Search Results - "GRØNBAEK, Kirsten"

Pre-treatment health-related quality of life parameters have prognostic impact in patients > 65 years with newly diagnosed mantle cell lymphoma: The Nordic Lymphoma Group MCL4 (LENA-BERIT) experience by Lindberg, Åsa, Eskelund, Christian Winther, Albertsson-Lindblad, Alexandra, Kolstad, Arne, Laurell, Anna, Räty, Riikka, Grønbaek, Kirsten, Geisler, Christian Hartmann, Jerkeman, Mats

“…Mantle cell lymphoma (MCL) is a rare, often aggressive type of B-cell lymphoma with poor survival and no cure. Cancer and cancer treatment has a negative…”
Get full text

Randomized phase II study of azacitidine ± lenalidomide in higher-risk myelodysplastic syndromes and acute myeloid leukemia with a karyotype including Del(5q) by Rasmussen, Bengt, Göhring, Gudrun, Bernard, Elsa, Nilsson, Lars, Tobiasson, Magnus, Jädersten, Martin, Garelius, Hege, Dybedal, Ingunn, Grønbaek, Kirsten, Ejerblad, Elisabeth, Lorenz, Fryderyk, Flogegård, Max, Marcher, Claus Werenberg, Öster Fernström, Annette, Cavelier, Lucia, Papaemmanuil, Elli, Ebeling, Freja, Kittang, Astrid Olsnes, Nørgaard, Jan Maxwell, Saft, Leonie, Möllgård, Lars, Hellström-Lindberg, Eva

Get full text

Acute and persistent symptoms in non-hospitalized PCR-confirmed COVID-19 patients by Bliddal, Sofie, Banasik, Karina, Pedersen, Ole Birger, Nissen, Janna, Cantwell, Lisa, Schwinn, Michael, Tulstrup, Morten, Westergaard, David, Ullum, Henrik, Brunak, Søren, Tommerup, Niels, Feenstra, Bjarke, Geller, Frank, Ostrowski, Sisse Rye, Grønbæk, Kirsten, Nielsen, Claus Henrik, Nielsen, Susanne Dam, Feldt-Rasmussen, Ulla

“…Reports of persistent symptoms after hospitalization with COVID-19 have raised concern of a “long COVID” syndrome. This study aimed at determining the…”
Get full text

Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine by Liu, Minmin, Ohtani, Hitoshi, Zhou, Wanding, Ørskov, Andreas Due, Charlet, Jessica, Zhang, Yang W., Shen, Hui, Baylin, Stephen B., Liang, Gangning, Grønbæk, Kirsten, Jones, Peter A.

“…Vitamin C deficiency is found in patients with cancer and might complicate various therapy paradigms. Here we show how this deficiency may influence the use of…”
Get full text

The role of vitamin C in epigenetic cancer therapy by Mikkelsen, Stine Ulrik, Gillberg, Linn, Lykkesfeldt, Jens, Grønbæk, Kirsten

“…The role of vitamin C in the treatment of cancer has been subject to controversy for decades. Within the past 10 years, mechanistic insight into the importance…”
Get full text

TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis by Tulstrup, Morten, Soerensen, Mette, Hansen, Jakob Werner, Gillberg, Linn, Needhamsen, Maria, Kaastrup, Katja, Helin, Kristian, Christensen, Kaare, Weischenfeldt, Joachim, Grønbæk, Kirsten

“…Mutations in the epigenetic modifier TET2 are frequent in myeloid malignancies and clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia…”
Get full text

Epigenetic therapy in hematological cancers by Dimopoulos, Konstantinos, Grønbæk, Kirsten

“…The increasing depth of knowledge about cancer biology throughout the last decades, has underlined the importance of not only genetic aberrations, but also…”
Get full text

Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers by Saini, Sunil Kumar, Ørskov, Andreas Due, Bjerregaard, Anne-Mette, Unnikrishnan, Ashwin, Holmberg-Thydén, Staffan, Borch, Annie, Jensen, Kathrine Valentini, Anande, Govardhan, Bentzen, Amalie Kai, Marquard, Andrea Marion, Tamhane, Tripti, Treppendahl, Marianne Bach, Gang, Anne Ortved, Dufva, Inge Høgh, Szallasi, Zoltan, Ternette, Nicola, Pedersen, Anders Gorm, Eklund, Aron Charles, Pimanda, John, Grønbæk, Kirsten, Hadrup, Sine Reker

“…Human endogenous retroviruses (HERV) form a substantial part of the human genome, but mostly remain transcriptionally silent under strict epigenetic…”
Get full text

miR-449 inhibits cell proliferation and is down-regulated in gastric cancer by Bou Kheir, Tony, Futoma-Kazmierczak, Ewa, Jacobsen, Anders, Krogh, Anders, Bardram, Linda, Hother, Christoffer, Grønbæk, Kirsten, Federspiel, Birgitte, Lund, Anders H, Friis-Hansen, Lennart

“…Gastric cancer is the fourth most common cancer in the world and the second most prevalent cause of cancer related death. The development of gastric cancer is…”
Get full text

Epigenetic changes in cancer by GRØNBÆK, KIRSTEN, HOTHER, CHRISTOFFER, JONES, PETER A.

“…A cancer develops when a cell acquires specific growth advantages through the stepwise accumulation of heritable changes in gene function. Basically, this…”
Get full text

Long Non-Coding RNAs Guide the Fine-Tuning of Gene Regulation in B-Cell Development and Malignancy by Dahl, Mette, Kristensen, Lasse Sommer, Grønbæk, Kirsten

“…With the introduction of next generation sequencing methods, such as RNA sequencing, it has become apparent that alterations in the non-coding regions of our…”
Get full text

Enzyme-free digital counting of endogenous circular RNA molecules in B-cell malignancies by Dahl, Mette, Daugaard, Iben, Andersen, Maria Schertz, Hansen, Thomas Birkballe, Grønbæk, Kirsten, Kjems, Jørgen, Kristensen, Lasse Sommer

“…Circular RNAs (circRNAs) are covalently closed endogenous molecules with tissue- and disease-specific expression patterns, which have potential as diagnostic…”
Get full text

A user's guide to multicolor flow cytometry panels for comprehensive immune profiling by Holmberg-Thyden, Staffan, Grønbæk, Kirsten, Gang, Anne Ortved, El Fassi, Daniel, Hadrup, Sine Reker

“…Multicolor flow cytometry is an essential tool for studying the immune system in health and disease, allowing users to extract longitudinal multiparametric…”
Get full text

Vitamin C – A new player in regulation of the cancer epigenome by Gillberg, Linn, Ørskov, Andreas D., Liu, Minmin, Harsløf, Laurine B.S., Jones, Peter A., Grønbæk, Kirsten

“…Over the past few years it has become clear that vitamin C, as a provider of reduced iron, is an essential factor for the function of epigenetic regulators…”
Get full text

KMT2D mutations and TP53 disruptions are poor prognostic biomarkers in mantle cell lymphoma receiving high-dose therapy: a FIL study by Ferrero, Simone, Rossi, Davide, Rinaldi, Andrea, Bruscaggin, Alessio, Spina, Valeria, Eskelund, Christian W, Evangelista, Andrea, Moia, Riccardo, Kwee, Ivo, Dahl, Christina, Di Rocco, Alice, Stefoni, Vittorio, Diop, Fary, Favini, Chiara, Ghione, Paola, Mahmoud, Abdurraouf Mokhtar, Schipani, Mattia, Kolstad, Arne, Barbero, Daniela, Novero, Domenico, Paulli, Marco, Zamò, Alberto, Jerkeman, Mats, da Silva, Maria Gomes, Santoro, Armando, Molinari, Annalia, Ferreri, Andres, Grønbæk, Kirsten, Piccin, Andrea, Cortelazzo, Sergio, Bertoni, Francesco, Ladetto, Marco, Gaidano, Gianluca

“…In recent years, the outcome of mantle cell lymphoma (MCL) has improved, especially in younger patients, receiving cytarabine-containing chemoimmunotherapy and…”
Get full text

Twin DNA Methylation Profiling Reveals Flare‐Dependent Interferon Signature and B Cell Promoter Hypermethylation in Systemic Lupus Erythematosus by Ulff‐Møller, Constance J., Asmar, Fazila, Liu, Yi, Svendsen, Anders J., Busato, Florence, Grønbæk, Kirsten, Tost, Jörg, Jacobsen, Søren

“…Objective Systemic lupus erythematosus (SLE) has limited monozygotic twin concordance, implying a role for pathogenic factors other than genetic variation,…”
Get full text

TP53 mutations identify younger mantle cell lymphoma patients who do not benefit from intensive chemoimmunotherapy by Eskelund, Christian W., Dahl, Christina, Hansen, Jakob W., Westman, Maj, Kolstad, Arne, Pedersen, Lone B., Montano-Almendras, Carmen P., Husby, Simon, Freiburghaus, Catja, Ek, Sara, Pedersen, Anja, Niemann, Carsten, Räty, Riikka, Brown, Peter, Geisler, Christian H., Andersen, Mette K., Guldberg, Per, Jerkeman, Mats, Grønbæk, Kirsten

“…Despite recent advances in lymphoma treatment, mantle cell lymphoma (MCL) remains incurable, and we are still unable to identify patients who will not benefit…”
Get full text

Low mortality from COVID-19 infection in patients with B-cell lymphoma after bispecific CD20xCD3 therapy by Kyvsgaard, Emil R, Riley, Caroline, Clausen, Michael Roost, Harsløf, Mads, Heftdal, Line Dam, Niemann, Carsten U, Grønbaek, Kirsten, Hutchings, Martin, Husby, Simon

Get full text

Increased myeloid‐derived suppressor cell activation in clonal cytopenia of undetermined significance and low‐risk myelodysplastic syndrome by Bentivegna, Sofia, Côme, Christophe, Porse, Bo, Andersen, Mads Hald, Grønbæk, Kirsten

Get full text

Clonal hematopoiesis in elderly twins: concordance, discordance, and mortality by Hansen, Jakob Werner, Pedersen, Dorthe Almind, Larsen, Lisbeth Aagaard, Husby, Simon, Clemmensen, Signe Bedsted, Hjelmborg, Jacob, Favero, Francesco, Weischenfeldt, Joachim, Christensen, Kaare, Grønbæk, Kirsten

“…Clonal hematopoiesis (CH) of indeterminate potential (CHIP) is defined by mutations in myeloid cancer–associated genes with a variant allele frequency of at…”
Get full text