Search Results - "GRÜN, Felix"

Minireview: The Case for Obesogens by Grün, Felix, Blumberg, Bruce

“…Obesity and obesity-related disorders, such as type 2 diabetes, hypertension, and cardiovascular disease, are epidemic in Western countries, particularly the…”
Get full text

Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis by Grün, Felix, Blumberg, Bruce

“…The modern world is plagued with expanding epidemics of diseases related to metabolic dysfunction. The factors that are driving obesity, diabetes,…”
Get full text

"You Never Get a Second Chance": First Impressions of Physicians Depend on Their Body Posture and Gender by Grün, Felix C, Heibges, Maren, Westfal, Viola, Feufel, Markus A

“…A first impression matters, in particular when encounters are brief as in most doctor-patient interactions. In this study, we investigate how physicians' body…”
Get full text

Vitamin K2 Regulation of Bone Homeostasis Is Mediated by the Steroid and Xenobiotic Receptor SXR by Tabb, Michelle M., Sun, Aixu, Zhou, Changcheng, Grün, Felix, Errandi, Jody, Romero, Kimberly, Pham, Hang, Inoue, Satoshi, Mallick, Shyamali, Lin, Min, Forman, Barry M., Blumberg, Bruce

“…Vitamin K2 is a critical nutrient required for blood clotting that also plays an important role in bone formation. Vitamin K2 supplementation up-regulates the…”
Get full text

Environmental Obesogens: Organotins and Endocrine Disruption via Nuclear Receptor Signaling by Grün, Felix, Blumberg, Bruce

“…Over the last two decades, the incidence of obesity and associated metabolic syndrome diseases has risen dramatically, becoming a global health crisis…”
Get full text

TOCOTRIENOLS ACTIVATE THE STEROID AND XENOBIOTIC RECEPTOR, SXR, AND SELECTIVELY REGULATE EXPRESSION OF ITS TARGET GENES by CHANGCHENG ZHOU, TABB, Michelle M, SADATRAFIEI, Asal, GRÜN, Felix, BLUMBERG, Bruce

“…Vitamin E is an essential nutrient with antioxidant activity. Vitamin E is comprised of eight members, α-, β-, γ-, and δ-tocopherols and α-, β-, γ-, and…”
Get full text

Endocrine-Disrupting Organotin Compounds Are Potent Inducers of Adipogenesis in Vertebrates by Grün, Felix, Watanabe, Hajime, Zamanian, Zamaneh, Maeda, Lauren, Arima, Kayo, Cubacha, Ryan, Gardiner, David M, Kanno, Jun, Iguchi, Taisen, Blumberg, Bruce

“…Dietary and xenobiotic compounds can disrupt endocrine signaling, particularly of steroid receptors and sexual differentiation. Evidence is also mounting that…”
Get full text

Retinoic acid signaling in the brain marks formation of optic projections, maturation of the dorsal telencephalon, and function of limbic sites by Luo, Tuanlian, Wagner, Elisabeth, Grün, Felix, Dräger, Ursula C.

“…As retinoic acid (RA) is known to regulate the expression of many neuronal proteins, it is likely to influence overall development and function of the brain;…”
Get full text

Endocrine disrupters as obesogens by Grün, Felix, Blumberg, Bruce

“…The recent dramatic rise in obesity rates is an alarming global health trend that consumes an ever increasing portion of health care budgets in Western…”
Get full text

Deformed frogs and environmental retinoids by Gardiner, David, Ndayibagira, A., Grün, Felix, Blumberg, Bruce

“…Since the early 1990s, a substantial number of deformed frogs have been observed in North America, particularly in the upper Midwest and Canada. Attempts to…”
Get full text

The Obesogen Tributyltin by Grün, Felix

“…The obesogen hypothesis postulates the role of environmental chemical pollutants that disrupt homeostatic controls and adaptive mechanisms to promote…”
Get full text

Obesogens by Grün, Felix

“…The environmental obesogen hypothesis postulates chemical pollutants that are able to promote obesity by altering homeostatic metabolic set-points, disrupting…”
Get full text

Mutual repression between steroid and xenobiotic receptor and NF-κB signaling pathways links xenobiotic metabolism and inflammation by Zhou, Changcheng, Tabb, Michelle M, Nelson, Edward L, Grun, Felix, Verma, Suman, Sadatrafiei, Asal, Lin, Min, Mallick, Shyamali, Forman, Barry M, Thummel, Kenneth E, Blumberg, Bruce

“…While it has long been known that inflammation and infection reduce expression of hepatic cytochrome P450 (CYP) genes involved in xenobiotic metabolism and…”
Get full text

Spatially resolved detection of small molecules from press-dried plant tissue using MALDI imaging by Long, Zane G, Le, Jonathan V, Katz, Benjamin B, Lopez, Belen G, Tenenbaum, Emily D, Semmling, Bonnie, Schmidt, Ryan J, Grün, Felix, Butts, Carter T, Martin, Rachel W

“…Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a chemical imaging method that can visualize spatial distributions of…”
Get full text

The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor by Zhou, Changcheng, Poulton, Emma-Jane, Grün, Felix, Bammler, Theo K, Blumberg, Bruce, Thummel, Kenneth E, Eaton, David L

“…Sulforaphane (SFN) is a biologically active phytochemical found abundantly in broccoli. SFN has been promoted as a putative chemopreventive agent to reduce…”
Get more information

Highly Chlorinated PCBs Inhibit the Human Xenobiotic Response Mediated by the Steroid and Xenobiotic Receptor (SXR) by Tabb, Michelle M., Kholodovych, Vladyslav, Grün, Felix, Zhou, Changcheng, Welsh, William J., Blumberg, Bruce

“…Polychlorinated biphenyls (PCBs) are a family of persistent organic contaminants suspected to cause adverse effects in wildlife and humans. In rodents, PCBs…”
Get full text

Activation of steroid and xenobiotic receptor (SXR, NR1I2) and its orthologs in laboratory, toxicologic, and genome model species by Milnes, Matthew R, Garcia, Adriana, Grossman, Emily, Grün, Felix, Shiotsugu, Jason, Tabb, Michelle M, Kawashima, Yukio, Katsu, Yoshinao, Watanabe, Hajime, Iguchi, Taisen, Blumberg, Bruce

“…Nuclear receptor subfamily 1, group I, member 2 (NR1I2), commonly known as steroid and xenobiotic receptor (SXR) in humans, is a key ligand-dependent…”
Get full text

Purification, Cloning, and Bacterial Expression of Retinol Dehydratase from by Grün, Felix, Noy, Noa, Hämmerling, Ulrich, Buck, Jochen

Get full text

Towards Scenario- and Capability-Driven Dataset Development and Evaluation: An Approach in the Context of Mapless Automated Driving by Grün, Felix, Nolte, Marcus, Maurer, Markus

“…The foundational role of datasets in defining the capabilities of deep learning models has led to their rapid proliferation. At the same time, published…”
Get full text

The Obesogen Tributyltin by Grün, Felix

Get full text