEYER, F. Joachim, KARGER, Gabriele, BUSS, Jan, JUENGER, Jana

“…Pulmonary hypertension (PH) is associated with restricted physical capacity, limited quality of life, and a poor prognosis because of right heart failure. The…”
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Riociguat for the treatment of pulmonary arterial hypertension: a long-term extension study (PATENT-2) by Rubin, Lewis J, Galiè, Nazzareno, Grimminger, Friedrich, Grünig, Ekkehard, Humbert, Marc, Jing, Zhi-Cheng, Keogh, Anne, Langleben, David, Fritsch, Arno, Menezes, Flavia, Davie, Neil, Ghofrani, Hossein-Ardeschir

“…Riociguat is a soluble, guanylate cyclase stimulator, approved for pulmonary arterial hypertension. In the 12-week PATENT-1 study, riociguat was well tolerated…”
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RESPITE: switching to riociguat in pulmonary arterial hypertension patients with inadequate response to phosphodiesterase-5 inhibitors by Hoeper, Marius M, Simonneau, Gérald, Corris, Paul A, Ghofrani, Hossein-Ardeschir, Klinger, James R, Langleben, David, Naeije, Robert, Jansa, Pavel, Rosenkranz, Stephan, Scelsi, Laura, Grünig, Ekkehard, Vizza, Carmine Dario, Chang, MiKyung, Colorado, Pablo, Meier, Christian, Busse, Dennis, Benza, Raymond L

“…A proportion of pulmonary arterial hypertension (PAH) patients do not reach treatment goals with phosphodiesterase-5 inhibitors (PDE5i). RESPITE investigated…”
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Stressing the Cardiopulmonary Vascular System: The Role of Echocardiography by Rudski, Lawrence G., Gargani, Luna, Armstrong, William F., Lancellotti, Patrizio, Lester, Steven J., Grünig, Ekkehard, D'Alto, Michele, Åström Aneq, Meriam, Ferrara, Francesco, Saggar, Rajeev, Saggar, Rajan, Naeije, Robert, Picano, Eugenio, Schiller, Nelson B., Bossone, Eduardo

“…The cardiopulmonary vascular system represents a key determinant of prognosis in several cardiorespiratory diseases. Although right heart catheterization is…”
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Imaging the heart in pulmonary hypertension: an update by Grünig, Ekkehard, Peacock, Andrew J

“…Noninvasive imaging of the heart plays an important role in the diagnosis and management of pulmonary hypertension (PH), and several well-established…”
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